Helicobacter pylori’s historical journey through Siberia and the Americas
The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human...
Published in: | Proceedings of the National Academy of Sciences |
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Online Access: | https://hdl.handle.net/11392/2480253 https://doi.org/10.1073/pnas.2015523118 https://www.pnas.org/doi/full/10.1073/pnas.2015523118 |
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ftunivferrarair:oai:iris.unife.it:11392/2480253 2024-02-11T10:02:33+01:00 Helicobacter pylori’s historical journey through Siberia and the Americas Moodley Y. Brunelli A. Ghirotto S. Klyubin A. Maady A. S. Tyne W. Munoz-Ramirez Z. Y. Zhou Z. Manica A. Linz B. Achtman M. Moodley, Y. Brunelli, A. Ghirotto, S. Klyubin, A. Maady, A. S. Tyne, W. Munoz-Ramirez, Z. Y. Zhou, Z. Manica, A. Linz, B. Achtman, M. 2021 STAMPA https://hdl.handle.net/11392/2480253 https://doi.org/10.1073/pnas.2015523118 https://www.pnas.org/doi/full/10.1073/pnas.2015523118 eng eng info:eu-repo/semantics/altIdentifier/pmid/34161258 info:eu-repo/semantics/altIdentifier/wos/WOS:000671755600002 volume:118 issue:25 firstpage:e2015523118-1 lastpage:e2015523118-9 numberofpages:9 journal:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA https://hdl.handle.net/11392/2480253 doi:10.1073/pnas.2015523118 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85107938999 https://www.pnas.org/doi/full/10.1073/pnas.2015523118 info:eu-repo/semantics/openAccess Helicobacter pylori Siberia Americas colonization demographic model Biological Evolution Multilocus Sequence Typing info:eu-repo/semantics/article 2021 ftunivferrarair https://doi.org/10.1073/pnas.2015523118 2024-01-17T17:41:43Z The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human populations across Siberia to help resolve whether ancient northern Eurasian populations persisted at high latitudes through the last glacial maximum and the relationships between present-day Siberians and Native Americans. A total of 556 strains were cultivated and genotyped by multilocus sequence typing, and 54 representative draft genomes were sequenced. The genetic diversity across Eurasia and the Americas was structured into three populations: hpAsia2, hpEastAsia, and hpNorthAsia. hpNorthAsia is closely related to the subpopulation hspIndigenousAmericas from Native Americans. Siberian bacteria were structured into five other subpopulations, two of which evolved through a divergence from hpAsia2 and hpNorthAsia, while three originated though Holocene admixture. The presence of both anciently diverged and recently admixed strains across Siberia support both Pleistocene persistence and Holocene recolonization. We also show that hspIndigenousAmericas is endemic in human populations across northern Eurasia. The evolutionary history of hspIndigenousAmericas was reconstructed using approximate Bayesian computation, which showed that it colonized the New World in a single migration event associated with a severe demographic bottleneck followed by low levels of recent admixture across the Bering Strait. Article in Journal/Newspaper Bering Strait Siberia Università degli Studi di Ferrara: CINECA IRIS Bering Strait Proceedings of the National Academy of Sciences 118 25 |
institution |
Open Polar |
collection |
Università degli Studi di Ferrara: CINECA IRIS |
op_collection_id |
ftunivferrarair |
language |
English |
topic |
Helicobacter pylori Siberia Americas colonization demographic model Biological Evolution Multilocus Sequence Typing |
spellingShingle |
Helicobacter pylori Siberia Americas colonization demographic model Biological Evolution Multilocus Sequence Typing Moodley Y. Brunelli A. Ghirotto S. Klyubin A. Maady A. S. Tyne W. Munoz-Ramirez Z. Y. Zhou Z. Manica A. Linz B. Achtman M. Helicobacter pylori’s historical journey through Siberia and the Americas |
topic_facet |
Helicobacter pylori Siberia Americas colonization demographic model Biological Evolution Multilocus Sequence Typing |
description |
The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human populations across Siberia to help resolve whether ancient northern Eurasian populations persisted at high latitudes through the last glacial maximum and the relationships between present-day Siberians and Native Americans. A total of 556 strains were cultivated and genotyped by multilocus sequence typing, and 54 representative draft genomes were sequenced. The genetic diversity across Eurasia and the Americas was structured into three populations: hpAsia2, hpEastAsia, and hpNorthAsia. hpNorthAsia is closely related to the subpopulation hspIndigenousAmericas from Native Americans. Siberian bacteria were structured into five other subpopulations, two of which evolved through a divergence from hpAsia2 and hpNorthAsia, while three originated though Holocene admixture. The presence of both anciently diverged and recently admixed strains across Siberia support both Pleistocene persistence and Holocene recolonization. We also show that hspIndigenousAmericas is endemic in human populations across northern Eurasia. The evolutionary history of hspIndigenousAmericas was reconstructed using approximate Bayesian computation, which showed that it colonized the New World in a single migration event associated with a severe demographic bottleneck followed by low levels of recent admixture across the Bering Strait. |
author2 |
Moodley, Y. Brunelli, A. Ghirotto, S. Klyubin, A. Maady, A. S. Tyne, W. Munoz-Ramirez, Z. Y. Zhou, Z. Manica, A. Linz, B. Achtman, M. |
format |
Article in Journal/Newspaper |
author |
Moodley Y. Brunelli A. Ghirotto S. Klyubin A. Maady A. S. Tyne W. Munoz-Ramirez Z. Y. Zhou Z. Manica A. Linz B. Achtman M. |
author_facet |
Moodley Y. Brunelli A. Ghirotto S. Klyubin A. Maady A. S. Tyne W. Munoz-Ramirez Z. Y. Zhou Z. Manica A. Linz B. Achtman M. |
author_sort |
Moodley Y. |
title |
Helicobacter pylori’s historical journey through Siberia and the Americas |
title_short |
Helicobacter pylori’s historical journey through Siberia and the Americas |
title_full |
Helicobacter pylori’s historical journey through Siberia and the Americas |
title_fullStr |
Helicobacter pylori’s historical journey through Siberia and the Americas |
title_full_unstemmed |
Helicobacter pylori’s historical journey through Siberia and the Americas |
title_sort |
helicobacter pylori’s historical journey through siberia and the americas |
publishDate |
2021 |
url |
https://hdl.handle.net/11392/2480253 https://doi.org/10.1073/pnas.2015523118 https://www.pnas.org/doi/full/10.1073/pnas.2015523118 |
geographic |
Bering Strait |
geographic_facet |
Bering Strait |
genre |
Bering Strait Siberia |
genre_facet |
Bering Strait Siberia |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/34161258 info:eu-repo/semantics/altIdentifier/wos/WOS:000671755600002 volume:118 issue:25 firstpage:e2015523118-1 lastpage:e2015523118-9 numberofpages:9 journal:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA https://hdl.handle.net/11392/2480253 doi:10.1073/pnas.2015523118 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85107938999 https://www.pnas.org/doi/full/10.1073/pnas.2015523118 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1073/pnas.2015523118 |
container_title |
Proceedings of the National Academy of Sciences |
container_volume |
118 |
container_issue |
25 |
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1790598577766006784 |