Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays
Casearia sylvestris (Flacourtiaceae) is a plant which grows in wild and has been widely used in folk medicine. In this study, clastogenic/aneugenic properties of Casearia sylvestris crude ethanolic extract were evaluated using in vivo chromosomal aberrations (CAs) and micronucleus (MN) assays in rod...
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2014
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ftunivesp:oai:acervodigital.unesp.br:11449/70044 2023-05-15T18:05:19+02:00 Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays Maistro, Edson Luis De Andrade, Sergio Faloni Puras, Marilane Aparecida Universidade Estadual Paulista (UNESP) 2014-05-27T11:22:40Z http://acervodigital.unesp.br/handle/11449/70044 http://hdl.handle.net/11449/70044 https://doi.org/10.1508/cytologia.72.401 eng eng Cytologia Cytologia, v. 72, n. 4, p. 401-407, 2007. 0011-4545 http://hdl.handle.net/11449/70044 http://acervodigital.unesp.br/handle/11449/70044 doi:10.1508/cytologia.72.401 2-s2.0-39349107050.pdf 2-s2.0-39349107050 http://dx.doi.org/10.1508/cytologia.72.401 info:eu-repo/semantics/openAccess Casearia sylvestris Chromosome aberration In vivo Micronucleus test Animalia Casearia Flacourtiaceae Mus Rattus Rattus norvegicus Rodentia outro 2014 ftunivesp https://doi.org/10.1508/cytologia.72.401 2021-07-18T08:40:39Z Casearia sylvestris (Flacourtiaceae) is a plant which grows in wild and has been widely used in folk medicine. In this study, clastogenic/aneugenic properties of Casearia sylvestris crude ethanolic extract were evaluated using in vivo chromosomal aberrations (CAs) and micronucleus (MN) assays in rodents. The animals were treated by gavage with 3 concentrations of the extract: 150, 300 and 500 mg/kg body weight. Bone marrow cells from Wistar rats were collected 24 h after having been submitted to the MN and CAs test. Peripheral blood cells from Swiss mice were collected 48 and 72 h after having been submitted to the MN test. The results show that C. sylvestris extract does not induce a significant increase in mean values for micronucleated polychromatic erythrocytes (MNPCE) in Swiss mice and Wistar rats, or CAs in rat bone marrow cells, at the 3 tested doses, indicating that the extract showed no clastogenic/aneugenic effects on chromosomes of the rodent cells tested. © 2007 The Japan Mendel Society. Other/Unknown Material Rattus rattus Universidade Estadual Paulista São Paulo: Acervo Digital da UNESP / São Paulo State University CYTOLOGIA 72 4 401 407 |
institution |
Open Polar |
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Universidade Estadual Paulista São Paulo: Acervo Digital da UNESP / São Paulo State University |
op_collection_id |
ftunivesp |
language |
English |
topic |
Casearia sylvestris Chromosome aberration In vivo Micronucleus test Animalia Casearia Flacourtiaceae Mus Rattus Rattus norvegicus Rodentia |
spellingShingle |
Casearia sylvestris Chromosome aberration In vivo Micronucleus test Animalia Casearia Flacourtiaceae Mus Rattus Rattus norvegicus Rodentia Maistro, Edson Luis De Andrade, Sergio Faloni Puras, Marilane Aparecida Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays |
topic_facet |
Casearia sylvestris Chromosome aberration In vivo Micronucleus test Animalia Casearia Flacourtiaceae Mus Rattus Rattus norvegicus Rodentia |
description |
Casearia sylvestris (Flacourtiaceae) is a plant which grows in wild and has been widely used in folk medicine. In this study, clastogenic/aneugenic properties of Casearia sylvestris crude ethanolic extract were evaluated using in vivo chromosomal aberrations (CAs) and micronucleus (MN) assays in rodents. The animals were treated by gavage with 3 concentrations of the extract: 150, 300 and 500 mg/kg body weight. Bone marrow cells from Wistar rats were collected 24 h after having been submitted to the MN and CAs test. Peripheral blood cells from Swiss mice were collected 48 and 72 h after having been submitted to the MN test. The results show that C. sylvestris extract does not induce a significant increase in mean values for micronucleated polychromatic erythrocytes (MNPCE) in Swiss mice and Wistar rats, or CAs in rat bone marrow cells, at the 3 tested doses, indicating that the extract showed no clastogenic/aneugenic effects on chromosomes of the rodent cells tested. © 2007 The Japan Mendel Society. |
author2 |
Universidade Estadual Paulista (UNESP) |
format |
Other/Unknown Material |
author |
Maistro, Edson Luis De Andrade, Sergio Faloni Puras, Marilane Aparecida |
author_facet |
Maistro, Edson Luis De Andrade, Sergio Faloni Puras, Marilane Aparecida |
author_sort |
Maistro, Edson Luis |
title |
Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays |
title_short |
Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays |
title_full |
Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays |
title_fullStr |
Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays |
title_full_unstemmed |
Assessment of the potential clastogenic/aneugenic risk of Casearia sylvestris extract using in vivo assays |
title_sort |
assessment of the potential clastogenic/aneugenic risk of casearia sylvestris extract using in vivo assays |
publishDate |
2014 |
url |
http://acervodigital.unesp.br/handle/11449/70044 http://hdl.handle.net/11449/70044 https://doi.org/10.1508/cytologia.72.401 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
Cytologia Cytologia, v. 72, n. 4, p. 401-407, 2007. 0011-4545 http://hdl.handle.net/11449/70044 http://acervodigital.unesp.br/handle/11449/70044 doi:10.1508/cytologia.72.401 2-s2.0-39349107050.pdf 2-s2.0-39349107050 http://dx.doi.org/10.1508/cytologia.72.401 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1508/cytologia.72.401 |
container_title |
CYTOLOGIA |
container_volume |
72 |
container_issue |
4 |
container_start_page |
401 |
op_container_end_page |
407 |
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1766176788788019200 |