Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9
A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 59and 39flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information availab...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2011
|
Subjects: | |
Online Access: | http://hdl.handle.net/10183/225251 |
id |
ftunivfrgs:oai:www.lume.ufrgs.br:10183/225251 |
---|---|
record_format |
openpolar |
spelling |
ftunivfrgs:oai:www.lume.ufrgs.br:10183/225251 2023-10-09T21:51:12+02:00 Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 Paixão Côrtes, Vanessa Rodrigues Meyer, Diogo Pereira, Tiago da Veiga Mazières, Stéphane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco Antonio Silva Junior, Wilson Araujo da Salzano, Francisco Mauro Bortolini, Maria Cátira 2011 application/pdf http://hdl.handle.net/10183/225251 eng eng PLoS ONE. San Francisco. Vol. 6, no. 1 (Jan. 2011), e15656, 7 p. 1932-6203 http://hdl.handle.net/10183/225251 000828330 Open Access Genética de populações Evolução humana Gene PAX9 Artigo de periódico Estrangeiro 2011 ftunivfrgs 2023-09-23T23:16:08Z A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 59and 39flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works. Article in Journal/Newspaper eskimo* Universidade Federal do Rio Grande do Sul (UFRGS): Lume |
institution |
Open Polar |
collection |
Universidade Federal do Rio Grande do Sul (UFRGS): Lume |
op_collection_id |
ftunivfrgs |
language |
English |
topic |
Genética de populações Evolução humana Gene PAX9 |
spellingShingle |
Genética de populações Evolução humana Gene PAX9 Paixão Côrtes, Vanessa Rodrigues Meyer, Diogo Pereira, Tiago da Veiga Mazières, Stéphane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco Antonio Silva Junior, Wilson Araujo da Salzano, Francisco Mauro Bortolini, Maria Cátira Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
topic_facet |
Genética de populações Evolução humana Gene PAX9 |
description |
A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 59and 39flanking intronic segments (232 bp and 220 bp, respectively) and integrated with the information available for the same genetic region from individuals of different geographical origins. Nine mutations were scored in exon 3 and six in its flanking regions; four of them are new South American tribe-specific singletons. Exon3 nucleotide diversity is several orders of magnitude higher than its intronic regions. Additionally, a set of variants in the PAX9 and 101 other genes related with dentition can define at least some dental morphological differences between Sub-Saharan Africans and non-Africans, probably associated with adaptations after the modern human exodus from Africa. Exon 3 of PAX9 could be a good molecular example of how evolvability works. |
format |
Article in Journal/Newspaper |
author |
Paixão Côrtes, Vanessa Rodrigues Meyer, Diogo Pereira, Tiago da Veiga Mazières, Stéphane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco Antonio Silva Junior, Wilson Araujo da Salzano, Francisco Mauro Bortolini, Maria Cátira |
author_facet |
Paixão Côrtes, Vanessa Rodrigues Meyer, Diogo Pereira, Tiago da Veiga Mazières, Stéphane Elion, Jacques Krishnamoorthy, Rajagopal Zago, Marco Antonio Silva Junior, Wilson Araujo da Salzano, Francisco Mauro Bortolini, Maria Cátira |
author_sort |
Paixão Côrtes, Vanessa Rodrigues |
title |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title_short |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title_full |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title_fullStr |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title_full_unstemmed |
Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9 |
title_sort |
genetic variation among major human geographic groups supports a peculiar evolutionary trend in pax9 |
publishDate |
2011 |
url |
http://hdl.handle.net/10183/225251 |
genre |
eskimo* |
genre_facet |
eskimo* |
op_relation |
PLoS ONE. San Francisco. Vol. 6, no. 1 (Jan. 2011), e15656, 7 p. 1932-6203 http://hdl.handle.net/10183/225251 000828330 |
op_rights |
Open Access |
_version_ |
1779314310353256448 |