Effects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein
Fertility in female mammals may be affected by a variety of endocrine disrupters present in the environment. Herbicide atrazine is an example of endocrine disrupter employed in agriculture, which disrupts estrous cyclicity in rats. Aiming to characterize morphologically the effect of low and subleth...
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Online Access: | http://acervodigital.unesp.br/handle/11449/70448 http://hdl.handle.net/11449/70448 https://doi.org/10.1016/j.micron.2007.04.006 |
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ftunivesp:oai:acervodigital.unesp.br:11449/70448 2023-05-15T18:05:32+02:00 Effects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein Juliani, C. C. Silva-Zacarin, E. C M Santos, D. C. Boer, P. A. Universidade Estadual Paulista (UNESP) 2014-05-27T11:23:35Z http://acervodigital.unesp.br/handle/11449/70448 http://hdl.handle.net/11449/70448 https://doi.org/10.1016/j.micron.2007.04.006 eng eng Micron Micron, v. 39, n. 5, p. 607-616, 2008. 0968-4328 http://hdl.handle.net/11449/70448 http://acervodigital.unesp.br/handle/11449/70448 doi:10.1016/j.micron.2007.04.006 2-s2.0-44949197583 http://dx.doi.org/10.1016/j.micron.2007.04.006 info:eu-repo/semantics/closedAccess Cell death Chaperone Environmental toxicology Fertility Folliculogenesis Granulosa cell Oocyte Agricultural engineering Biodiversity Endocrinology Labeling Mammals Pest control Photoacoustic effect Pigments Plasmas Proteins Rats Weed control (abiotic and biotic) stress (I ,J) conditions adult females Atrazine (ATR) Cyclicity Elsevier (CO) Endocrine disrupters Female Wistar rats Heat shock protein (Hsp) Herbicide exposure Immunocytochemical In order low dose Ovarian follicles Reproductive capacity Subchronic Sublethal doses Wistar rats Herbicides atrazine heat shock protein 90 herbicide animal drug effect female immunohistochemistry metabolism methodology ovary ovary follicle ovary follicle atresia physiology rat ultrastructure Wistar rat Animals Follicular Atresia HSP90 Heat-Shock Proteins Ovarian Follicle Wistar Mammalia Rattus Rattus norvegicus outro 2014 ftunivesp https://doi.org/10.1016/j.micron.2007.04.006 2021-07-18T08:40:52Z Fertility in female mammals may be affected by a variety of endocrine disrupters present in the environment. Herbicide atrazine is an example of endocrine disrupter employed in agriculture, which disrupts estrous cyclicity in rats. Aiming to characterize morphologically the effect of low and sublethal doses of atrazine on the ovaries of Wistar rats, in an effort to determine the possible intrafollicular target site through which this herbicide acts adult females were submitted to both subacute and subchronic treatments. Additionally, immunocytochemical labeling of 90 kDa heat shock protein (HSP90) was performed in order to evaluate the role played by this protein in the ovary, under stressed conditions induced by herbicide exposure. The results indicated that atrazine induced impaired folliculogenesis, increased follicular atresia and HSP90 depletion in female rats submitted to subacute treatment, while the subchronic treatment with low dose of atrazine could compromise the reproductive capacity reflected by the presence of multioocytic follicle and stress-inducible HSP90. © 2007 Elsevier Ltd. All rights reserved. Other/Unknown Material Rattus rattus Universidade Estadual Paulista São Paulo: Acervo Digital da UNESP / São Paulo State University Micron 39 5 607 616 |
institution |
Open Polar |
collection |
Universidade Estadual Paulista São Paulo: Acervo Digital da UNESP / São Paulo State University |
op_collection_id |
ftunivesp |
language |
English |
topic |
Cell death Chaperone Environmental toxicology Fertility Folliculogenesis Granulosa cell Oocyte Agricultural engineering Biodiversity Endocrinology Labeling Mammals Pest control Photoacoustic effect Pigments Plasmas Proteins Rats Weed control (abiotic and biotic) stress (I ,J) conditions adult females Atrazine (ATR) Cyclicity Elsevier (CO) Endocrine disrupters Female Wistar rats Heat shock protein (Hsp) Herbicide exposure Immunocytochemical In order low dose Ovarian follicles Reproductive capacity Subchronic Sublethal doses Wistar rats Herbicides atrazine heat shock protein 90 herbicide animal drug effect female immunohistochemistry metabolism methodology ovary ovary follicle ovary follicle atresia physiology rat ultrastructure Wistar rat Animals Follicular Atresia HSP90 Heat-Shock Proteins Ovarian Follicle Wistar Mammalia Rattus Rattus norvegicus |
spellingShingle |
Cell death Chaperone Environmental toxicology Fertility Folliculogenesis Granulosa cell Oocyte Agricultural engineering Biodiversity Endocrinology Labeling Mammals Pest control Photoacoustic effect Pigments Plasmas Proteins Rats Weed control (abiotic and biotic) stress (I ,J) conditions adult females Atrazine (ATR) Cyclicity Elsevier (CO) Endocrine disrupters Female Wistar rats Heat shock protein (Hsp) Herbicide exposure Immunocytochemical In order low dose Ovarian follicles Reproductive capacity Subchronic Sublethal doses Wistar rats Herbicides atrazine heat shock protein 90 herbicide animal drug effect female immunohistochemistry metabolism methodology ovary ovary follicle ovary follicle atresia physiology rat ultrastructure Wistar rat Animals Follicular Atresia HSP90 Heat-Shock Proteins Ovarian Follicle Wistar Mammalia Rattus Rattus norvegicus Juliani, C. C. Silva-Zacarin, E. C M Santos, D. C. Boer, P. A. Effects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein |
topic_facet |
Cell death Chaperone Environmental toxicology Fertility Folliculogenesis Granulosa cell Oocyte Agricultural engineering Biodiversity Endocrinology Labeling Mammals Pest control Photoacoustic effect Pigments Plasmas Proteins Rats Weed control (abiotic and biotic) stress (I ,J) conditions adult females Atrazine (ATR) Cyclicity Elsevier (CO) Endocrine disrupters Female Wistar rats Heat shock protein (Hsp) Herbicide exposure Immunocytochemical In order low dose Ovarian follicles Reproductive capacity Subchronic Sublethal doses Wistar rats Herbicides atrazine heat shock protein 90 herbicide animal drug effect female immunohistochemistry metabolism methodology ovary ovary follicle ovary follicle atresia physiology rat ultrastructure Wistar rat Animals Follicular Atresia HSP90 Heat-Shock Proteins Ovarian Follicle Wistar Mammalia Rattus Rattus norvegicus |
description |
Fertility in female mammals may be affected by a variety of endocrine disrupters present in the environment. Herbicide atrazine is an example of endocrine disrupter employed in agriculture, which disrupts estrous cyclicity in rats. Aiming to characterize morphologically the effect of low and sublethal doses of atrazine on the ovaries of Wistar rats, in an effort to determine the possible intrafollicular target site through which this herbicide acts adult females were submitted to both subacute and subchronic treatments. Additionally, immunocytochemical labeling of 90 kDa heat shock protein (HSP90) was performed in order to evaluate the role played by this protein in the ovary, under stressed conditions induced by herbicide exposure. The results indicated that atrazine induced impaired folliculogenesis, increased follicular atresia and HSP90 depletion in female rats submitted to subacute treatment, while the subchronic treatment with low dose of atrazine could compromise the reproductive capacity reflected by the presence of multioocytic follicle and stress-inducible HSP90. © 2007 Elsevier Ltd. All rights reserved. |
author2 |
Universidade Estadual Paulista (UNESP) |
format |
Other/Unknown Material |
author |
Juliani, C. C. Silva-Zacarin, E. C M Santos, D. C. Boer, P. A. |
author_facet |
Juliani, C. C. Silva-Zacarin, E. C M Santos, D. C. Boer, P. A. |
author_sort |
Juliani, C. C. |
title |
Effects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein |
title_short |
Effects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein |
title_full |
Effects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein |
title_fullStr |
Effects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein |
title_full_unstemmed |
Effects of atrazine on female Wistar rats: Morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kDa heat shock protein |
title_sort |
effects of atrazine on female wistar rats: morphological alterations in ovarian follicles and immunocytochemical labeling of 90 kda heat shock protein |
publishDate |
2014 |
url |
http://acervodigital.unesp.br/handle/11449/70448 http://hdl.handle.net/11449/70448 https://doi.org/10.1016/j.micron.2007.04.006 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
Micron Micron, v. 39, n. 5, p. 607-616, 2008. 0968-4328 http://hdl.handle.net/11449/70448 http://acervodigital.unesp.br/handle/11449/70448 doi:10.1016/j.micron.2007.04.006 2-s2.0-44949197583 http://dx.doi.org/10.1016/j.micron.2007.04.006 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.micron.2007.04.006 |
container_title |
Micron |
container_volume |
39 |
container_issue |
5 |
container_start_page |
607 |
op_container_end_page |
616 |
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1766177023241224192 |