Geographic Patterns of mtDNA Diversity in Europe
Genetic diversity in Europe has been interpreted as a reflection of phenomena occurring during the Paleolithic (∼45,000 years before the present [BP]), Mesolithic (∼18,000 years BP), and Neolithic (∼10,000 years BP) periods. A crucial role of the Neolithic demographic transition is supported by the...
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ftunivgeneve:oai:unige.ch:aou:unige:137035 2023-10-01T03:59:12+02:00 Geographic Patterns of mtDNA Diversity in Europe Simoni, Lucia Calafell, Francesc Pettener, Davide Bertranpetit, Jaume Barbujani, Guido 2000 https://archive-ouverte.unige.ch/unige:137035 eng eng info:eu-repo/semantics/altIdentifier/doi/10.1086/302706 https://archive-ouverte.unige.ch/unige:137035 unige:137035 info:eu-repo/semantics/restrictedAccess ISSN: 0002-9297 American Journal of Human Genetics, vol. 66, no. 1 (2000) p. 262-278 info:eu-repo/semantics/article Text Article scientifique info:eu-repo/semantics/publishedVersion 2000 ftunivgeneve https://doi.org/10.1086/302706 2023-09-07T07:57:14Z Genetic diversity in Europe has been interpreted as a reflection of phenomena occurring during the Paleolithic (∼45,000 years before the present [BP]), Mesolithic (∼18,000 years BP), and Neolithic (∼10,000 years BP) periods. A crucial role of the Neolithic demographic transition is supported by the analysis of most nuclear loci, but the interpretation of mtDNA evidence is controversial. More than 2,600 sequences of the first hypervariable mitochondrial control region were analyzed for geographic patterns in samples from Europe, the Near East, and the Caucasus. Two autocorrelation statistics were used, one based on allele-frequency differences between samples and the other based on both sequence and frequency differences between alleles. In the global analysis, limited geographic patterning was observed, which could largely be attributed to a marked difference between the Saami and all other populations. The distribution of the zones of highest mitochondrial variation (genetic boundaries) confirmed that the Saami are sharply differentiated from an otherwise rather homogeneous set of European samples. However, an area of significant clinal variation was identified around the Mediterranean Sea (and not in the north), even though the differences between northern and southern populations were insignificant. Both a Paleolithic expansion and the Neolithic demic diffusion of farmers could have determined a longitudinal cline of mtDNA diversity. However, additional phenomena must be considered in both models, to account both for the north-south differences and for the greater geographic scope of clinal patterns at nuclear loci. Conversely, two predicted consequences of models of Mesolithic reexpansion from glacial refugia were not observed in the present study. Article in Journal/Newspaper saami Université de Genève: Archive ouverte UNIGE The American Journal of Human Genetics 66 1 262 278 |
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Université de Genève: Archive ouverte UNIGE |
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English |
description |
Genetic diversity in Europe has been interpreted as a reflection of phenomena occurring during the Paleolithic (∼45,000 years before the present [BP]), Mesolithic (∼18,000 years BP), and Neolithic (∼10,000 years BP) periods. A crucial role of the Neolithic demographic transition is supported by the analysis of most nuclear loci, but the interpretation of mtDNA evidence is controversial. More than 2,600 sequences of the first hypervariable mitochondrial control region were analyzed for geographic patterns in samples from Europe, the Near East, and the Caucasus. Two autocorrelation statistics were used, one based on allele-frequency differences between samples and the other based on both sequence and frequency differences between alleles. In the global analysis, limited geographic patterning was observed, which could largely be attributed to a marked difference between the Saami and all other populations. The distribution of the zones of highest mitochondrial variation (genetic boundaries) confirmed that the Saami are sharply differentiated from an otherwise rather homogeneous set of European samples. However, an area of significant clinal variation was identified around the Mediterranean Sea (and not in the north), even though the differences between northern and southern populations were insignificant. Both a Paleolithic expansion and the Neolithic demic diffusion of farmers could have determined a longitudinal cline of mtDNA diversity. However, additional phenomena must be considered in both models, to account both for the north-south differences and for the greater geographic scope of clinal patterns at nuclear loci. Conversely, two predicted consequences of models of Mesolithic reexpansion from glacial refugia were not observed in the present study. |
format |
Article in Journal/Newspaper |
author |
Simoni, Lucia Calafell, Francesc Pettener, Davide Bertranpetit, Jaume Barbujani, Guido |
spellingShingle |
Simoni, Lucia Calafell, Francesc Pettener, Davide Bertranpetit, Jaume Barbujani, Guido Geographic Patterns of mtDNA Diversity in Europe |
author_facet |
Simoni, Lucia Calafell, Francesc Pettener, Davide Bertranpetit, Jaume Barbujani, Guido |
author_sort |
Simoni, Lucia |
title |
Geographic Patterns of mtDNA Diversity in Europe |
title_short |
Geographic Patterns of mtDNA Diversity in Europe |
title_full |
Geographic Patterns of mtDNA Diversity in Europe |
title_fullStr |
Geographic Patterns of mtDNA Diversity in Europe |
title_full_unstemmed |
Geographic Patterns of mtDNA Diversity in Europe |
title_sort |
geographic patterns of mtdna diversity in europe |
publishDate |
2000 |
url |
https://archive-ouverte.unige.ch/unige:137035 |
genre |
saami |
genre_facet |
saami |
op_source |
ISSN: 0002-9297 American Journal of Human Genetics, vol. 66, no. 1 (2000) p. 262-278 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1086/302706 https://archive-ouverte.unige.ch/unige:137035 unige:137035 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1086/302706 |
container_title |
The American Journal of Human Genetics |
container_volume |
66 |
container_issue |
1 |
container_start_page |
262 |
op_container_end_page |
278 |
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1778532835112517632 |