C3-epimerization of 25-hydroxyvitamin D increases with increasing serum 25-hydroxyvitamin D levels and shows a high degree of tracking over time

• Published in: Clinical Biochemistry
• Main Authors: Kubiak, Julia M., Grimnes, Guri, Cashman, Kevin D., Kamycheva, Elena, Dowling, Kirsten G., Skrabáková, Zuzana, Jorde, Rolf
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2018
• Subjects: Vitamin D; Epimerization effects; Vitamin D binding protein (DBP); Calcium metabolism; Tromsø; Rho
• Online Access: http://hdl.handle.net/10468/5547; https://doi.org/10.1016/j.clinbiochem.2018.02.013

Objective: Evaluate the effects of serum 25-hydroxyvitamin D (25(OH)D) levels, vitamin D binding protein (DBP) and genetic factors on C3-epimerization of 25(OH)D and follow the tracking of the epimer during one year. Design: Cross-sectional and longitudinal study. Methods: Data from eight previously...