A block copolymer for functionalisation of polymersome surfaces

A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an ace...

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Main Authors: Dongen, SFM van, Nallani, M, Schoffelen, S, Cornelissen, Jeroen JLM, Nolte, RJM Roeland, Hest, JCM Jan van
Format: Article in Journal/Newspaper
Language:English
Published: 2008
Subjects:
Antarc*
Antarctica
Online Access:http://repository.tue.nl/882296
id ftuniveindhoven:oai:library.tue.nl:882296
record_format openpolar
spelling ftuniveindhoven:oai:library.tue.nl:882296 2023-05-15T14:01:45+02:00 A block copolymer for functionalisation of polymersome surfaces Dongen, SFM van Nallani, M Schoffelen, S Cornelissen, Jeroen JLM Nolte, RJM Roeland Hest, JCM Jan van 2008 application/pdf http://repository.tue.nl/882296 en eng Copyright (c) Dongen, SFM van Copyright (c) Nallani, M Copyright (c) Schoffelen, S Copyright (c) Cornelissen, Jeroen JLM Copyright (c) Nolte, RJM Roeland Copyright (c) Hest, JCM Jan van ISSN:1022-1336 Article / Letter to the editor 2008 ftuniveindhoven 2019-01-23T23:10:59Z A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome. Article in Journal/Newspaper Antarc* Antarctica Eindhoven University of Technology (TU/e): Research Portal
institution Open Polar
collection Eindhoven University of Technology (TU/e): Research Portal
op_collection_id ftuniveindhoven
language English
description A block copolymer was designed to functionalise the surface of polystyrene-based polymersomes via coaggregation. An α,ω- diacetylene-functionalised poly(ethylene glycol) (PEG) was coupled to an azide-terminated polystyrene via a Cu(I)-catalysed cycloaddition to produce a PS-b-PEG polymer with an acetylene at its hydrophilic extremity. Incorporation of this 'anchor' compound in the bilayer of a polymersome places its bio-orthogonal group at the surface of this aggregate. Its accessibility was demonstrated using an azidofunctionalised Candida antarctica Lipase B (CalB), which retained its activity while immobilised on the polymersome.
format Article in Journal/Newspaper
author Dongen, SFM van
Nallani, M
Schoffelen, S
Cornelissen, Jeroen JLM
Nolte, RJM Roeland
Hest, JCM Jan van
spellingShingle Dongen, SFM van
Nallani, M
Schoffelen, S
Cornelissen, Jeroen JLM
Nolte, RJM Roeland
Hest, JCM Jan van
A block copolymer for functionalisation of polymersome surfaces
author_facet Dongen, SFM van
Nallani, M
Schoffelen, S
Cornelissen, Jeroen JLM
Nolte, RJM Roeland
Hest, JCM Jan van
author_sort Dongen, SFM van
title A block copolymer for functionalisation of polymersome surfaces
title_short A block copolymer for functionalisation of polymersome surfaces
title_full A block copolymer for functionalisation of polymersome surfaces
title_fullStr A block copolymer for functionalisation of polymersome surfaces
title_full_unstemmed A block copolymer for functionalisation of polymersome surfaces
title_sort block copolymer for functionalisation of polymersome surfaces
publishDate 2008
url http://repository.tue.nl/882296
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_source ISSN:1022-1336
op_rights Copyright (c) Dongen, SFM van
Copyright (c) Nallani, M
Copyright (c) Schoffelen, S
Copyright (c) Cornelissen, Jeroen JLM
Copyright (c) Nolte, RJM Roeland
Copyright (c) Hest, JCM Jan van
_version_ 1766271785977774080

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