Efeito hipotensor do extrato aquoso de alpiste (Phalaris canariensis L.) em ratos

The plant species Phalaris canariensis, known as canary grass, is widely used in folk medicine as diuretic, as well as in culinary and animal feed. In this study, the effect of P. canariensis aqueous extract (AE) on water flow (V) and sodium renal excretion (Qe (Na+)) was evaluated in anesthetized W...

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Bibliographic Details
Main Authors: Balbi, A. P C, Campos, K. E., Alves, M. J Q F
Other Authors: Universidade Estadual Paulista (UNESP)
Format: Other/Unknown Material
Language:Portuguese
Published: 2014
Subjects:
Arterial pressure
Canary grass
Phalaris canariensis
Wistar rat
antihypertensive agent
Phalaris canariensis extract
plant extract
unclassified drug
animal experiment
antihypertensive activity
cannulation
carotid artery
controlled study
male
nonhuman
Phalaris
rat
sodium excretion
urinary excretion
water flow
Animalia
Phalaris aquatica
Rattus
Rattus norvegicus
Rattus rattus
Online Access:http://acervodigital.unesp.br/handle/11449/70795
http://hdl.handle.net/11449/70795
http://www.ibb.unesp.br/Home/Departamentos/Botanica/RBPM-RevistaBrasileiradePlantasMedicinais/artigo9_v10n3.pdf
Description
Summary:The plant species Phalaris canariensis, known as canary grass, is widely used in folk medicine as diuretic, as well as in culinary and animal feed. In this study, the effect of P. canariensis aqueous extract (AE) on water flow (V) and sodium renal excretion (Qe (Na+)) was evaluated in anesthetized Wistar rats. Arterial pressure alterations (AP) were also assessed. Two groups were studied: Control group (CON) - oral administration of 1.0 mL distilled water, and Experimental group (EA) - oral administration of 1.0 mL P. canariensis aqueous extract 40%. Rats were anesthetized and subjected to cannulation of trachea (for better pulmonary ventilation), left carotid artery (for arterial pressure measurement) and urinary bladder (for urine collection). Control animals did not present significant alterations (p>0.05) in all analyzed parameters after water administration. EA group had a significant arterial pressure reduction at 60 minutes (31.4%) and 90 minutes (49.1%) after the extract administration (p<0.05). Renal parameters did not have any significant alteration (p>0.05). In this study, P. canariensis aqueous extract had a hypotensive effect in anesthetized Wistar rats, without renal alterations.

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