Fish cells involved in mucosal immunity against enteric helminths.
In recent decades, the mucosal immunology of higher vertebrates has been an intensively explored area of research and yet little is known regarding this in fish. The intestinal mucosa is continuously exposed to a broad spectrum of antigens derived from ingested food, water, commensal flora and patho...
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ftunivferrarair:oai:iris.unife.it:11392/2330462 2024-02-11T09:55:34+01:00 Fish cells involved in mucosal immunity against enteric helminths. SAYYAF DEZFULI, Bahram GIARI, Luisa Bosi, G Manera, M SAYYAF DEZFULI, Bahram Bosi, G Manera, M Giari, Luisa 2015 ELETTRONICO http://hdl.handle.net/11392/2330462 eng eng University of Valencia country:ESP ispartofbook:9th International Symposium on Fish Parasites. Book of abstracts 9th International Symposium on Fish Parasites firstpage:81 lastpage:81 numberofpages:1 http://hdl.handle.net/11392/2330462 info:eu-repo/semantics/conferenceObject 2015 ftunivferrarair 2024-01-17T17:36:05Z In recent decades, the mucosal immunology of higher vertebrates has been an intensively explored area of research and yet little is known regarding this in fish. The intestinal mucosa is continuously exposed to a broad spectrum of antigens derived from ingested food, water, commensal flora and pathogens. Recent comparative histological and ultrastructural studies on the uninfected intestines of chub Squalius cephalus, European eels Anguilla anguilla, and catfish Silurus glanis and in conspecifics naturally infected with acanthocephalans and platyhelminths, however, have begun to explore this. Endoparasitic helminths frequently cause intestinal inflammation inducing the recruitment of various immune cells to the site of infection. In each of the fish-helminth systems that were studied, a massive hyperplastic granulocyte response involving mast cells (MCs) and neutrophils in the epithelia, lamina propria and submucosa was seen in close proximity to the point of parasite attachment. An increase in the number of rodlet cells (RCs) in the intestinal epithelium of parasite-infected specimens was also seen. Hyperplasia and hypertrophy of mucous cells in infected intestines was evident. In transmission electron microscopy sections of all three infected fish hosts, MCs and mucous cells were frequently seen in contact with one another with evident degranulation of those MCs in close proximity to mucous cells. In fish the mechanism by which mucosal MCs might induce the secretion of excess mucus is unknown and is the main focus of this study. The role of MCs, neutrophils, RCs and mucous cells in the mucosal immune system of fish will be discussed. Conference Object Anguilla anguilla Università degli Studi di Ferrara: CINECA IRIS |
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Università degli Studi di Ferrara: CINECA IRIS |
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English |
description |
In recent decades, the mucosal immunology of higher vertebrates has been an intensively explored area of research and yet little is known regarding this in fish. The intestinal mucosa is continuously exposed to a broad spectrum of antigens derived from ingested food, water, commensal flora and pathogens. Recent comparative histological and ultrastructural studies on the uninfected intestines of chub Squalius cephalus, European eels Anguilla anguilla, and catfish Silurus glanis and in conspecifics naturally infected with acanthocephalans and platyhelminths, however, have begun to explore this. Endoparasitic helminths frequently cause intestinal inflammation inducing the recruitment of various immune cells to the site of infection. In each of the fish-helminth systems that were studied, a massive hyperplastic granulocyte response involving mast cells (MCs) and neutrophils in the epithelia, lamina propria and submucosa was seen in close proximity to the point of parasite attachment. An increase in the number of rodlet cells (RCs) in the intestinal epithelium of parasite-infected specimens was also seen. Hyperplasia and hypertrophy of mucous cells in infected intestines was evident. In transmission electron microscopy sections of all three infected fish hosts, MCs and mucous cells were frequently seen in contact with one another with evident degranulation of those MCs in close proximity to mucous cells. In fish the mechanism by which mucosal MCs might induce the secretion of excess mucus is unknown and is the main focus of this study. The role of MCs, neutrophils, RCs and mucous cells in the mucosal immune system of fish will be discussed. |
author2 |
SAYYAF DEZFULI, Bahram Bosi, G Manera, M Giari, Luisa |
format |
Conference Object |
author |
SAYYAF DEZFULI, Bahram GIARI, Luisa Bosi, G Manera, M |
spellingShingle |
SAYYAF DEZFULI, Bahram GIARI, Luisa Bosi, G Manera, M Fish cells involved in mucosal immunity against enteric helminths. |
author_facet |
SAYYAF DEZFULI, Bahram GIARI, Luisa Bosi, G Manera, M |
author_sort |
SAYYAF DEZFULI, Bahram |
title |
Fish cells involved in mucosal immunity against enteric helminths. |
title_short |
Fish cells involved in mucosal immunity against enteric helminths. |
title_full |
Fish cells involved in mucosal immunity against enteric helminths. |
title_fullStr |
Fish cells involved in mucosal immunity against enteric helminths. |
title_full_unstemmed |
Fish cells involved in mucosal immunity against enteric helminths. |
title_sort |
fish cells involved in mucosal immunity against enteric helminths. |
publisher |
University of Valencia |
publishDate |
2015 |
url |
http://hdl.handle.net/11392/2330462 |
genre |
Anguilla anguilla |
genre_facet |
Anguilla anguilla |
op_relation |
ispartofbook:9th International Symposium on Fish Parasites. Book of abstracts 9th International Symposium on Fish Parasites firstpage:81 lastpage:81 numberofpages:1 http://hdl.handle.net/11392/2330462 |
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1790597414210502656 |