Biological activities of ethanolic extracts from deep-sea antarctic marine sponges
We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically...
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ftunivfrankfurt:oai:publikationen.ub.uni-frankfurt.de:26347 2023-05-15T13:41:08+02:00 Biological activities of ethanolic extracts from deep-sea antarctic marine sponges Turk, Tom Ambrožič Avguštin, Jerneja Batista, Urška Strugar, Gašper Kosmina, Rok Čivović, Sandra Janussen, Dorte Kauferstein, Silke Mebs, Dietrich Sepčić, Kristina 2013-04-02 application/pdf http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26347 https://nbn-resolving.org/urn:nbn:de:hebis:30:3-263470 https://doi.org/10.3390/md11041126 http://publikationen.ub.uni-frankfurt.de/files/26347/marinedrugs-11-01126.pdf eng eng http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26347 urn:nbn:de:hebis:30:3-263470 https://nbn-resolving.org/urn:nbn:de:hebis:30:3-263470 https://doi.org/10.3390/md11041126 http://publikationen.ub.uni-frankfurt.de/files/26347/marinedrugs-11-01126.pdf http://creativecommons.org/licenses/by/3.0/de/deed.de info:eu-repo/semantics/openAccess CC-BY ddc:570 article doc-type:article 2013 ftunivfrankfurt https://doi.org/10.3390/md11041126 2022-09-11T23:01:23Z We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically and ecologically relevant bacteria. The most prominent activities were associated with the extracts from sponges belonging to the genus Latrunculia, which show all of these activities. While most of these activities are associated to already known secondary metabolites, the extremely strong acetylcholinesterase inhibitory potential appears to be related to a compound unknown to date. Extracts from Tetilla leptoderma, Bathydorus cf. spinosus, Xestospongia sp., Rossella sp., Rossella cf. racovitzae and Halichondria osculum were hemolytic, with the last two also showing moderate cytotoxic potential. The antibacterial tests showed significantly greater activities of the extracts of these Antarctic sponges towards ecologically relevant bacteria from sea water and from Arctic ice. This indicates their ecological relevance for inhibition of bacterial microfouling. Article in Journal/Newspaper Antarc* Antarctic Arctic Publication Server of Goethe University Frankfurt am Main Antarctic Arctic Marine Drugs 11 12 1126 1139 |
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Open Polar |
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Publication Server of Goethe University Frankfurt am Main |
op_collection_id |
ftunivfrankfurt |
language |
English |
topic |
ddc:570 |
spellingShingle |
ddc:570 Turk, Tom Ambrožič Avguštin, Jerneja Batista, Urška Strugar, Gašper Kosmina, Rok Čivović, Sandra Janussen, Dorte Kauferstein, Silke Mebs, Dietrich Sepčić, Kristina Biological activities of ethanolic extracts from deep-sea antarctic marine sponges |
topic_facet |
ddc:570 |
description |
We report on the screening of ethanolic extracts from 33 deep-sea Antarctic marine sponges for different biological activities. We monitored hemolysis, inhibition of acetylcholinesterase, cytotoxicity towards normal and transformed cells and growth inhibition of laboratory, commensal and clinically and ecologically relevant bacteria. The most prominent activities were associated with the extracts from sponges belonging to the genus Latrunculia, which show all of these activities. While most of these activities are associated to already known secondary metabolites, the extremely strong acetylcholinesterase inhibitory potential appears to be related to a compound unknown to date. Extracts from Tetilla leptoderma, Bathydorus cf. spinosus, Xestospongia sp., Rossella sp., Rossella cf. racovitzae and Halichondria osculum were hemolytic, with the last two also showing moderate cytotoxic potential. The antibacterial tests showed significantly greater activities of the extracts of these Antarctic sponges towards ecologically relevant bacteria from sea water and from Arctic ice. This indicates their ecological relevance for inhibition of bacterial microfouling. |
format |
Article in Journal/Newspaper |
author |
Turk, Tom Ambrožič Avguštin, Jerneja Batista, Urška Strugar, Gašper Kosmina, Rok Čivović, Sandra Janussen, Dorte Kauferstein, Silke Mebs, Dietrich Sepčić, Kristina |
author_facet |
Turk, Tom Ambrožič Avguštin, Jerneja Batista, Urška Strugar, Gašper Kosmina, Rok Čivović, Sandra Janussen, Dorte Kauferstein, Silke Mebs, Dietrich Sepčić, Kristina |
author_sort |
Turk, Tom |
title |
Biological activities of ethanolic extracts from deep-sea antarctic marine sponges |
title_short |
Biological activities of ethanolic extracts from deep-sea antarctic marine sponges |
title_full |
Biological activities of ethanolic extracts from deep-sea antarctic marine sponges |
title_fullStr |
Biological activities of ethanolic extracts from deep-sea antarctic marine sponges |
title_full_unstemmed |
Biological activities of ethanolic extracts from deep-sea antarctic marine sponges |
title_sort |
biological activities of ethanolic extracts from deep-sea antarctic marine sponges |
publishDate |
2013 |
url |
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26347 https://nbn-resolving.org/urn:nbn:de:hebis:30:3-263470 https://doi.org/10.3390/md11041126 http://publikationen.ub.uni-frankfurt.de/files/26347/marinedrugs-11-01126.pdf |
geographic |
Antarctic Arctic |
geographic_facet |
Antarctic Arctic |
genre |
Antarc* Antarctic Arctic |
genre_facet |
Antarc* Antarctic Arctic |
op_relation |
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/26347 urn:nbn:de:hebis:30:3-263470 https://nbn-resolving.org/urn:nbn:de:hebis:30:3-263470 https://doi.org/10.3390/md11041126 http://publikationen.ub.uni-frankfurt.de/files/26347/marinedrugs-11-01126.pdf |
op_rights |
http://creativecommons.org/licenses/by/3.0/de/deed.de info:eu-repo/semantics/openAccess |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3390/md11041126 |
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Marine Drugs |
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11 |
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12 |
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1126 |
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