Free DNA, a reason for severe COVID-19 infection?
The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. Howev...
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ftunivflavras:oai:localhost:1/41711 2023-06-11T04:06:37+02:00 Free DNA, a reason for severe COVID-19 infection? Liu, Bin 2020-09 http://repositorio.ufla.br/jspui/handle/1/41711 https://www.sciencedirect.com/science/article/pii/S030698772030390X en_US eng Elsevier LIU, B. Free DNA, a reason for severe COVID-19 infection? Medical Hypotheses, [S.l.], v. 142, Sept. 2020. https://www.sciencedirect.com/science/article/pii/S030698772030390X http://repositorio.ufla.br/jspui/handle/1/41711 restrictAccess Medical Hypotheses COVID-19 Free DNA Artigo 2020 ftunivflavras 2023-05-29T09:38:35Z The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. However, the etiology of severe COVID-19 has been largely unknown. Similar as SARS-CoV and MERS-CoV, SARS-CoV-2 is also thought derived from bat coronaviruses. However, it is not pathogenic for bat at all, because free DNA in cytoplasm or blood cannot bring up violent immune response in bat; but it can produce severe inflammations in human. I hypothesized that the damage induced by free DNA is a reason for severe COVID-19, which can explain many symptoms of this disease, such as cytokine storm, acute respiratory distress syndrome (ARDS) and muscus plug, acute injuries of heart, liver and kidney, and some special symptoms of COVID-19. My hypothesis will be helpful for better understand the etiology of severe COVID-19. Article in Journal/Newspaper Antarc* Antarctica Repositório Institucional da Universidade Federal de Lavras (RIUFLA) |
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Repositório Institucional da Universidade Federal de Lavras (RIUFLA) |
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ftunivflavras |
language |
English |
topic |
COVID-19 Free DNA |
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COVID-19 Free DNA Liu, Bin Free DNA, a reason for severe COVID-19 infection? |
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COVID-19 Free DNA |
description |
The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. However, the etiology of severe COVID-19 has been largely unknown. Similar as SARS-CoV and MERS-CoV, SARS-CoV-2 is also thought derived from bat coronaviruses. However, it is not pathogenic for bat at all, because free DNA in cytoplasm or blood cannot bring up violent immune response in bat; but it can produce severe inflammations in human. I hypothesized that the damage induced by free DNA is a reason for severe COVID-19, which can explain many symptoms of this disease, such as cytokine storm, acute respiratory distress syndrome (ARDS) and muscus plug, acute injuries of heart, liver and kidney, and some special symptoms of COVID-19. My hypothesis will be helpful for better understand the etiology of severe COVID-19. |
format |
Article in Journal/Newspaper |
author |
Liu, Bin |
author_facet |
Liu, Bin |
author_sort |
Liu, Bin |
title |
Free DNA, a reason for severe COVID-19 infection? |
title_short |
Free DNA, a reason for severe COVID-19 infection? |
title_full |
Free DNA, a reason for severe COVID-19 infection? |
title_fullStr |
Free DNA, a reason for severe COVID-19 infection? |
title_full_unstemmed |
Free DNA, a reason for severe COVID-19 infection? |
title_sort |
free dna, a reason for severe covid-19 infection? |
publisher |
Elsevier |
publishDate |
2020 |
url |
http://repositorio.ufla.br/jspui/handle/1/41711 https://www.sciencedirect.com/science/article/pii/S030698772030390X |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Medical Hypotheses |
op_relation |
LIU, B. Free DNA, a reason for severe COVID-19 infection? Medical Hypotheses, [S.l.], v. 142, Sept. 2020. https://www.sciencedirect.com/science/article/pii/S030698772030390X http://repositorio.ufla.br/jspui/handle/1/41711 |
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