Soybean glycinin (11S) increases HDL-cholesterol in hypercholesterolemic rats

• Published in: Nutrition & Food Science
• Main Authors: Fassini, Priscila Giácomo, de Souza Ferreira, Ederlan, da Silva, Maraiza Aparecida, Neves, Valdir Augusto, Demonte, Aureluce
• Other Authors: Universidade Estadual Paulista (UNESP)
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2012
• Subjects: Cholesterol; Diet; Experimental model; Hypercholesterolemia; Metabolism; Soybean glycinin; Animalia; Glycine max; Rattus; Rattus norvegicus; Rattus rattus
• Online Access: http://hdl.handle.net/11449/73205; https://doi.org/10.1108/00346651211212060

Purpose: The purpose of this paper is to determine the effects of isolated soy glycinin (11S) on lipid metabolism in animals subjected to a hypercholesterolemic diet. Design/methodology/approach: Male Wistar rats were kept in individual cages under appropriate conditions. The animals were divided into three groups (n=9): normal diet (STD) given a diet containing casein as protein source, recommended in AIN-93M; hypercholesterolemic (HC) fed a normal diet with 1 per cent cholesterol and 0.5 per cent cholic acid; and hypercholesterolemic+glycinin (HC+11S), fed a hypercholesterolemic diet, plus 11S soy protein (300 mg/kg/day), dissolved in saline and administered by gavage. After 28 days, the animals were sacrificed and blood and liver removed for biochemical analysis of total cholesterol (TC), HDL-cholesterol (HDL-C) and triglycerides (TG) in the plasma, hepatic TC and TG. Findings: A single daily dose of glycinin given to the hypercholesterolemic group demonstrated its functional role, particularly in raising HDL-C and reducing triglycerides in the liver. Originality/value: This study demonstrates the action of the 11S globulin in soybean as a serum lipid lowering agent, in addition to its nutritional properties, especially in raising the HDL-C. © Emerald Group Publishing Limited.