The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life:a 34-year follow-up of the Northern Finland 1966 birth cohort
Childhood precursors of schizophrenia include multiple abnormalities of development. Continuities between early and subsequent deviance are poorly characterised. We studied associations among premorbid developmental deviance using data at ages 1 year (learning to stand, walk, and speak, attainment o...
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ftunivdundeepure:oai:discovery.dundee.ac.uk:publications/1ee6010e-0d64-4a06-a491-756363b0e2ee 2024-09-09T19:59:18+00:00 The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life:a 34-year follow-up of the Northern Finland 1966 birth cohort Isohanni, Matti Murray, Graham K. Jokelainen, Jari Croudace, Tim Jones, Peter B. 2004-12 https://discovery.dundee.ac.uk/en/publications/1ee6010e-0d64-4a06-a491-756363b0e2ee https://doi.org/10.1016/j.schres.2004.03.008 http://www.scopus.com/record/display.url?eid=2-s2.0-4944236441&origin=resultslist&sort=plf-f&src=s&st1=The+persistence+of+developmental+markers+in+childhood+and+adolescence+and+risk+for+schizophrenic+psychoses+in+adult+life.+A+34-year+follow-up+of+the+Northern+Finland+1966+birth+cohort&sid=A2DF6912D7E54AB287DAF61C13842E2E.y7ESLndDIsN8cE7qwvy6w%3a610&sot=b&sdt=b&sl=198&s=TITLE-ABS-KEY%28The+persistence+of+developmental+markers+in+childhood+and+adolescence+and+risk+for+schizophrenic+psychoses+in+adult+life.+A+34-year+follow-up+of+the+Northern+Finland+1966+birth+cohort%29&relpos=0&relpos=0&citeCnt=33&searchTerm=TITLE-ABS-KEY%28The+persistence+of+developmental+markers+in+childhood+and+adolescence+and+risk+for+schizophrenic+psychoses+in+adult+life.+A+34-year+follow-up+of+the+Northern+Finland+1966+birth+cohort%29 eng eng https://discovery.dundee.ac.uk/en/publications/1ee6010e-0d64-4a06-a491-756363b0e2ee info:eu-repo/semantics/restrictedAccess Isohanni , M , Murray , G K , Jokelainen , J , Croudace , T & Jones , P B 2004 , ' The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life : a 34-year follow-up of the Northern Finland 1966 birth cohort ' , Schizophrenia Research , vol. 71 , no. 2-3 , pp. 213-225 . https://doi.org/10.1016/j.schres.2004.03.008 article 2004 ftunivdundeepure https://doi.org/10.1016/j.schres.2004.03.008 2024-07-09T14:14:09Z Childhood precursors of schizophrenia include multiple abnormalities of development. Continuities between early and subsequent deviance are poorly characterised. We studied associations among premorbid developmental deviance using data at ages 1 year (learning to stand, walk, and speak, attainment of bladder and bowel control) and 16 years (success at school). Generalised linear modelling was used to examine differential linear associations and trends across adult psychiatric diagnoses. In babies who, as adults, suffered schizophrenia or any psychosis, those who learned to stand latest were also more likely to perform poorly at school in both motor and theoretical domains at age 16 when compared with earlier learners. The effect was independent of genetic and perinatal factors. We conclude that the early developmental deviation in the first year of life is associated with lower school performance at age 16. Developmental continuity among children who develop psychoses was stronger than among normal controls and those hospitalized for nonpsychotic psychiatric disorder. These findings are in line with the hypothesis that a neural diathesis is present during postnatal brain development before schizophrenia. This supports the longitudinal dimension and life span models of schizophrenia. Article in Journal/Newspaper Northern Finland Discovery - University of Dundee Online Publications Schizophrenia Research 71 2-3 213 225 |
institution |
Open Polar |
collection |
Discovery - University of Dundee Online Publications |
op_collection_id |
ftunivdundeepure |
language |
English |
description |
Childhood precursors of schizophrenia include multiple abnormalities of development. Continuities between early and subsequent deviance are poorly characterised. We studied associations among premorbid developmental deviance using data at ages 1 year (learning to stand, walk, and speak, attainment of bladder and bowel control) and 16 years (success at school). Generalised linear modelling was used to examine differential linear associations and trends across adult psychiatric diagnoses. In babies who, as adults, suffered schizophrenia or any psychosis, those who learned to stand latest were also more likely to perform poorly at school in both motor and theoretical domains at age 16 when compared with earlier learners. The effect was independent of genetic and perinatal factors. We conclude that the early developmental deviation in the first year of life is associated with lower school performance at age 16. Developmental continuity among children who develop psychoses was stronger than among normal controls and those hospitalized for nonpsychotic psychiatric disorder. These findings are in line with the hypothesis that a neural diathesis is present during postnatal brain development before schizophrenia. This supports the longitudinal dimension and life span models of schizophrenia. |
format |
Article in Journal/Newspaper |
author |
Isohanni, Matti Murray, Graham K. Jokelainen, Jari Croudace, Tim Jones, Peter B. |
spellingShingle |
Isohanni, Matti Murray, Graham K. Jokelainen, Jari Croudace, Tim Jones, Peter B. The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life:a 34-year follow-up of the Northern Finland 1966 birth cohort |
author_facet |
Isohanni, Matti Murray, Graham K. Jokelainen, Jari Croudace, Tim Jones, Peter B. |
author_sort |
Isohanni, Matti |
title |
The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life:a 34-year follow-up of the Northern Finland 1966 birth cohort |
title_short |
The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life:a 34-year follow-up of the Northern Finland 1966 birth cohort |
title_full |
The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life:a 34-year follow-up of the Northern Finland 1966 birth cohort |
title_fullStr |
The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life:a 34-year follow-up of the Northern Finland 1966 birth cohort |
title_full_unstemmed |
The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life:a 34-year follow-up of the Northern Finland 1966 birth cohort |
title_sort |
persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life:a 34-year follow-up of the northern finland 1966 birth cohort |
publishDate |
2004 |
url |
https://discovery.dundee.ac.uk/en/publications/1ee6010e-0d64-4a06-a491-756363b0e2ee https://doi.org/10.1016/j.schres.2004.03.008 http://www.scopus.com/record/display.url?eid=2-s2.0-4944236441&origin=resultslist&sort=plf-f&src=s&st1=The+persistence+of+developmental+markers+in+childhood+and+adolescence+and+risk+for+schizophrenic+psychoses+in+adult+life.+A+34-year+follow-up+of+the+Northern+Finland+1966+birth+cohort&sid=A2DF6912D7E54AB287DAF61C13842E2E.y7ESLndDIsN8cE7qwvy6w%3a610&sot=b&sdt=b&sl=198&s=TITLE-ABS-KEY%28The+persistence+of+developmental+markers+in+childhood+and+adolescence+and+risk+for+schizophrenic+psychoses+in+adult+life.+A+34-year+follow-up+of+the+Northern+Finland+1966+birth+cohort%29&relpos=0&relpos=0&citeCnt=33&searchTerm=TITLE-ABS-KEY%28The+persistence+of+developmental+markers+in+childhood+and+adolescence+and+risk+for+schizophrenic+psychoses+in+adult+life.+A+34-year+follow-up+of+the+Northern+Finland+1966+birth+cohort%29 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Isohanni , M , Murray , G K , Jokelainen , J , Croudace , T & Jones , P B 2004 , ' The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life : a 34-year follow-up of the Northern Finland 1966 birth cohort ' , Schizophrenia Research , vol. 71 , no. 2-3 , pp. 213-225 . https://doi.org/10.1016/j.schres.2004.03.008 |
op_relation |
https://discovery.dundee.ac.uk/en/publications/1ee6010e-0d64-4a06-a491-756363b0e2ee |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.schres.2004.03.008 |
container_title |
Schizophrenia Research |
container_volume |
71 |
container_issue |
2-3 |
container_start_page |
213 |
op_container_end_page |
225 |
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1809930433020821504 |