Accuracy of genotype imputation and genomic predictions in a two-generation farmed Atlantic salmon population using high-density and low-density SNP panels
The objectives of this study were: (i) to assess genotype imputation accuracy in different scenarios using genome-wide single nucleotide polymorphisms (SNP) data from a population comprising two generations of farmed Atlantic salmon and (ii) to assess the accuracy of genomic predictions for a quanti...
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Online Access: | http://hdl.handle.net/11449/170787 https://doi.org/10.1016/j.aquaculture.2018.03.004 |
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ftunivespir:oai:repositorio.unesp.br:11449/170787 2023-07-02T03:31:42+02:00 Accuracy of genotype imputation and genomic predictions in a two-generation farmed Atlantic salmon population using high-density and low-density SNP panels Yoshida, Grazyella M. Carvalheiro, Roberto Lhorente, Jean P. Correa, Katharina Figueroa, René Houston, Ross D. Yáñez, José M. Universidade Estadual Paulista (UNESP) 2018-04-01 147-154 http://hdl.handle.net/11449/170787 https://doi.org/10.1016/j.aquaculture.2018.03.004 eng eng Aquaculture 1,152 http://dx.doi.org/10.1016/j.aquaculture.2018.03.004 Aquaculture, v. 491, p. 147-154. 0044-8486 http://hdl.handle.net/11449/170787 doi:10.1016/j.aquaculture.2018.03.004 2-s2.0-85044099550 2-s2.0-85044099550.pdf openAccess Cost-effectiveness Genome-wide association studies Genomic selection Salmo salar Single nucleotide polymorphism info:eu-repo/semantics/article 2018 ftunivespir https://doi.org/10.1016/j.aquaculture.2018.03.004 2023-06-12T17:05:42Z The objectives of this study were: (i) to assess genotype imputation accuracy in different scenarios using genome-wide single nucleotide polymorphisms (SNP) data from a population comprising two generations of farmed Atlantic salmon and (ii) to assess the accuracy of genomic predictions for a quantitative trait (body weight) using the imputed genotypes. The pedigree consisted of 53 parents and 1069 offspring genotyped using a high-density SNP panel (50 K). Two groups were created: Group A: 90% of the offspring were included into training and 10% into validation sets; Group B: 10% of the offspring were included into training and 90% into validation sets. Different scenarios of available genotypic information from relatives were tested for the two groups previously described. Imputation was performed using three in silico low-density panels (0.5, 3 and 6 K) with all markers except the markers present on the low-density panel masked in the validation sets. The accuracy of genomic selection was tested using the scenarios that resulted in the best and the worst imputation accuracy for the three low density panels and were compared to accuracy obtained from pedigree-based best linear unbiased prediction (PBLUP) and genomic predictions using the 50 K SNP panel. In general, imputation accuracy ranged from 0.74 to 0.98 depending on scenario. For the best scenario with the highest number of animals in reference population (Group A), the accuracy of imputation ranged from 0.95 to 0.98 depending on the low-density panel used. For the best scenario with the lowest number of animals in reference population (Group B), the accuracy of imputation ranged from 0.94 to 0.98 depending on the low-density panel used. In general, the number of SNPs in the low-density panels had a greater influence on the accuracy of imputation than the size of the reference set. The accuracies of genomic predictions using imputed genotypes, ranging from 0.71 to 0.73, outperformed PBLUP (0.66) and were identical or very similar to the use of all true ... Article in Journal/Newspaper Atlantic salmon Salmo salar Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP Aquaculture 491 147 154 |
institution |
Open Polar |
collection |
Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP |
op_collection_id |
ftunivespir |
language |
English |
topic |
Cost-effectiveness Genome-wide association studies Genomic selection Salmo salar Single nucleotide polymorphism |
spellingShingle |
Cost-effectiveness Genome-wide association studies Genomic selection Salmo salar Single nucleotide polymorphism Yoshida, Grazyella M. Carvalheiro, Roberto Lhorente, Jean P. Correa, Katharina Figueroa, René Houston, Ross D. Yáñez, José M. Accuracy of genotype imputation and genomic predictions in a two-generation farmed Atlantic salmon population using high-density and low-density SNP panels |
topic_facet |
Cost-effectiveness Genome-wide association studies Genomic selection Salmo salar Single nucleotide polymorphism |
description |
The objectives of this study were: (i) to assess genotype imputation accuracy in different scenarios using genome-wide single nucleotide polymorphisms (SNP) data from a population comprising two generations of farmed Atlantic salmon and (ii) to assess the accuracy of genomic predictions for a quantitative trait (body weight) using the imputed genotypes. The pedigree consisted of 53 parents and 1069 offspring genotyped using a high-density SNP panel (50 K). Two groups were created: Group A: 90% of the offspring were included into training and 10% into validation sets; Group B: 10% of the offspring were included into training and 90% into validation sets. Different scenarios of available genotypic information from relatives were tested for the two groups previously described. Imputation was performed using three in silico low-density panels (0.5, 3 and 6 K) with all markers except the markers present on the low-density panel masked in the validation sets. The accuracy of genomic selection was tested using the scenarios that resulted in the best and the worst imputation accuracy for the three low density panels and were compared to accuracy obtained from pedigree-based best linear unbiased prediction (PBLUP) and genomic predictions using the 50 K SNP panel. In general, imputation accuracy ranged from 0.74 to 0.98 depending on scenario. For the best scenario with the highest number of animals in reference population (Group A), the accuracy of imputation ranged from 0.95 to 0.98 depending on the low-density panel used. For the best scenario with the lowest number of animals in reference population (Group B), the accuracy of imputation ranged from 0.94 to 0.98 depending on the low-density panel used. In general, the number of SNPs in the low-density panels had a greater influence on the accuracy of imputation than the size of the reference set. The accuracies of genomic predictions using imputed genotypes, ranging from 0.71 to 0.73, outperformed PBLUP (0.66) and were identical or very similar to the use of all true ... |
author2 |
Universidade Estadual Paulista (UNESP) |
format |
Article in Journal/Newspaper |
author |
Yoshida, Grazyella M. Carvalheiro, Roberto Lhorente, Jean P. Correa, Katharina Figueroa, René Houston, Ross D. Yáñez, José M. |
author_facet |
Yoshida, Grazyella M. Carvalheiro, Roberto Lhorente, Jean P. Correa, Katharina Figueroa, René Houston, Ross D. Yáñez, José M. |
author_sort |
Yoshida, Grazyella M. |
title |
Accuracy of genotype imputation and genomic predictions in a two-generation farmed Atlantic salmon population using high-density and low-density SNP panels |
title_short |
Accuracy of genotype imputation and genomic predictions in a two-generation farmed Atlantic salmon population using high-density and low-density SNP panels |
title_full |
Accuracy of genotype imputation and genomic predictions in a two-generation farmed Atlantic salmon population using high-density and low-density SNP panels |
title_fullStr |
Accuracy of genotype imputation and genomic predictions in a two-generation farmed Atlantic salmon population using high-density and low-density SNP panels |
title_full_unstemmed |
Accuracy of genotype imputation and genomic predictions in a two-generation farmed Atlantic salmon population using high-density and low-density SNP panels |
title_sort |
accuracy of genotype imputation and genomic predictions in a two-generation farmed atlantic salmon population using high-density and low-density snp panels |
publishDate |
2018 |
url |
http://hdl.handle.net/11449/170787 https://doi.org/10.1016/j.aquaculture.2018.03.004 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
Aquaculture 1,152 http://dx.doi.org/10.1016/j.aquaculture.2018.03.004 Aquaculture, v. 491, p. 147-154. 0044-8486 http://hdl.handle.net/11449/170787 doi:10.1016/j.aquaculture.2018.03.004 2-s2.0-85044099550 2-s2.0-85044099550.pdf |
op_rights |
openAccess |
op_doi |
https://doi.org/10.1016/j.aquaculture.2018.03.004 |
container_title |
Aquaculture |
container_volume |
491 |
container_start_page |
147 |
op_container_end_page |
154 |
_version_ |
1770271097917276160 |