Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 2013/08248-1 and 2016/06931 CNPq: 407588/2013-2 Constant efforts to discover new ant...
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Online Access: | http://hdl.handle.net/11449/206408 https://doi.org/10.7324/JAPS.2020.101213 |
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ftunivespir:oai:repositorio.unesp.br:11449/206408 2023-07-02T03:30:08+02:00 Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent Clementino, Leandro Costa Torres, Fabio Aurelio Esteves Velasquez, Angela Maria Arenas Villela, Leonardo Mutue, Toyota Fujii Colepicolo, Pio Graminha, Marcia A.S. Universidade Estadual Paulista (UNESP) 2020-01-01 98-103 http://hdl.handle.net/11449/206408 https://doi.org/10.7324/JAPS.2020.101213 eng eng Journal of Applied Pharmaceutical Science http://dx.doi.org/10.7324/JAPS.2020.101213 Journal of Applied Pharmaceutical Science, v. 10, n. 12, p. 98-103, 2020. 2231-3354 http://hdl.handle.net/11449/206408 doi:10.7324/JAPS.2020.101213 2-s2.0-85106777961 13E-docosenamide antarctic macroalgae antileishmanial activity desmarestiaceae fatty acid info:eu-repo/semantics/article 2020 ftunivespir https://doi.org/10.7324/JAPS.2020.101213 2023-06-12T17:25:58Z Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 2013/08248-1 and 2016/06931 CNPq: 407588/2013-2 Constant efforts to discover new antileishmanial agents are important because there are only a few available drugs for the treatment of leishmaniasis, which present several drawbacks including high toxicity and difficult route of administration. In this scenario, different sources of natural products have been explored regarding their potential to treat infectious diseases. Following this initiative, our research team has been analyzing the bioactive potential of Himantothallus grandifolius, an endemic macroalga of the Antarctic region, with the hypothesis that the hostile environment imposed on these organisms has shaped its arsenal of chemical constituents, thus consequently bringing new opportunities to discover bioactive compounds that might be useful against leishmaniasis. Herein, we report the antileishmanial property of the fatty acid 13E-docosenamide, identified during the fractionation of the hexanic extract of H. grandifolius after semipreparative high performance liquid chromatography separation and ultrafast liquid chromatography coupled with mass spectrometry analyses to track its antileishmanial constituents. 13E-docosenamide was found in HSG11and HSG12 fractions, presented promising antileishmanial activity (IC50 = 9.6 μg ml-1) and is 10 times more selective to the parasite rather than to the host cells (SI > 10.4). Article in Journal/Newspaper Antarc* Antarctic Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP Antarctic The Antarctic Journal of Applied Pharmaceutical Science |
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Open Polar |
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Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP |
op_collection_id |
ftunivespir |
language |
English |
topic |
13E-docosenamide antarctic macroalgae antileishmanial activity desmarestiaceae fatty acid |
spellingShingle |
13E-docosenamide antarctic macroalgae antileishmanial activity desmarestiaceae fatty acid Clementino, Leandro Costa Torres, Fabio Aurelio Esteves Velasquez, Angela Maria Arenas Villela, Leonardo Mutue, Toyota Fujii Colepicolo, Pio Graminha, Marcia A.S. Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
topic_facet |
13E-docosenamide antarctic macroalgae antileishmanial activity desmarestiaceae fatty acid |
description |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 2013/08248-1 and 2016/06931 CNPq: 407588/2013-2 Constant efforts to discover new antileishmanial agents are important because there are only a few available drugs for the treatment of leishmaniasis, which present several drawbacks including high toxicity and difficult route of administration. In this scenario, different sources of natural products have been explored regarding their potential to treat infectious diseases. Following this initiative, our research team has been analyzing the bioactive potential of Himantothallus grandifolius, an endemic macroalga of the Antarctic region, with the hypothesis that the hostile environment imposed on these organisms has shaped its arsenal of chemical constituents, thus consequently bringing new opportunities to discover bioactive compounds that might be useful against leishmaniasis. Herein, we report the antileishmanial property of the fatty acid 13E-docosenamide, identified during the fractionation of the hexanic extract of H. grandifolius after semipreparative high performance liquid chromatography separation and ultrafast liquid chromatography coupled with mass spectrometry analyses to track its antileishmanial constituents. 13E-docosenamide was found in HSG11and HSG12 fractions, presented promising antileishmanial activity (IC50 = 9.6 μg ml-1) and is 10 times more selective to the parasite rather than to the host cells (SI > 10.4). |
author2 |
Universidade Estadual Paulista (UNESP) |
format |
Article in Journal/Newspaper |
author |
Clementino, Leandro Costa Torres, Fabio Aurelio Esteves Velasquez, Angela Maria Arenas Villela, Leonardo Mutue, Toyota Fujii Colepicolo, Pio Graminha, Marcia A.S. |
author_facet |
Clementino, Leandro Costa Torres, Fabio Aurelio Esteves Velasquez, Angela Maria Arenas Villela, Leonardo Mutue, Toyota Fujii Colepicolo, Pio Graminha, Marcia A.S. |
author_sort |
Clementino, Leandro Costa |
title |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title_short |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title_full |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title_fullStr |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title_full_unstemmed |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title_sort |
bioguided study of the antarctic alga himantothallus grandifolius (a. geep & e.s. geep) indicates 13e-docosenamide as potential antileishmanial agent |
publishDate |
2020 |
url |
http://hdl.handle.net/11449/206408 https://doi.org/10.7324/JAPS.2020.101213 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
Journal of Applied Pharmaceutical Science http://dx.doi.org/10.7324/JAPS.2020.101213 Journal of Applied Pharmaceutical Science, v. 10, n. 12, p. 98-103, 2020. 2231-3354 http://hdl.handle.net/11449/206408 doi:10.7324/JAPS.2020.101213 2-s2.0-85106777961 |
op_doi |
https://doi.org/10.7324/JAPS.2020.101213 |
container_title |
Journal of Applied Pharmaceutical Science |
_version_ |
1770274389743370240 |