Geographic patterns of mt DNA diversity in Europe.
Genetic diversity in Europe has been interpreted as a reflection of phenomena occurring during the Paleolithic (»45,000 years before the present [BP]), Mesolithic (»18,000 years BP), and Neolithic (»10,000 years BP) periods. A crucial role of the Neolithic demographic transition is supported by the...
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ftunivferrarair:oai:iris.unife.it:11392/1197203 2024-02-11T10:08:18+01:00 Geographic patterns of mt DNA diversity in Europe. SIMONI L. CALAFELL F. PETTENER D. BERTRANPETIT J. BARBUJANI, Guido Simoni, L. Calafell, F. Pettener, D. Bertranpetit, J. Barbujani, Guido 2000 STAMPA http://hdl.handle.net/11392/1197203 eng eng volume:66 firstpage:262 lastpage:278 numberofpages:17 journal:AMERICAN JOURNAL OF HUMAN GENETICS http://hdl.handle.net/11392/1197203 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033940855 info:eu-repo/semantics/article 2000 ftunivferrarair 2024-01-24T17:34:14Z Genetic diversity in Europe has been interpreted as a reflection of phenomena occurring during the Paleolithic (»45,000 years before the present [BP]), Mesolithic (»18,000 years BP), and Neolithic (»10,000 years BP) periods. A crucial role of the Neolithic demographic transition is supported by the analysis of most nuclear loci, but the interpretation of mtDNA evidence is controversial. More than 2,600 sequences of the first hypervariable mitochondrial control region were analyzed for geographic patterns in samples from Europe, the Near East, and the Caucasus. Two autocorrelation statistics were used, one based on allele-frequency differences between samples and the other based on both sequence and frequency differences between alleles. In the global analysis, limited geographic patterning was observed, which could largely be attributed to a marked difference between the Saami and all other populations. The distribution of the zones of highest mitochondrial variation (genetic boundaries) confirmed that the Saami are sharply differentiated from an otherwise rather homogeneous set of European samples. However, an area of significant clinal variation was identified around the Mediterranean Sea (and not in the north), even though the differences between northern and southern populations were insignificant. Both a Paleolithic expansion and the Neolithic demic diffusion of farmers could have determined a longitudinal cline of mtDNA diversity. However, additional phenomena must be considered in both models, to account both for the north-south differences and for the greater geographic scope of clinal patterns at nuclear loci. Conversely, two predicted consequences of models of Mesolithic reexpansion from glacial refugia were not observed in the present study. Article in Journal/Newspaper saami Università degli Studi di Ferrara: CINECA IRIS |
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Università degli Studi di Ferrara: CINECA IRIS |
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ftunivferrarair |
language |
English |
description |
Genetic diversity in Europe has been interpreted as a reflection of phenomena occurring during the Paleolithic (»45,000 years before the present [BP]), Mesolithic (»18,000 years BP), and Neolithic (»10,000 years BP) periods. A crucial role of the Neolithic demographic transition is supported by the analysis of most nuclear loci, but the interpretation of mtDNA evidence is controversial. More than 2,600 sequences of the first hypervariable mitochondrial control region were analyzed for geographic patterns in samples from Europe, the Near East, and the Caucasus. Two autocorrelation statistics were used, one based on allele-frequency differences between samples and the other based on both sequence and frequency differences between alleles. In the global analysis, limited geographic patterning was observed, which could largely be attributed to a marked difference between the Saami and all other populations. The distribution of the zones of highest mitochondrial variation (genetic boundaries) confirmed that the Saami are sharply differentiated from an otherwise rather homogeneous set of European samples. However, an area of significant clinal variation was identified around the Mediterranean Sea (and not in the north), even though the differences between northern and southern populations were insignificant. Both a Paleolithic expansion and the Neolithic demic diffusion of farmers could have determined a longitudinal cline of mtDNA diversity. However, additional phenomena must be considered in both models, to account both for the north-south differences and for the greater geographic scope of clinal patterns at nuclear loci. Conversely, two predicted consequences of models of Mesolithic reexpansion from glacial refugia were not observed in the present study. |
author2 |
Simoni, L. Calafell, F. Pettener, D. Bertranpetit, J. Barbujani, Guido |
format |
Article in Journal/Newspaper |
author |
SIMONI L. CALAFELL F. PETTENER D. BERTRANPETIT J. BARBUJANI, Guido |
spellingShingle |
SIMONI L. CALAFELL F. PETTENER D. BERTRANPETIT J. BARBUJANI, Guido Geographic patterns of mt DNA diversity in Europe. |
author_facet |
SIMONI L. CALAFELL F. PETTENER D. BERTRANPETIT J. BARBUJANI, Guido |
author_sort |
SIMONI L. |
title |
Geographic patterns of mt DNA diversity in Europe. |
title_short |
Geographic patterns of mt DNA diversity in Europe. |
title_full |
Geographic patterns of mt DNA diversity in Europe. |
title_fullStr |
Geographic patterns of mt DNA diversity in Europe. |
title_full_unstemmed |
Geographic patterns of mt DNA diversity in Europe. |
title_sort |
geographic patterns of mt dna diversity in europe. |
publishDate |
2000 |
url |
http://hdl.handle.net/11392/1197203 |
genre |
saami |
genre_facet |
saami |
op_relation |
volume:66 firstpage:262 lastpage:278 numberofpages:17 journal:AMERICAN JOURNAL OF HUMAN GENETICS http://hdl.handle.net/11392/1197203 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033940855 |
_version_ |
1790607366786383872 |