Norwegian Sami differs significantly from other Norwegians according to their HLA profile
This study reports extensive genomic data for both human leukocyte antigen (HLA) class I and II loci in Norwegian Sami, a native population living in the northwest of Europe. The Sami have a distinct culture and their own languages, which belong to the Uralic linguistic family. Norwegian Sami (n = 2...
Published in: | Tissue Antigens |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2010
|
Subjects: | |
Online Access: | https://archive-ouverte.unige.ch/unige:5189 |
id |
ftunivgeneve:oai:unige.ch:aou:unige:5189 |
---|---|
record_format |
openpolar |
spelling |
ftunivgeneve:oai:unige.ch:aou:unige:5189 2023-10-01T03:59:14+02:00 Norwegian Sami differs significantly from other Norwegians according to their HLA profile Harbo, H. F. Riccio, Maria Eugenia Lorentzen, A. R. Utsi, E. Myhr, K.-M. Mellgren, S. I. Flam, S. T. Thorsby, E. Sanchez-Mazas, Alicia Lie, B. A. 2010 https://archive-ouverte.unige.ch/unige:5189 eng eng info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1399-0039.2009.01425.x https://archive-ouverte.unige.ch/unige:5189 unige:5189 info:eu-repo/semantics/restrictedAccess ISSN: 0001-2815 Tissue antigens, vol. 75 (2010) p. 207-217 info:eu-repo/classification/ddc/599.9 info:eu-repo/classification/ddc/590 Genetic diversity Human leukocyte antigen Norwegian Population genetics Sami info:eu-repo/semantics/article Text Article scientifique info:eu-repo/semantics/publishedVersion 2010 ftunivgeneve https://doi.org/10.1111/j.1399-0039.2009.01425.x 2023-09-07T06:51:33Z This study reports extensive genomic data for both human leukocyte antigen (HLA) class I and II loci in Norwegian Sami, a native population living in the northwest of Europe. The Sami have a distinct culture and their own languages, which belong to the Uralic linguistic family. Norwegian Sami (n = 200) were typed at the DNA level for the HLA-A, -C, -B, -DRB1 and -DQB1 loci, and compared with a non- Sami Norwegian population (n = 576). The two populations exhibited some common genetic features but also differed significantly at all HLA loci. The most significantly deviating allele frequencies were an increase of HLA-A*03, -B*27, -DRB1*08 and -DQB1*04 and a decrease of HLA-A*01, C*01, -DRB1*04 and -DQB1*02 among Sami compared with non-Sami Norwegians. The Sami showed no deviation from Hardy–Weinberg equilibrium. The hypothesis of selective neutrality was rejected at all loci except for the A- and C- loci for the Sami. HLA haplotype frequencies also differed between the two populations. The most common extended HLA haplotypes were A*02-B*27-C*01-DR*08-DQB1*04 in the Sami and A*01-B*08-C*07-DR*03- DQB1*02 in the other Norwegians. Genetic distance analyses indicated that theNorwegian Sami were highly differentiated from other Europeans and were most closely related to Finns whose language also belongs to the Uralic linguistic family. In conclusion, the Norwegian Sami and the non-Sami Norwegians were significantly different at all HLA loci. Our results can be explained by the fact that the two populations have different origins and that the Sami population has remained smaller and more isolated than its neighbors. Article in Journal/Newspaper sami sami Université de Genève: Archive ouverte UNIGE Tissue Antigens 75 3 207 217 |
institution |
Open Polar |
collection |
Université de Genève: Archive ouverte UNIGE |
op_collection_id |
ftunivgeneve |
language |
English |
topic |
info:eu-repo/classification/ddc/599.9 info:eu-repo/classification/ddc/590 Genetic diversity Human leukocyte antigen Norwegian Population genetics Sami |
spellingShingle |
info:eu-repo/classification/ddc/599.9 info:eu-repo/classification/ddc/590 Genetic diversity Human leukocyte antigen Norwegian Population genetics Sami Harbo, H. F. Riccio, Maria Eugenia Lorentzen, A. R. Utsi, E. Myhr, K.-M. Mellgren, S. I. Flam, S. T. Thorsby, E. Sanchez-Mazas, Alicia Lie, B. A. Norwegian Sami differs significantly from other Norwegians according to their HLA profile |
topic_facet |
info:eu-repo/classification/ddc/599.9 info:eu-repo/classification/ddc/590 Genetic diversity Human leukocyte antigen Norwegian Population genetics Sami |
description |
This study reports extensive genomic data for both human leukocyte antigen (HLA) class I and II loci in Norwegian Sami, a native population living in the northwest of Europe. The Sami have a distinct culture and their own languages, which belong to the Uralic linguistic family. Norwegian Sami (n = 200) were typed at the DNA level for the HLA-A, -C, -B, -DRB1 and -DQB1 loci, and compared with a non- Sami Norwegian population (n = 576). The two populations exhibited some common genetic features but also differed significantly at all HLA loci. The most significantly deviating allele frequencies were an increase of HLA-A*03, -B*27, -DRB1*08 and -DQB1*04 and a decrease of HLA-A*01, C*01, -DRB1*04 and -DQB1*02 among Sami compared with non-Sami Norwegians. The Sami showed no deviation from Hardy–Weinberg equilibrium. The hypothesis of selective neutrality was rejected at all loci except for the A- and C- loci for the Sami. HLA haplotype frequencies also differed between the two populations. The most common extended HLA haplotypes were A*02-B*27-C*01-DR*08-DQB1*04 in the Sami and A*01-B*08-C*07-DR*03- DQB1*02 in the other Norwegians. Genetic distance analyses indicated that theNorwegian Sami were highly differentiated from other Europeans and were most closely related to Finns whose language also belongs to the Uralic linguistic family. In conclusion, the Norwegian Sami and the non-Sami Norwegians were significantly different at all HLA loci. Our results can be explained by the fact that the two populations have different origins and that the Sami population has remained smaller and more isolated than its neighbors. |
format |
Article in Journal/Newspaper |
author |
Harbo, H. F. Riccio, Maria Eugenia Lorentzen, A. R. Utsi, E. Myhr, K.-M. Mellgren, S. I. Flam, S. T. Thorsby, E. Sanchez-Mazas, Alicia Lie, B. A. |
author_facet |
Harbo, H. F. Riccio, Maria Eugenia Lorentzen, A. R. Utsi, E. Myhr, K.-M. Mellgren, S. I. Flam, S. T. Thorsby, E. Sanchez-Mazas, Alicia Lie, B. A. |
author_sort |
Harbo, H. F. |
title |
Norwegian Sami differs significantly from other Norwegians according to their HLA profile |
title_short |
Norwegian Sami differs significantly from other Norwegians according to their HLA profile |
title_full |
Norwegian Sami differs significantly from other Norwegians according to their HLA profile |
title_fullStr |
Norwegian Sami differs significantly from other Norwegians according to their HLA profile |
title_full_unstemmed |
Norwegian Sami differs significantly from other Norwegians according to their HLA profile |
title_sort |
norwegian sami differs significantly from other norwegians according to their hla profile |
publishDate |
2010 |
url |
https://archive-ouverte.unige.ch/unige:5189 |
genre |
sami sami |
genre_facet |
sami sami |
op_source |
ISSN: 0001-2815 Tissue antigens, vol. 75 (2010) p. 207-217 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1399-0039.2009.01425.x https://archive-ouverte.unige.ch/unige:5189 unige:5189 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1111/j.1399-0039.2009.01425.x |
container_title |
Tissue Antigens |
container_volume |
75 |
container_issue |
3 |
container_start_page |
207 |
op_container_end_page |
217 |
_version_ |
1778532933608407040 |