Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats
This work has evaluated the hematological and biochemical profile by the use of sodium diclofenac, meloxicam and firocoxib in Wistar rats. The rats were distributed in groups: G1 (control), G2 (diclofenac sodium: 15 mg/kg), G3 (meloxicam: 2.0 mg/ kg), G4 (meloxicam: 10.0 mg/ kg), G5 (firocoxib: 5.0...
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Online Access: | http://acervodigital.unesp.br/handle/11449/72185 http://hdl.handle.net/11449/72185 http://www.revistas.usp.br/bjvras/article/view/26835 |
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ftunivesp:oai:acervodigital.unesp.br:11449/72185 2023-05-15T18:05:27+02:00 Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats Barbosa, Cristiane Moraes Sakate, Michiko Camplesi, Annelise Carla Vailati, Maria do Carmo Fernandez Moraes, Lívia Fagundes Takahira, Regina Kiomi Universidade Estadual Paulista (UNESP) 2014-05-27T11:25:24Z http://acervodigital.unesp.br/handle/11449/72185 http://hdl.handle.net/11449/72185 http://www.revistas.usp.br/bjvras/article/view/26835 fra fre Brazilian Journal of Veterinary Research and Animal Science Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 2, p. 118-126, 2010. 1413-9596 1678-4456 http://hdl.handle.net/11449/72185 http://acervodigital.unesp.br/handle/11449/72185 2-s2.0-78649408124.pdf 2-s2.0-78649408124 orcid:0000-0003-3323-4199 http://www.revistas.usp.br/bjvras/article/view/26835 info:eu-repo/semantics/openAccess Firocoxib Laboratories parameters Meloxicam Rats Sodium diclofenac Animalia Rattus Rattus norvegicus outro 2014 ftunivesp 2021-07-18T08:41:41Z This work has evaluated the hematological and biochemical profile by the use of sodium diclofenac, meloxicam and firocoxib in Wistar rats. The rats were distributed in groups: G1 (control), G2 (diclofenac sodium: 15 mg/kg), G3 (meloxicam: 2.0 mg/ kg), G4 (meloxicam: 10.0 mg/ kg), G5 (firocoxib: 5.0 mg/ kg) e G6 (firocoxib: 25.0 mg/ kg). The drugs were administered intragastrically (gavage) once a day, during five days and evaluated in three moments: M1 (48 hours after the beginning of the treatment), M2 (96 hours after the beginning of the treatment) and M3 (72 hours after the ending of the treatment). In each moment of each group, five to seven animals were evaluated and laboratory exams were performed. There were no significant changes observed in the biochemical and hematological parameters by the use of meloxicam and firocoxib. One of the effects of the sodium diclofenac was eritrogram variation as hematocrit, erythrocytes, hemoglobin decrease during the treatment. In addition, the platelets and total white blood cells counts did not change except for basophil. There was no changes in AST, ALP, GGT, urea, creatinine, sodium, potassium values. However, the values of protein, globulin and albumin decreased. It was concluded that diclofenac sodium does not provide large variations in the hemogram and biochemical profile than the meloxicam and firocoxib do not provide delletery effects in laboratories tests. Other/Unknown Material Rattus rattus Universidade Estadual Paulista São Paulo: Acervo Digital da UNESP / São Paulo State University |
institution |
Open Polar |
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Universidade Estadual Paulista São Paulo: Acervo Digital da UNESP / São Paulo State University |
op_collection_id |
ftunivesp |
language |
French |
topic |
Firocoxib Laboratories parameters Meloxicam Rats Sodium diclofenac Animalia Rattus Rattus norvegicus |
spellingShingle |
Firocoxib Laboratories parameters Meloxicam Rats Sodium diclofenac Animalia Rattus Rattus norvegicus Barbosa, Cristiane Moraes Sakate, Michiko Camplesi, Annelise Carla Vailati, Maria do Carmo Fernandez Moraes, Lívia Fagundes Takahira, Regina Kiomi Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
topic_facet |
Firocoxib Laboratories parameters Meloxicam Rats Sodium diclofenac Animalia Rattus Rattus norvegicus |
description |
This work has evaluated the hematological and biochemical profile by the use of sodium diclofenac, meloxicam and firocoxib in Wistar rats. The rats were distributed in groups: G1 (control), G2 (diclofenac sodium: 15 mg/kg), G3 (meloxicam: 2.0 mg/ kg), G4 (meloxicam: 10.0 mg/ kg), G5 (firocoxib: 5.0 mg/ kg) e G6 (firocoxib: 25.0 mg/ kg). The drugs were administered intragastrically (gavage) once a day, during five days and evaluated in three moments: M1 (48 hours after the beginning of the treatment), M2 (96 hours after the beginning of the treatment) and M3 (72 hours after the ending of the treatment). In each moment of each group, five to seven animals were evaluated and laboratory exams were performed. There were no significant changes observed in the biochemical and hematological parameters by the use of meloxicam and firocoxib. One of the effects of the sodium diclofenac was eritrogram variation as hematocrit, erythrocytes, hemoglobin decrease during the treatment. In addition, the platelets and total white blood cells counts did not change except for basophil. There was no changes in AST, ALP, GGT, urea, creatinine, sodium, potassium values. However, the values of protein, globulin and albumin decreased. It was concluded that diclofenac sodium does not provide large variations in the hemogram and biochemical profile than the meloxicam and firocoxib do not provide delletery effects in laboratories tests. |
author2 |
Universidade Estadual Paulista (UNESP) |
format |
Other/Unknown Material |
author |
Barbosa, Cristiane Moraes Sakate, Michiko Camplesi, Annelise Carla Vailati, Maria do Carmo Fernandez Moraes, Lívia Fagundes Takahira, Regina Kiomi |
author_facet |
Barbosa, Cristiane Moraes Sakate, Michiko Camplesi, Annelise Carla Vailati, Maria do Carmo Fernandez Moraes, Lívia Fagundes Takahira, Regina Kiomi |
author_sort |
Barbosa, Cristiane Moraes |
title |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
title_short |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
title_full |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
title_fullStr |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
title_full_unstemmed |
Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
title_sort |
evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats |
publishDate |
2014 |
url |
http://acervodigital.unesp.br/handle/11449/72185 http://hdl.handle.net/11449/72185 http://www.revistas.usp.br/bjvras/article/view/26835 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
Brazilian Journal of Veterinary Research and Animal Science Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 2, p. 118-126, 2010. 1413-9596 1678-4456 http://hdl.handle.net/11449/72185 http://acervodigital.unesp.br/handle/11449/72185 2-s2.0-78649408124.pdf 2-s2.0-78649408124 orcid:0000-0003-3323-4199 http://www.revistas.usp.br/bjvras/article/view/26835 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1766176919954391040 |