Effect of Valsartan on the Incidence of Diabetes and Cardiovascular Events

• Published in: New England Journal of Medicine
• Main Authors: McMurray, John J., Holman, Rury R., Haffner, Steven M., Bethel, M. Angelyn, Holzhauer, Bjoern, Hua, Tsushung A., Belenkov, Yuri, Boolell, Mitradev, Buse, John B., Buckley, Brendan M., Chacra, Antonio R., Chiang, Fu-Tien, Charbonnel, Bernard, Chow, Chun-Chung, Davies, Melanie J., Deedwania, Prakash, Diem, Peter, Einhorn, Daniel, Fonseca, Vivian, Fulcher, Gregory R., Gaciong, Zbigniew, Gaztambide, Sonia, Giles, Thomas, Horton, Edward, Ilkova, Hasan, Jenssen, Trond, Kahn, Steven E., Krum, Henry, Laakso, Markku, Leiter, Lawrence A., Levitt, Naomi S., Mareev, Viacheslav, Martinez, Felipe, Masson, Chantal, Mazzone, Theodore, Meaney, Eduardo, Nesto, Richard, Pan, Changyu, Prager, Rudolf, Raptis, Sotirios A., Rutten, Guy E. H. M., Sandstroem, Herbert, Schaper, Frank, Scheen, Andre, Schmitz, Ole, Sinay, Isaac, Soska, Vladimir, Stender, Steen, Tamas, Gyula, Tognoni, Gianni, Tuomilehto, Jaako, Villamil, Alberto S., Vozar, Juraj, Califf, Robert M., NAVIGATOR Study Grp
• Other Authors: Univ Glasgow, Univ Oxford, Univ Texas Hlth Sci Ctr San Antonio, Duke Univ, Novartis Pharmaceut, Moscow MV Lomonosov State Univ, Univ N Carolina, Natl Univ Ireland Univ Coll Cork, Universidade Federal de São Paulo (UNIFESP), Natl Taiwan Univ Hosp, Univ Hosp, Chinese Univ Hong Kong, Univ Leicester, Calif State Univ Fresno, VA Cent Calif Hlth Care Syst, Univ Hosp Bern, Univ Bern, Univ Calif San Diego, Scripps Whittier Diabet Inst, Tulane Univ, Univ Sydney, Warsaw Med Univ, Hosp Univ Cruces, Joslin Diabet Ctr, Istanbul Univ, Oslo Univ Hosp, Univ Tromso, VA Puget Sound Hlth Care Syst, Univ Washington, Monash Univ, Univ Kuopio, Kuopio Univ Hosp, Univ Toronto, Univ Cape Town, Natl Univ Cordoba, Univ Illinois, Hosp Primero Octubre, Lahey Clin Fdn, 301 Hosp, Krankenhaus Hietzing Neurol, Attikon Univ Hosp, Univ Med Ctr, Umea Univ, Tech Univ Dresden, Univ Liege, Aarhus Univ, Inst Cardiovasc Buenos Aires, Fac Hosp St Anna, Univ Copenhagen, Semmelweis Univ
• Format: Article in Journal/Newspaper
• Language: English
• Published: Massachusetts Medical Soc 2010
• Subjects: Argentina; Burlington; Canada; Chapel Hill; Leicester; Norway; Orleans; Scripps; Tromso
• Online Access: http://repositorio.unifesp.br/handle/11600/32479; https://doi.org/10.1056/NEJMoa1001121

BACKGROUNDIt is not known whether drugs that block the renin-angiotensin system reduce the risk of diabetes and cardiovascular events in patients with impaired glucose tolerance.METHODSIn this double-blind, randomized clinical trial with a 2-by-2 factorial design, we assigned 9306 patients with impa...