Effect of Nateglinide on the Incidence of Diabetes and Cardiovascular Events

• Published in: New England Journal of Medicine
• Main Authors: Holman, Rury R., Haffner, Steven M., McMurray, John J., Bethel, M. Angelyn, Holzhauer, Bjoern, Hua, Tsushung A., Belenkov, Yuri, Boolell, Mitradev, Buse, John B., Buckley, Brendan M., Chacra, Antonio R., Chiang, Fu-Tien, Charbonnel, Bernard, Chow, Chun-Chung, Davies, Melanie J., Deedwania, Prakash, Diem, Peter, Einhorn, Daniel, Fonseca, Vivian, Fulcher, Gregory R., Gaciong, Zbigniew, Gaztambide, Sonia, Giles, Thomas, Horton, Edward, Ilkova, Hasan, Jenssen, Trond, Kahn, Steven E., Krum, Henry, Laakso, Markku, Leiter, Lawrence A., Levitt, Naomi S., Mareev, Viacheslav, Martinez, Felipe, Masson, Chantal, Mazzone, Theodore, Meaney, Eduardo, Nesto, Richard, Pan, Changyu, Prager, Rudolf, Raptis, Sotirios A., Rutten, Guy E. H. M., Sandstroem, Herbert, Schaper, Frank, Scheen, Andre, Schmitz, Ole, Sinay, Isaac, Soska, Vladimir, Stender, Steen, Tamas, Gyula, Tognoni, Gianni, Tuomilehto, Jaako, Villamil, Alberto S., Vozar, Juraj, Califf, Robert M., NAVIGATOR Study Grp
• Other Authors: Univ Oxford, Univ Glasgow, Univ Leicester, Univ Texas Hlth Sci Ctr San Antonio, Duke Univ, Univ N Carolina, Novartis Pharmaceut, Univ Hosp Bern, Univ Bern, Moscow MV Lomonosov State Univ, Natl Univ Ireland Univ Coll Cork, Universidade Federal de São Paulo (UNIFESP), Natl Taiwan Univ Hosp, Univ Hosp, Chinese Univ Hong Kong, 301 Hosp, Calif State Univ Fresno, VA Cent Calif Hlth Care Syst, Univ Calif San Diego, Scripps Whittier Diabet Inst, Tulane Univ, Univ Sydney, Monash Univ, Warsaw Med Univ, Hosp Univ Cruces, Joslin Diabet Ctr, Istanbul Univ, Oslo Univ Hosp, Univ Tromso, VA Puget Sound Hlth Care Syst, Univ Washington, Univ Kuopio, Kuopio Univ Hosp, Univ Helsinki, S Ostrobothnia Cent Hosp, Univ Toronto, Univ Cape Town, Natl Univ Cordoba, Univ Buenos Aires, Univ Illinois, Hosp 10 Octubre, Lahey Clin Fdn, Krankenhaus Hietzing Neurolog, Attikon Univ Hosp, Univ Med Ctr, Umea Univ, Tech Univ Dresden, Univ Liege, Aarhus Univ, Univ Copenhagen
• Format: Article in Journal/Newspaper
• Language: English
• Published: Massachusetts Medical Soc 2010
• Subjects: Argentina; Burlington; Canada; Chapel Hill; Leicester; Norway; Orleans; Scripps; Tromso
• Online Access: http://repositorio.unifesp.br/handle/11600/32480; https://doi.org/10.1056/NEJMoa1001122

BACKGROUNDThe ability of short-acting insulin secretagogues to reduce the risk of diabetes or cardiovascular events in people with impaired glucose tolerance is unknown.METHODSIn a double-blind, randomized clinical trial, we assigned 9306 participants with impaired glucose tolerance and either cardi...