Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols
In search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion. First, two adult rat groups (aged 90 d) were studied: a control group (C1; n 6) received regular rodent...
Published in: | British Journal of Nutrition |
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Online Access: | http://acervodigital.unesp.br/handle/11449/71087 http://hdl.handle.net/11449/71087 https://doi.org/10.1017/S0007114508066774 |
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ftunivesp:oai:acervodigital.unesp.br:11449/71087 2023-05-15T18:05:43+02:00 Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols de Moura, Rodrigo Ferreira Ribeiro, Carla de Oliveira, Juliana Aparecida Stevanato, Eliane de Mello, Maria Alice Rostom Universidade Estadual Paulista (UNESP) 2014-05-27T11:23:56Z http://acervodigital.unesp.br/handle/11449/71087 http://hdl.handle.net/11449/71087 https://doi.org/10.1017/S0007114508066774 eng eng British Journal of Nutrition British Journal of Nutrition, v. 101, n. 8, p. 1178-1184, 2009. 0007-1145 1475-2662 http://hdl.handle.net/11449/71087 http://acervodigital.unesp.br/handle/11449/71087 doi:10.1017/S0007114508066774 2-s2.0-67649429383.pdf 2-s2.0-67649429383 http://dx.doi.org/10.1017/S0007114508066774 info:eu-repo/semantics/closedAccess Body fat Fructose Insulin sensitivity Metabolic syndrome cholesterol drinking water high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol age distribution animal experiment animal model carbohydrate intake cholesterol blood level controlled study experimental rat food analysis food composition fructose metabolism glucose tolerance hypertriglyceridemia lipid blood level male metabolic balance metabolic syndrome X nonhuman rat triacylglycerol blood level Wistar rat Animals Blood Glucose Disease Models Animal Glucose Tolerance Test Insulin Insulin Resistance Rats Wistar Weight Gain Animalia Rattus Rattus norvegicus Rodentia outro 2014 ftunivesp https://doi.org/10.1017/S0007114508066774 2021-07-18T08:41:10Z In search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion. First, two adult rat groups (aged 90 d) were studied: a control group (C1; n 6) received regular rodent chow (Labina, Purina) and a fructose group (F1; n 6) was fed on regular rodent chow. Fructose was administered as a 10 % solution in drinking water. Second, two adult rat groups (aged 90 d) were evaluated: a control group (C2; n 6) was fed on a balanced diet (AIN-93G) and a fructose group (F2; n 6) was fed on a purified 60 % fructose diet. Finally, two young rat groups (aged 28 d) were analysed: a control group (C3; n 6) was fed on the AIN-93G diet and a fructose group (F3; n 6) was fed on a 60 % fructose diet. After 4-8 weeks, the animals were evaluated. Glucose tolerance, peripheral insulin sensitivity, blood lipid profile and body fat were analysed. In the fructose groups F2 and F3 glucose tolerance and insulin sensitivity were lower, while triacylglycerolaemia was higher than the respective controls C2 and C3 (P < 0.05). Blood total cholesterol, HDL and LDL as well as body fat showed change only in the second protocol. In conclusion, high fructose intake is more effective at producing the signs of the metabolic syndrome in adult than in young Wistar rats. Additionally, diet seems to be a more effective way of fructose administration than drinking water. Other/Unknown Material Rattus rattus Universidade Estadual Paulista São Paulo: Acervo Digital da UNESP / São Paulo State University British Journal of Nutrition 101 8 1178 1184 |
institution |
Open Polar |
collection |
Universidade Estadual Paulista São Paulo: Acervo Digital da UNESP / São Paulo State University |
op_collection_id |
ftunivesp |
language |
English |
topic |
Body fat Fructose Insulin sensitivity Metabolic syndrome cholesterol drinking water high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol age distribution animal experiment animal model carbohydrate intake cholesterol blood level controlled study experimental rat food analysis food composition fructose metabolism glucose tolerance hypertriglyceridemia lipid blood level male metabolic balance metabolic syndrome X nonhuman rat triacylglycerol blood level Wistar rat Animals Blood Glucose Disease Models Animal Glucose Tolerance Test Insulin Insulin Resistance Rats Wistar Weight Gain Animalia Rattus Rattus norvegicus Rodentia |
spellingShingle |
Body fat Fructose Insulin sensitivity Metabolic syndrome cholesterol drinking water high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol age distribution animal experiment animal model carbohydrate intake cholesterol blood level controlled study experimental rat food analysis food composition fructose metabolism glucose tolerance hypertriglyceridemia lipid blood level male metabolic balance metabolic syndrome X nonhuman rat triacylglycerol blood level Wistar rat Animals Blood Glucose Disease Models Animal Glucose Tolerance Test Insulin Insulin Resistance Rats Wistar Weight Gain Animalia Rattus Rattus norvegicus Rodentia de Moura, Rodrigo Ferreira Ribeiro, Carla de Oliveira, Juliana Aparecida Stevanato, Eliane de Mello, Maria Alice Rostom Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols |
topic_facet |
Body fat Fructose Insulin sensitivity Metabolic syndrome cholesterol drinking water high density lipoprotein cholesterol lipid low density lipoprotein cholesterol triacylglycerol age distribution animal experiment animal model carbohydrate intake cholesterol blood level controlled study experimental rat food analysis food composition fructose metabolism glucose tolerance hypertriglyceridemia lipid blood level male metabolic balance metabolic syndrome X nonhuman rat triacylglycerol blood level Wistar rat Animals Blood Glucose Disease Models Animal Glucose Tolerance Test Insulin Insulin Resistance Rats Wistar Weight Gain Animalia Rattus Rattus norvegicus Rodentia |
description |
In search of an adequate model for the human metabolic syndrome, the metabolic characteristics of Wistar rats were analysed after being submitted to different protocols of high fructose ingestion. First, two adult rat groups (aged 90 d) were studied: a control group (C1; n 6) received regular rodent chow (Labina, Purina) and a fructose group (F1; n 6) was fed on regular rodent chow. Fructose was administered as a 10 % solution in drinking water. Second, two adult rat groups (aged 90 d) were evaluated: a control group (C2; n 6) was fed on a balanced diet (AIN-93G) and a fructose group (F2; n 6) was fed on a purified 60 % fructose diet. Finally, two young rat groups (aged 28 d) were analysed: a control group (C3; n 6) was fed on the AIN-93G diet and a fructose group (F3; n 6) was fed on a 60 % fructose diet. After 4-8 weeks, the animals were evaluated. Glucose tolerance, peripheral insulin sensitivity, blood lipid profile and body fat were analysed. In the fructose groups F2 and F3 glucose tolerance and insulin sensitivity were lower, while triacylglycerolaemia was higher than the respective controls C2 and C3 (P < 0.05). Blood total cholesterol, HDL and LDL as well as body fat showed change only in the second protocol. In conclusion, high fructose intake is more effective at producing the signs of the metabolic syndrome in adult than in young Wistar rats. Additionally, diet seems to be a more effective way of fructose administration than drinking water. |
author2 |
Universidade Estadual Paulista (UNESP) |
format |
Other/Unknown Material |
author |
de Moura, Rodrigo Ferreira Ribeiro, Carla de Oliveira, Juliana Aparecida Stevanato, Eliane de Mello, Maria Alice Rostom |
author_facet |
de Moura, Rodrigo Ferreira Ribeiro, Carla de Oliveira, Juliana Aparecida Stevanato, Eliane de Mello, Maria Alice Rostom |
author_sort |
de Moura, Rodrigo Ferreira |
title |
Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols |
title_short |
Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols |
title_full |
Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols |
title_fullStr |
Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols |
title_full_unstemmed |
Metabolic syndrome signs in Wistar rats submitted to different high-fructose ingestion protocols |
title_sort |
metabolic syndrome signs in wistar rats submitted to different high-fructose ingestion protocols |
publishDate |
2014 |
url |
http://acervodigital.unesp.br/handle/11449/71087 http://hdl.handle.net/11449/71087 https://doi.org/10.1017/S0007114508066774 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
British Journal of Nutrition British Journal of Nutrition, v. 101, n. 8, p. 1178-1184, 2009. 0007-1145 1475-2662 http://hdl.handle.net/11449/71087 http://acervodigital.unesp.br/handle/11449/71087 doi:10.1017/S0007114508066774 2-s2.0-67649429383.pdf 2-s2.0-67649429383 http://dx.doi.org/10.1017/S0007114508066774 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1017/S0007114508066774 |
container_title |
British Journal of Nutrition |
container_volume |
101 |
container_issue |
8 |
container_start_page |
1178 |
op_container_end_page |
1184 |
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1766177216206471168 |