Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study
Article High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortali...
Published in: | Psychiatry Research: Neuroimaging |
---|---|
Main Authors: | , , , , , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Elsevier BV
2017
|
Subjects: | |
Online Access: | https://doi.org/10.1016/j.pscychresns.2017.05.009 https://erepo.uef.fi/handle/123456789/2625 |
id |
ftuniveasternfin:oai:erepo.uef.fi:123456789/2625 |
---|---|
record_format |
openpolar |
spelling |
ftuniveasternfin:oai:erepo.uef.fi:123456789/2625 2024-06-16T07:42:09+00:00 Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study Huhtaniska S Jääskeläinen E Heikka T. Moilanen JS Lehtiniemi H Tohka J Manjón JV Coupé P Björnholm L Koponen H Veijola J Isohanni M Kiviniemi V Murray GK Miettunen J A.I. Virtanen -instituutti 2017-06-26T12:18:08Z 73-82 https://doi.org/10.1016/j.pscychresns.2017.05.009 https://erepo.uef.fi/handle/123456789/2625 EN eng Elsevier BV PSYCHIATRY RESEARCH: NEUROIMAGING http://dx.doi.org/10.1016/j.pscychresns.2017.05.009 10.1016/j.pscychresns.2017.05.009 0925-4927 266 doi:10.1016/j.pscychresns.2017.05.009 https://erepo.uef.fi/handle/123456789/2625 CC BY-NC-ND 4.0 openAccess © Elsevier Inc https://creativecommons.org/licenses/by-nc-nd/4.0/ Schizophrenia Antipsychotics Benzodiazepines Brain MRI http://purl.org/eprint/type/JournalArticle info:eu-repo/semantics/article article artikkeli 2017 ftuniveasternfin https://doi.org/10.1016/j.pscychresns.2017.05.009 2024-05-23T03:07:27Z Article High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality. In this Northern Finland Birth Cohort 1966 study, 69 controls and 38 individuals with schizophrenia underwent brain MRI at the ages of 34 and 43 years. At baseline, the average illness duration was over 10 years. Brain structures were delineated using an automated volumetry system, volBrain, and medication data on cumulative antipsychotic and benzodiazepine doses were collected using medical records and interviews. We used linear regression with intracranial volume and sex as covariates; illness severity was also taken into account. Though both medication doses associated to volumetric changes in subcortical structures, after adjusting for each other and the average PANSS total score, higher scan-interval antipsychotic dose associated only to volume increase in lateral ventricles and higher benzodiazepine dose associated with volume decrease in the caudate nucleus. To our knowledge, there are no previous studies reporting associations between benzodiazepine dose and brain structural changes. Further studies should focus on how these observations correspond to cognition and functioning. final draft http://purl.org/eprint/status/PeerReviewed Article in Journal/Newspaper Northern Finland UEF eRepository (University of Eastern Finland) Psychiatry Research: Neuroimaging 266 73 82 |
institution |
Open Polar |
collection |
UEF eRepository (University of Eastern Finland) |
op_collection_id |
ftuniveasternfin |
language |
English |
topic |
Schizophrenia Antipsychotics Benzodiazepines Brain MRI |
spellingShingle |
Schizophrenia Antipsychotics Benzodiazepines Brain MRI Huhtaniska S Jääskeläinen E Heikka T. Moilanen JS Lehtiniemi H Tohka J Manjón JV Coupé P Björnholm L Koponen H Veijola J Isohanni M Kiviniemi V Murray GK Miettunen J Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
topic_facet |
Schizophrenia Antipsychotics Benzodiazepines Brain MRI |
description |
Article High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality. In this Northern Finland Birth Cohort 1966 study, 69 controls and 38 individuals with schizophrenia underwent brain MRI at the ages of 34 and 43 years. At baseline, the average illness duration was over 10 years. Brain structures were delineated using an automated volumetry system, volBrain, and medication data on cumulative antipsychotic and benzodiazepine doses were collected using medical records and interviews. We used linear regression with intracranial volume and sex as covariates; illness severity was also taken into account. Though both medication doses associated to volumetric changes in subcortical structures, after adjusting for each other and the average PANSS total score, higher scan-interval antipsychotic dose associated only to volume increase in lateral ventricles and higher benzodiazepine dose associated with volume decrease in the caudate nucleus. To our knowledge, there are no previous studies reporting associations between benzodiazepine dose and brain structural changes. Further studies should focus on how these observations correspond to cognition and functioning. final draft http://purl.org/eprint/status/PeerReviewed |
author2 |
A.I. Virtanen -instituutti |
format |
Article in Journal/Newspaper |
author |
Huhtaniska S Jääskeläinen E Heikka T. Moilanen JS Lehtiniemi H Tohka J Manjón JV Coupé P Björnholm L Koponen H Veijola J Isohanni M Kiviniemi V Murray GK Miettunen J |
author_facet |
Huhtaniska S Jääskeläinen E Heikka T. Moilanen JS Lehtiniemi H Tohka J Manjón JV Coupé P Björnholm L Koponen H Veijola J Isohanni M Kiviniemi V Murray GK Miettunen J |
author_sort |
Huhtaniska S |
title |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_short |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_full |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_fullStr |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_full_unstemmed |
Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study |
title_sort |
long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: the northern finland birth cohort 1966 study |
publisher |
Elsevier BV |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.pscychresns.2017.05.009 https://erepo.uef.fi/handle/123456789/2625 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
PSYCHIATRY RESEARCH: NEUROIMAGING http://dx.doi.org/10.1016/j.pscychresns.2017.05.009 10.1016/j.pscychresns.2017.05.009 0925-4927 266 doi:10.1016/j.pscychresns.2017.05.009 https://erepo.uef.fi/handle/123456789/2625 |
op_rights |
CC BY-NC-ND 4.0 openAccess © Elsevier Inc https://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.1016/j.pscychresns.2017.05.009 |
container_title |
Psychiatry Research: Neuroimaging |
container_volume |
266 |
container_start_page |
73 |
op_container_end_page |
82 |
_version_ |
1802009534478155776 |