Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water
Laboratory studies on associations between disease resistance and susceptibility and major histocompatibility (MH) genes in Atlantic salmon Salmo salar have shown the importance of immunogenetics in understanding the capacity of populations to fight specific diseases. However, the occurrence and vir...
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Online Access: | http://hdl.handle.net/10468/5712 https://doi.org/10.1111/j.1752-4571.2011.00197.x |
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ftunivcollcork:oai:cora.ucc.ie:10468/5712 2023-08-27T04:08:29+02:00 Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water de Eyto, Elvira McGinnity, Philip Huisman, Jisca Coughlan, Jamie P. Consuegra, Sofia Farrell, Killian O'Toole, Ciar Tufto, Jarle Megens, Hendrik-Jan Jordan, William Cross, Thomas F. Stet, René J. M. 2011-07-04 application/pdf application/vnd.ms-excel http://hdl.handle.net/10468/5712 https://doi.org/10.1111/j.1752-4571.2011.00197.x en eng John Wiley & Sons Ltd. de Eyto, E., McGinnity, P., Huisman, J., Coughlan, J., Consuegra, S., Farrell, K., O'Toole, C., Tufto, J., Megens, H.-J., Jordan, W., Cross, T. and Stet, R. J. M. (2011) 'Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water', Evolutionary Applications, 4(6), pp. 749-762. doi:10.1111/j.1752-4571.2011.00197.x doi:10.1111/j.1752-4571.2011.00197.x 762 1752-4571 1752-4563 6 Evolutionary Applications 749 http://hdl.handle.net/10468/5712 4 © 2011, the Authors. Evolutionary Applications published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ Atlantic salmon Freshwater life stages Major histocompatibility Natural selection Salmo salar Salar L Genetic variation Pathogen resistance Balancing selection Wild populations Local adaptation Climate change Article (peer-reviewed) 2011 ftunivcollcork https://doi.org/10.1111/j.1752-4571.2011.00197.x 2023-08-06T14:29:44Z Laboratory studies on associations between disease resistance and susceptibility and major histocompatibility (MH) genes in Atlantic salmon Salmo salar have shown the importance of immunogenetics in understanding the capacity of populations to fight specific diseases. However, the occurrence and virulence of pathogens may vary spatially and temporally in the wild, making it more complicated to predict the overall effect that MH genes exert on fitness of natural populations and over several life-history stages. Here we show that MH variability is a significant determinant of salmon survival in fresh water, by comparing observed and expected genotype frequencies at MH and control microsatellite loci at parr and migrant stages in the wild. We found that additive allelic effects at immunogenetic loci were more likely to determine survival than dominance deviation, and that selection on certain MH alleles varied with life stage, possibly owing to varying pathogen prevalence and/or virulence over time. Our results highlight the importance of preserving genetic diversity (particularly at MH loci) in wild populations, so that they have the best chance of adapting to new and increased disease challenges as a result of projected climate warming and increasing aquaculture. Article in Journal/Newspaper Atlantic salmon Salmo salar University College Cork, Ireland: Cork Open Research Archive (CORA) Evolutionary Applications 4 6 749 762 |
institution |
Open Polar |
collection |
University College Cork, Ireland: Cork Open Research Archive (CORA) |
op_collection_id |
ftunivcollcork |
language |
English |
topic |
Atlantic salmon Freshwater life stages Major histocompatibility Natural selection Salmo salar Salar L Genetic variation Pathogen resistance Balancing selection Wild populations Local adaptation Climate change |
spellingShingle |
Atlantic salmon Freshwater life stages Major histocompatibility Natural selection Salmo salar Salar L Genetic variation Pathogen resistance Balancing selection Wild populations Local adaptation Climate change de Eyto, Elvira McGinnity, Philip Huisman, Jisca Coughlan, Jamie P. Consuegra, Sofia Farrell, Killian O'Toole, Ciar Tufto, Jarle Megens, Hendrik-Jan Jordan, William Cross, Thomas F. Stet, René J. M. Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water |
topic_facet |
Atlantic salmon Freshwater life stages Major histocompatibility Natural selection Salmo salar Salar L Genetic variation Pathogen resistance Balancing selection Wild populations Local adaptation Climate change |
description |
Laboratory studies on associations between disease resistance and susceptibility and major histocompatibility (MH) genes in Atlantic salmon Salmo salar have shown the importance of immunogenetics in understanding the capacity of populations to fight specific diseases. However, the occurrence and virulence of pathogens may vary spatially and temporally in the wild, making it more complicated to predict the overall effect that MH genes exert on fitness of natural populations and over several life-history stages. Here we show that MH variability is a significant determinant of salmon survival in fresh water, by comparing observed and expected genotype frequencies at MH and control microsatellite loci at parr and migrant stages in the wild. We found that additive allelic effects at immunogenetic loci were more likely to determine survival than dominance deviation, and that selection on certain MH alleles varied with life stage, possibly owing to varying pathogen prevalence and/or virulence over time. Our results highlight the importance of preserving genetic diversity (particularly at MH loci) in wild populations, so that they have the best chance of adapting to new and increased disease challenges as a result of projected climate warming and increasing aquaculture. |
format |
Article in Journal/Newspaper |
author |
de Eyto, Elvira McGinnity, Philip Huisman, Jisca Coughlan, Jamie P. Consuegra, Sofia Farrell, Killian O'Toole, Ciar Tufto, Jarle Megens, Hendrik-Jan Jordan, William Cross, Thomas F. Stet, René J. M. |
author_facet |
de Eyto, Elvira McGinnity, Philip Huisman, Jisca Coughlan, Jamie P. Consuegra, Sofia Farrell, Killian O'Toole, Ciar Tufto, Jarle Megens, Hendrik-Jan Jordan, William Cross, Thomas F. Stet, René J. M. |
author_sort |
de Eyto, Elvira |
title |
Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water |
title_short |
Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water |
title_full |
Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water |
title_fullStr |
Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water |
title_full_unstemmed |
Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water |
title_sort |
varying disease-mediated selection at different life-history stages of atlantic salmon in fresh water |
publisher |
John Wiley & Sons Ltd. |
publishDate |
2011 |
url |
http://hdl.handle.net/10468/5712 https://doi.org/10.1111/j.1752-4571.2011.00197.x |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
de Eyto, E., McGinnity, P., Huisman, J., Coughlan, J., Consuegra, S., Farrell, K., O'Toole, C., Tufto, J., Megens, H.-J., Jordan, W., Cross, T. and Stet, R. J. M. (2011) 'Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water', Evolutionary Applications, 4(6), pp. 749-762. doi:10.1111/j.1752-4571.2011.00197.x doi:10.1111/j.1752-4571.2011.00197.x 762 1752-4571 1752-4563 6 Evolutionary Applications 749 http://hdl.handle.net/10468/5712 4 |
op_rights |
© 2011, the Authors. Evolutionary Applications published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1111/j.1752-4571.2011.00197.x |
container_title |
Evolutionary Applications |
container_volume |
4 |
container_issue |
6 |
container_start_page |
749 |
op_container_end_page |
762 |
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1775349291540283392 |