Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface
Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in...
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ftuniveastangl:oai:ueaeprints.uea.ac.uk:74286 2023-05-15T15:30:52+02:00 Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. 2020-02-07 application/pdf https://ueaeprints.uea.ac.uk/id/eprint/74286/ https://ueaeprints.uea.ac.uk/id/eprint/74286/2/Published_Version.pdf https://doi.org/10.1186/s12863-020-0816-y en eng https://ueaeprints.uea.ac.uk/id/eprint/74286/2/Published_Version.pdf Besnier, Francois, Solberg, Monica F., Harvey, Alison C., Carvalho, Gary R., Bekkevold, Dorte, Taylor, Martin I., Creer, Simon, Nielsen, Einar E., Skaala, Øystein, Ayllon, Fernando, Dahle, Geir and Glover, Kevin A. (2020) Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface. BMC Genetics, 21 (1). ISSN 1943-2631 doi:10.1186/s12863-020-0816-y cc_by CC-BY Article PeerReviewed 2020 ftuniveastangl https://doi.org/10.1186/s12863-020-0816-y 2023-01-30T21:52:03Z Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations. Results After rearing fish in common-garden experiments under aquaculture conditions, we performed a variance component analysis in four mapping populations totaling similar to 7000 individuals from six wild, two domesticated and three F1 wild/domesticated hybrid strains. Across the four independent datasets, genome-wide significant quantitative trait loci (QTLs) associated with weight and length were detected on a total of 18 chromosomes, reflecting the polygenic nature of growth. Significant QTLs correlated with both length and weight were detected on chromosomes 2, 6 and 9 in multiple datasets. Significantly, epistatic QTLs were detected in all datasets. Discussion The observed interactions demonstrated that the phenotypic effect of inheriting an allele deviated between half-sib families. Gene-by-gene interactions were also suggested, where the combined effect of two loci resulted in a genetic effect upon phenotypic variance, while no genetic effect was detected when the two loci were considered separately. To our knowledge, this is the first documentation of epistasis in a quantitative trait in Atlantic salmon. These novel results are of relevance for breeding programs, and for predicting the evolutionary consequences of domestication-introgression in wild populations. Article in Journal/Newspaper Atlantic salmon University of East Anglia: UEA Digital Repository BMC Genetics 21 1 |
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Open Polar |
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University of East Anglia: UEA Digital Repository |
op_collection_id |
ftuniveastangl |
language |
English |
description |
Background Quantitative traits are typically considered to be under additive genetic control. Although there are indications that non-additive factors have the potential to contribute to trait variation, experimental demonstration remains scarce. Here, we investigated the genetic basis of growth in Atlantic salmon by exploiting the high level of genetic diversity and trait expression among domesticated, hybrid and wild populations. Results After rearing fish in common-garden experiments under aquaculture conditions, we performed a variance component analysis in four mapping populations totaling similar to 7000 individuals from six wild, two domesticated and three F1 wild/domesticated hybrid strains. Across the four independent datasets, genome-wide significant quantitative trait loci (QTLs) associated with weight and length were detected on a total of 18 chromosomes, reflecting the polygenic nature of growth. Significant QTLs correlated with both length and weight were detected on chromosomes 2, 6 and 9 in multiple datasets. Significantly, epistatic QTLs were detected in all datasets. Discussion The observed interactions demonstrated that the phenotypic effect of inheriting an allele deviated between half-sib families. Gene-by-gene interactions were also suggested, where the combined effect of two loci resulted in a genetic effect upon phenotypic variance, while no genetic effect was detected when the two loci were considered separately. To our knowledge, this is the first documentation of epistasis in a quantitative trait in Atlantic salmon. These novel results are of relevance for breeding programs, and for predicting the evolutionary consequences of domestication-introgression in wild populations. |
format |
Article in Journal/Newspaper |
author |
Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. |
spellingShingle |
Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface |
author_facet |
Besnier, Francois Solberg, Monica F. Harvey, Alison C. Carvalho, Gary R. Bekkevold, Dorte Taylor, Martin I. Creer, Simon Nielsen, Einar E. Skaala, Øystein Ayllon, Fernando Dahle, Geir Glover, Kevin A. |
author_sort |
Besnier, Francois |
title |
Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface |
title_short |
Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface |
title_full |
Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface |
title_fullStr |
Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface |
title_full_unstemmed |
Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface |
title_sort |
epistatic regulation of growth in atlantic salmon revealed:a qtl study performed on the domesticated-wild interface |
publishDate |
2020 |
url |
https://ueaeprints.uea.ac.uk/id/eprint/74286/ https://ueaeprints.uea.ac.uk/id/eprint/74286/2/Published_Version.pdf https://doi.org/10.1186/s12863-020-0816-y |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
https://ueaeprints.uea.ac.uk/id/eprint/74286/2/Published_Version.pdf Besnier, Francois, Solberg, Monica F., Harvey, Alison C., Carvalho, Gary R., Bekkevold, Dorte, Taylor, Martin I., Creer, Simon, Nielsen, Einar E., Skaala, Øystein, Ayllon, Fernando, Dahle, Geir and Glover, Kevin A. (2020) Epistatic regulation of growth in Atlantic salmon revealed:A QTL study performed on the domesticated-wild interface. BMC Genetics, 21 (1). ISSN 1943-2631 doi:10.1186/s12863-020-0816-y |
op_rights |
cc_by |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/s12863-020-0816-y |
container_title |
BMC Genetics |
container_volume |
21 |
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1 |
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1766361334336716800 |