A block copolymer for functionalisation of polymersome surfaces
A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an ace...
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2008
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ftuniveindhoven:oai:library.tue.nl:882296 2023-05-15T14:01:45+02:00 A block copolymer for functionalisation of polymersome surfaces Dongen, SFM van Nallani, M Schoffelen, S Cornelissen, Jeroen JLM Nolte, RJM Roeland Hest, JCM Jan van 2008 application/pdf http://repository.tue.nl/882296 en eng Copyright (c) Dongen, SFM van Copyright (c) Nallani, M Copyright (c) Schoffelen, S Copyright (c) Cornelissen, Jeroen JLM Copyright (c) Nolte, RJM Roeland Copyright (c) Hest, JCM Jan van ISSN:1022-1336 Article / Letter to the editor 2008 ftuniveindhoven 2019-01-23T23:10:59Z A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome. Article in Journal/Newspaper Antarc* Antarctica Eindhoven University of Technology (TU/e): Research Portal |
institution |
Open Polar |
collection |
Eindhoven University of Technology (TU/e): Research Portal |
op_collection_id |
ftuniveindhoven |
language |
English |
description |
A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome. |
format |
Article in Journal/Newspaper |
author |
Dongen, SFM van Nallani, M Schoffelen, S Cornelissen, Jeroen JLM Nolte, RJM Roeland Hest, JCM Jan van |
spellingShingle |
Dongen, SFM van Nallani, M Schoffelen, S Cornelissen, Jeroen JLM Nolte, RJM Roeland Hest, JCM Jan van A block copolymer for functionalisation of polymersome surfaces |
author_facet |
Dongen, SFM van Nallani, M Schoffelen, S Cornelissen, Jeroen JLM Nolte, RJM Roeland Hest, JCM Jan van |
author_sort |
Dongen, SFM van |
title |
A block copolymer for functionalisation of polymersome surfaces |
title_short |
A block copolymer for functionalisation of polymersome surfaces |
title_full |
A block copolymer for functionalisation of polymersome surfaces |
title_fullStr |
A block copolymer for functionalisation of polymersome surfaces |
title_full_unstemmed |
A block copolymer for functionalisation of polymersome surfaces |
title_sort |
block copolymer for functionalisation of polymersome surfaces |
publishDate |
2008 |
url |
http://repository.tue.nl/882296 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
ISSN:1022-1336 |
op_rights |
Copyright (c) Dongen, SFM van Copyright (c) Nallani, M Copyright (c) Schoffelen, S Copyright (c) Cornelissen, Jeroen JLM Copyright (c) Nolte, RJM Roeland Copyright (c) Hest, JCM Jan van |
_version_ |
1766271785977774080 |