The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis
The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2−4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrome...
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American Chemical Society (ACS)
2011
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Online Access: | https://clok.uclan.ac.uk/20866/ https://doi.org/10.1021/np100499c |
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ftunivclancas:oai:clok.uclan.ac.uk:20866 2023-05-15T14:26:15+02:00 The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis Tadesse, Margey Tabudravu, Jioji Jaspars, Marcel Strøm, Morten B. Hansen, Espen Andersen, Jeanette H. Kristiansen, Per E. Haug, Tor 2011-04-25 https://clok.uclan.ac.uk/20866/ https://doi.org/10.1021/np100499c unknown American Chemical Society (ACS) Tadesse, Margey, Tabudravu, Jioji orcid iconorcid:0000-0002-6930-6572 , Jaspars, Marcel, Strøm, Morten B., Hansen, Espen, Andersen, Jeanette H., Kristiansen, Per E. and Haug, Tor (2011) The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis. Journal of Natural Products, 74 (4). pp. 837-841. ISSN 0163-3864 doi:10.1021/np100499c Bio-organic chemistry Article PeerReviewed 2011 ftunivclancas https://doi.org/10.1021/np100499c 2023-02-23T23:22:56Z The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2−4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1−4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line. Article in Journal/Newspaper Arctic Arctic University of Central Lancashire: CLOK - Central Lancashire Online Knowledge Arctic Journal of Natural Products 74 4 837 841 |
institution |
Open Polar |
collection |
University of Central Lancashire: CLOK - Central Lancashire Online Knowledge |
op_collection_id |
ftunivclancas |
language |
unknown |
topic |
Bio-organic chemistry |
spellingShingle |
Bio-organic chemistry Tadesse, Margey Tabudravu, Jioji Jaspars, Marcel Strøm, Morten B. Hansen, Espen Andersen, Jeanette H. Kristiansen, Per E. Haug, Tor The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis |
topic_facet |
Bio-organic chemistry |
description |
The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2−4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1−4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line. |
format |
Article in Journal/Newspaper |
author |
Tadesse, Margey Tabudravu, Jioji Jaspars, Marcel Strøm, Morten B. Hansen, Espen Andersen, Jeanette H. Kristiansen, Per E. Haug, Tor |
author_facet |
Tadesse, Margey Tabudravu, Jioji Jaspars, Marcel Strøm, Morten B. Hansen, Espen Andersen, Jeanette H. Kristiansen, Per E. Haug, Tor |
author_sort |
Tadesse, Margey |
title |
The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis |
title_short |
The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis |
title_full |
The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis |
title_fullStr |
The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis |
title_full_unstemmed |
The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis |
title_sort |
antibacterial ent-eusynstyelamide b and eusynstyelamides d, e, and f from the arctic bryozoantegella cf. spitzbergensis |
publisher |
American Chemical Society (ACS) |
publishDate |
2011 |
url |
https://clok.uclan.ac.uk/20866/ https://doi.org/10.1021/np100499c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Arctic |
genre_facet |
Arctic Arctic |
op_relation |
Tadesse, Margey, Tabudravu, Jioji orcid iconorcid:0000-0002-6930-6572 , Jaspars, Marcel, Strøm, Morten B., Hansen, Espen, Andersen, Jeanette H., Kristiansen, Per E. and Haug, Tor (2011) The Antibacterial ent-Eusynstyelamide B and Eusynstyelamides D, E, and F from the Arctic BryozoanTegella cf. spitzbergensis. Journal of Natural Products, 74 (4). pp. 837-841. ISSN 0163-3864 doi:10.1021/np100499c |
op_doi |
https://doi.org/10.1021/np100499c |
container_title |
Journal of Natural Products |
container_volume |
74 |
container_issue |
4 |
container_start_page |
837 |
op_container_end_page |
841 |
_version_ |
1766298720421281792 |