Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae)
Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological as well as behavioral differences. Each species has had its own evolutionary trajectory, formed by many types of selection pressures and ra...
Main Authors: | , , , , , , , |
---|---|
Language: | unknown |
Published: |
2022
|
Subjects: | |
Online Access: | https://doi.org/10.5061/dryad.p8cz8w9sm https://erepo.uef.fi/handle/123456789/28377 |
id |
ftuniveasternfin:oai:erepo.uef.fi:123456789/28377 |
---|---|
record_format |
openpolar |
spelling |
ftuniveasternfin:oai:erepo.uef.fi:123456789/28377 2023-05-15T15:06:17+02:00 Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) Gaertner, Kateryna,Tampere University Michell, Craig,University of Eastern Finland Tapanainen, Riikka,University of Eastern Finland Goffart, Steffi,University of Eastern Finland Saari, Sina,Tampere University Soininmäki, Manu,Tampere University Dufour, Eric,Tampere University Pohjoismäki, Jaakko,University of Eastern Finland 2022-10-05T02:05:16Z https://doi.org/10.5061/dryad.p8cz8w9sm https://erepo.uef.fi/handle/123456789/28377 unknown https://zenodo.org/record/7131709 10.5061/dryad.p8cz8w9sm doi:10.5061/dryad.p8cz8w9sm https://erepo.uef.fi/handle/123456789/28377 speciation Genome metabolism Animal evolution Lepus Lepus timidus Lepus europaeus 2022 ftuniveasternfin https://doi.org/10.5061/dryad.p8cz8w9sm 2022-12-11T06:55:34Z Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological as well as behavioral differences. Each species has had its own evolutionary trajectory, formed by many types of selection pressures and random drift, making it extremely complicated to associate genetic differences between the species with the phenotypic differences. In the present study, we have used an in vitro model to analyze in depth the genetic and gene regulation differences between fibroblasts of two closely related mammals, arctic/subarctic mountain hare (Lepus timidus Linnaeus) and a temperate, steppe-like climate adapted brown hare (Lepus europaeus Pallas). We discovered the existence of a species-specific expression pattern of 1,623 genes, manifesting in differences in cell growth, respiration, and metabolism. Interspecific differences in the housekeeping functions of fibroblast cells suggest speciation acts on fundamental processes, even in these two interfertile species. Our results help to understand the molecular constituents of a species difference on a cellular level, which could contribute to the maintenance of the species boundary. Other/Unknown Material Arctic Lepus timidus mountain hare Subarctic UEF eRepository (University of Eastern Finland) Arctic |
institution |
Open Polar |
collection |
UEF eRepository (University of Eastern Finland) |
op_collection_id |
ftuniveasternfin |
language |
unknown |
topic |
speciation Genome metabolism Animal evolution Lepus Lepus timidus Lepus europaeus |
spellingShingle |
speciation Genome metabolism Animal evolution Lepus Lepus timidus Lepus europaeus Gaertner, Kateryna,Tampere University Michell, Craig,University of Eastern Finland Tapanainen, Riikka,University of Eastern Finland Goffart, Steffi,University of Eastern Finland Saari, Sina,Tampere University Soininmäki, Manu,Tampere University Dufour, Eric,Tampere University Pohjoismäki, Jaakko,University of Eastern Finland Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
topic_facet |
speciation Genome metabolism Animal evolution Lepus Lepus timidus Lepus europaeus |
description |
Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological, physiological as well as behavioral differences. Each species has had its own evolutionary trajectory, formed by many types of selection pressures and random drift, making it extremely complicated to associate genetic differences between the species with the phenotypic differences. In the present study, we have used an in vitro model to analyze in depth the genetic and gene regulation differences between fibroblasts of two closely related mammals, arctic/subarctic mountain hare (Lepus timidus Linnaeus) and a temperate, steppe-like climate adapted brown hare (Lepus europaeus Pallas). We discovered the existence of a species-specific expression pattern of 1,623 genes, manifesting in differences in cell growth, respiration, and metabolism. Interspecific differences in the housekeeping functions of fibroblast cells suggest speciation acts on fundamental processes, even in these two interfertile species. Our results help to understand the molecular constituents of a species difference on a cellular level, which could contribute to the maintenance of the species boundary. |
author |
Gaertner, Kateryna,Tampere University Michell, Craig,University of Eastern Finland Tapanainen, Riikka,University of Eastern Finland Goffart, Steffi,University of Eastern Finland Saari, Sina,Tampere University Soininmäki, Manu,Tampere University Dufour, Eric,Tampere University Pohjoismäki, Jaakko,University of Eastern Finland |
author_facet |
Gaertner, Kateryna,Tampere University Michell, Craig,University of Eastern Finland Tapanainen, Riikka,University of Eastern Finland Goffart, Steffi,University of Eastern Finland Saari, Sina,Tampere University Soininmäki, Manu,Tampere University Dufour, Eric,Tampere University Pohjoismäki, Jaakko,University of Eastern Finland |
author_sort |
Gaertner, Kateryna,Tampere University |
title |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_short |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_full |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_fullStr |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_full_unstemmed |
Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae) |
title_sort |
molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (lepus spp., lagomorpha: leporidae) |
publishDate |
2022 |
url |
https://doi.org/10.5061/dryad.p8cz8w9sm https://erepo.uef.fi/handle/123456789/28377 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Lepus timidus mountain hare Subarctic |
genre_facet |
Arctic Lepus timidus mountain hare Subarctic |
op_relation |
https://zenodo.org/record/7131709 10.5061/dryad.p8cz8w9sm doi:10.5061/dryad.p8cz8w9sm https://erepo.uef.fi/handle/123456789/28377 |
op_doi |
https://doi.org/10.5061/dryad.p8cz8w9sm |
_version_ |
1766337924744347648 |