Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#

• Main Authors: Yibo Xu (1763989), Dongyang Wang (134365), Qianqian Lv (3840769), Peng Fu (417962), Ying Wang (11406), Weiming Zhu (391049)
• Format: Other Non-Article Part of Journal/Newspaper
• Language: unknown
• Published: 2022
• Subjects: Biochemistry; Medicine; Ecology; Hematology; Plant Biology; Virology; Environmental Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; selective antiproliferative activity; hucct1 cell lines; bridged dimeric polyketides; 3 </ b; 2 </ b; e .; phaeochromycins; 50 </ sub; streptomyces </; – k; values ranging; three methylene; hresims data; exhibiting ic; culture broth; analyzing one; 52 μm; permafrost
• Online Access: https://doi.org/10.1021/acsomega.2c07038.s001

Three new dimeric polyketides, i.e., phaeochromycins I–K ( 1 – 3 , respectively) and a known polyketide phaeochromycin F ( 4 ), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimensional and two-dimensional NMR as well as HRESIMS data. Compounds 2 and 3 exhibited a selective antiproliferative activity against H1299 and HUCCT1 cell lines, exhibiting IC 50 values ranging from 8.83 to 10.52 μM.