Resequencing study confirms that host defense and cell senescence gene variants contribute to the risk of idiopathic pulmonary fibrosis

• Published in: American Journal of Respiratory and Critical Care Medicine
• Main Authors: Moore C., Blumhagen R.Z., Yang I.V., Walts A., Powers J., Walker T., Bishop M., Russell P., Vestal B., Cardwell J., Markin C.R., Mathai S.K., Schwarz M.I., Steele M.P., Lee J., Brown K.K., Loyd J.E., Crapo J.D., Silverman E.K., Cho M.H., James J.A., Guthridge J.M., Cogan J.D., Kropski J.A., Swigris J.J., Bair C., Kim D.S., Ji W., Kim H., Song J.W., Maier L.A., Pacheco K.A., Hirani N., Poon A.S., Li F., Gisli Jenkins R., Braybrooke R., Saini G., Maher T.M., Molyneaux P.L., Saunders P., Zhang Y., Gibson K.F., Kass D.J., Rojas M., Sembrat J., Wolters P.J., Collard H.R., Sundy J.S., O'Riordan T., Strek M.E., Noth I., Ma S.-F., Porteous M.K., Kreider M.E., Patel N.B., Inoue Y., Hirose M., Arai T., Akagawa S., Eickelberg O., Fernandez I.E., Behr J., Mogulkoc N., Corte T.J., Glaspole I., Tomassetti S., Ravaglia C., Poletti V., Crestani B., Borie R., Kannengiesser C., Parfrey H., Fiddler C., Rassl D., Molina-Molina M., Machahua C., Worboys A.M., Gudmundsson G., Isaksson H.J., Lederer D.J., Podolanczuk A.J., Montesi S.B., Bendstrup E., Danchel V., Selman M., Pardo A., Henry M.T., Keane M.P., Doran P., Vašáková M., Sterclova M., Ryerson C.J., Wilcox P.G., Okamoto T., Furusawa H., Miyazaki Y., Laurent G., Baltic S., Prele C., Moodley Y., Shea B.S., Ohta K., Suzukawa M., Narumoto O., Nathan S.D., Venuto D.C., Woldehanna M.L., Kokturk N., De Andrade J.A., Luckhardt T., Kulkarni T., Bonella F., Donnelly S.C., McElroy A., Armstong M.E., Aranda A., Carbone R.G., Puppo F., Beckman K.B., Nickerson D.A., Fingerlin T.E., Schwartz D.A.
• Other Authors: Ege Üniversitesi
• Format: Article in Journal/Newspaper
• Language: English
• Published: American Thoracic Society 2019
• Subjects: Disease risk alleles; Genetic variants; Idiopathic pulmonary fibrosis; Rare variants; Targeted resequencing; Alabama; British Columbia; Canada; Ege; Háskóli Íslands; Villegas; Iceland
• Online Access: https://hdl.handle.net/11454/25019; https://doi.org/10.1164/rccm.201810-1891OC

###EgeUn### Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. Objectives: To develop an integrated understanding of the rare and common variants located in multiple loci that ha...