Genetic Variation and Population Structure in Native Americans
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data avail...
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ftunivgeneve:oai:unige.ch:unige:18198 2023-05-15T15:44:14+02:00 Genetic Variation and Population Structure in Native Americans Wang, Sijia Lewis, Cecil M. Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya, Gabriel Rojas, Winston Parra, Maria V. Molina, Julio A. Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana M. Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco M. Petzl-Erler, Maria Luiza Tsuneto, Luiza T. Llop, Elena Rothhammer, Francisco Excoffier, Laurent Georges Louis Feldman, Marcus W. Rosenberg, Noah A. Ruiz-Linares, Andrés 2007 https://archive-ouverte.unige.ch/unige:18198 eng eng info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.0030185 unige:18198 https://archive-ouverte.unige.ch/unige:18198 info:eu-repo/semantics/openAccess ISSN: 1553-7390 PLOS genetics, Vol. 3, No 11 (2007) P. e185 Americas Population genetics Human history Text Article scientifique info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2007 ftunivgeneve https://doi.org/10.1371/journal.pgen.0030185 2022-06-19T23:38:26Z We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians—signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas. Article in Journal/Newspaper Bering Strait Université de Genève: Archive ouverte UNIGE Bering Strait PLoS Genetics 3 11 e185 |
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Open Polar |
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Université de Genève: Archive ouverte UNIGE |
op_collection_id |
ftunivgeneve |
language |
English |
topic |
Americas Population genetics Human history |
spellingShingle |
Americas Population genetics Human history Wang, Sijia Lewis, Cecil M. Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya, Gabriel Rojas, Winston Parra, Maria V. Molina, Julio A. Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana M. Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco M. Petzl-Erler, Maria Luiza Tsuneto, Luiza T. Llop, Elena Rothhammer, Francisco Excoffier, Laurent Georges Louis Feldman, Marcus W. Rosenberg, Noah A. Ruiz-Linares, Andrés Genetic Variation and Population Structure in Native Americans |
topic_facet |
Americas Population genetics Human history |
description |
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians—signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas. |
format |
Article in Journal/Newspaper |
author |
Wang, Sijia Lewis, Cecil M. Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya, Gabriel Rojas, Winston Parra, Maria V. Molina, Julio A. Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana M. Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco M. Petzl-Erler, Maria Luiza Tsuneto, Luiza T. Llop, Elena Rothhammer, Francisco Excoffier, Laurent Georges Louis Feldman, Marcus W. Rosenberg, Noah A. Ruiz-Linares, Andrés |
author_facet |
Wang, Sijia Lewis, Cecil M. Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya, Gabriel Rojas, Winston Parra, Maria V. Molina, Julio A. Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana M. Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco M. Petzl-Erler, Maria Luiza Tsuneto, Luiza T. Llop, Elena Rothhammer, Francisco Excoffier, Laurent Georges Louis Feldman, Marcus W. Rosenberg, Noah A. Ruiz-Linares, Andrés |
author_sort |
Wang, Sijia |
title |
Genetic Variation and Population Structure in Native Americans |
title_short |
Genetic Variation and Population Structure in Native Americans |
title_full |
Genetic Variation and Population Structure in Native Americans |
title_fullStr |
Genetic Variation and Population Structure in Native Americans |
title_full_unstemmed |
Genetic Variation and Population Structure in Native Americans |
title_sort |
genetic variation and population structure in native americans |
publishDate |
2007 |
url |
https://archive-ouverte.unige.ch/unige:18198 |
geographic |
Bering Strait |
geographic_facet |
Bering Strait |
genre |
Bering Strait |
genre_facet |
Bering Strait |
op_source |
ISSN: 1553-7390 PLOS genetics, Vol. 3, No 11 (2007) P. e185 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.0030185 unige:18198 https://archive-ouverte.unige.ch/unige:18198 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pgen.0030185 |
container_title |
PLoS Genetics |
container_volume |
3 |
container_issue |
11 |
container_start_page |
e185 |
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1766378534177079296 |