BiocatalyticProduction of Chiral Benzotriazoles Employing Conventional Heating and Microwave Radiation

• Published in: Current Microwave Chemistry
• Main Authors: Meirelles, Matheus A., Jeller, Alex H., Ferreira, Irlon M., Raminelli, Cristiano, Faria, Raquel S., Silveira-Lacerda, Elisangela de Paula, Porto, Andre L. M.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Bentham Science Publ Ltd 2017
• Subjects: 1,2,3-benzotriazoles; biocatalysis; CAL-B; microwave radiation; beta-azidoalcohols; Rua; Antarc*; Antarctica
• Online Access: https://repositorio.unifesp.br/handle/11600/55469; https://doi.org/10.2174/2213335603666161101152243

Background: This paper describes the synthesis of chiral 1,2,3-benzotriazoles by the enzymatic kinetic resolution of beta-azidoalcohols using lipase from Candida antarctica B followed by a [3+ 2] cycloaddition reaction involving benzyne formation from 2-(trimethylsilyl) phenyl triflate and CsF under...