Visceral Leishmaniasis and Hemophagocytic Lymphohistiocytosis in an Adult Patient
Leishmaniasis is a vector borne zoonotic parasitic disease transmitted by sand flies and it can be seen in all continents except Antarctica. It is a common disease in the countries located in Mediterranean basin (Turkey, Syria, North Africa, Jordan, Italy, Iran). It may present with three clinical f...
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ftunivege:oai:acikerisim.ege.edu.tr:11454/62489 2023-05-15T13:48:25+02:00 Visceral Leishmaniasis and Hemophagocytic Lymphohistiocytosis in an Adult Patient Kilincer Bozgul, Sukriya Miray Emgin, Omer Akad Soyer, Nur Ulusan, Oziem Bozkurt, Devrim Ege Üniversitesi 2020 https://hdl.handle.net/11454/62489 https://doi.org/10.5578/mb.68974 tur tur Ankara Microbiology Soc 10.5578/mb.68974 Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı Mikrobiyoloji Bulteni 0374-9096 https://doi.org/10.5578/mb.68974 https://hdl.handle.net/11454/62489 54 2 339 346 WOS:000528257000015 2-s2.0-85088882174 32723289 info:eu-repo/semantics/closedAccess Hemophagocytosis hemophagocytic lymphohistiocytosis leishmaniasis viceral leishmaniasis article 2020 ftunivege https://doi.org/10.5578/mb.68974 2023-01-12T17:47:49Z Leishmaniasis is a vector borne zoonotic parasitic disease transmitted by sand flies and it can be seen in all continents except Antarctica. It is a common disease in the countries located in Mediterranean basin (Turkey, Syria, North Africa, Jordan, Italy, Iran). It may present with three clinical forms such as cutaneous, mucocutaneous visceral leishmaniasis (VL). VL is an endemic disease in the Mediterranean and Aegean regions of Turkey and it is seen sporadically in the other regions. in this report a case who is living in Izmir province with hemophagocytic lymphohistiocytosis (HLH) secondary to VL was presented. A 50-year-old woman admitted to our department with fever, weakness, sweating and fatique for about three weeks. the patient's temperature was 38.7 degrees C. Laboratory tests revealed pancytopenia with hemoglobin level of 8.91 g/dl (11.7-16.0 g/dl), platelet level 10(4) x 10(3)/mu l (150-450 x 10(3)/mu l) and leukocyte (1.35 x 10(3)/mu l (4.5-11 x 10(3)/mu l) counts. Ferritin and triglyceride levels were increased. Ferritin level was 764.4 ng/ml (13-150 x 10(3)/mu l) and triglyceride level was 232 mg/dl (< 150 mg/dl). HLH was diagnosed according to the 2004 HLH current diagnostic guidelines. After this diagnosis the patient was investigated for underlying disease such as malignancy, autoimmune diseases, medications and infectious diseases. Bone marrow aspiration showed hemophagocytosis and intracellular Leishmania amastigotes. Leishmania indirect fluorescent antibody IgG (IFAT) was positive in titre of (1/1024). in addition, in the bone marrow aspiration sample taken from the patient, the causative agent of leishmaniasis was searched by polymerase chain reaction, and it was determined that etiological agent was Leishmania infantum. the patient was evaluated as HLH secondary to VL. Liposomal amphotericin B therapy was started and in the 5th day of treatment, the patient's fever was measured as normal. There was a significant decrease in fatigue and sweating. After two months of treatment, the ... Article in Journal/Newspaper Antarc* Antarctica Ege University Institutional Repository Mikrobiyoloji Bulteni 54 2 339 346 |
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Ege University Institutional Repository |
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Turkish |
topic |
Hemophagocytosis hemophagocytic lymphohistiocytosis leishmaniasis viceral leishmaniasis |
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Hemophagocytosis hemophagocytic lymphohistiocytosis leishmaniasis viceral leishmaniasis Kilincer Bozgul, Sukriya Miray Emgin, Omer Akad Soyer, Nur Ulusan, Oziem Bozkurt, Devrim Visceral Leishmaniasis and Hemophagocytic Lymphohistiocytosis in an Adult Patient |
topic_facet |
Hemophagocytosis hemophagocytic lymphohistiocytosis leishmaniasis viceral leishmaniasis |
description |
Leishmaniasis is a vector borne zoonotic parasitic disease transmitted by sand flies and it can be seen in all continents except Antarctica. It is a common disease in the countries located in Mediterranean basin (Turkey, Syria, North Africa, Jordan, Italy, Iran). It may present with three clinical forms such as cutaneous, mucocutaneous visceral leishmaniasis (VL). VL is an endemic disease in the Mediterranean and Aegean regions of Turkey and it is seen sporadically in the other regions. in this report a case who is living in Izmir province with hemophagocytic lymphohistiocytosis (HLH) secondary to VL was presented. A 50-year-old woman admitted to our department with fever, weakness, sweating and fatique for about three weeks. the patient's temperature was 38.7 degrees C. Laboratory tests revealed pancytopenia with hemoglobin level of 8.91 g/dl (11.7-16.0 g/dl), platelet level 10(4) x 10(3)/mu l (150-450 x 10(3)/mu l) and leukocyte (1.35 x 10(3)/mu l (4.5-11 x 10(3)/mu l) counts. Ferritin and triglyceride levels were increased. Ferritin level was 764.4 ng/ml (13-150 x 10(3)/mu l) and triglyceride level was 232 mg/dl (< 150 mg/dl). HLH was diagnosed according to the 2004 HLH current diagnostic guidelines. After this diagnosis the patient was investigated for underlying disease such as malignancy, autoimmune diseases, medications and infectious diseases. Bone marrow aspiration showed hemophagocytosis and intracellular Leishmania amastigotes. Leishmania indirect fluorescent antibody IgG (IFAT) was positive in titre of (1/1024). in addition, in the bone marrow aspiration sample taken from the patient, the causative agent of leishmaniasis was searched by polymerase chain reaction, and it was determined that etiological agent was Leishmania infantum. the patient was evaluated as HLH secondary to VL. Liposomal amphotericin B therapy was started and in the 5th day of treatment, the patient's fever was measured as normal. There was a significant decrease in fatigue and sweating. After two months of treatment, the ... |
author2 |
Ege Üniversitesi |
format |
Article in Journal/Newspaper |
author |
Kilincer Bozgul, Sukriya Miray Emgin, Omer Akad Soyer, Nur Ulusan, Oziem Bozkurt, Devrim |
author_facet |
Kilincer Bozgul, Sukriya Miray Emgin, Omer Akad Soyer, Nur Ulusan, Oziem Bozkurt, Devrim |
author_sort |
Kilincer Bozgul, Sukriya Miray |
title |
Visceral Leishmaniasis and Hemophagocytic Lymphohistiocytosis in an Adult Patient |
title_short |
Visceral Leishmaniasis and Hemophagocytic Lymphohistiocytosis in an Adult Patient |
title_full |
Visceral Leishmaniasis and Hemophagocytic Lymphohistiocytosis in an Adult Patient |
title_fullStr |
Visceral Leishmaniasis and Hemophagocytic Lymphohistiocytosis in an Adult Patient |
title_full_unstemmed |
Visceral Leishmaniasis and Hemophagocytic Lymphohistiocytosis in an Adult Patient |
title_sort |
visceral leishmaniasis and hemophagocytic lymphohistiocytosis in an adult patient |
publisher |
Ankara Microbiology Soc |
publishDate |
2020 |
url |
https://hdl.handle.net/11454/62489 https://doi.org/10.5578/mb.68974 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
10.5578/mb.68974 Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı Mikrobiyoloji Bulteni 0374-9096 https://doi.org/10.5578/mb.68974 https://hdl.handle.net/11454/62489 54 2 339 346 WOS:000528257000015 2-s2.0-85088882174 32723289 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.5578/mb.68974 |
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Mikrobiyoloji Bulteni |
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54 |
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2 |
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339 |
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346 |
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