The fumarprotocetraric acid inhibits tau covalently, avoiding cytotoxicity of aggregates in cells

• Published in: Molecules
• Main Authors: González, Camila, Cartagena, Constanza, Caballero, Leonardo, Melo, Francisco, Areche Medina, Carlos Alberto, Cornejo, Alberto
• Format: Article in Journal/Newspaper
• Language: English
• Published: MDPI 2021
• Subjects: Lichens; Tauopathies; Alpha,beta carbonyl group; Inhibitors; Aggregates; Cytotoxicity; Antarctic; Inach; Antarc*; antartic*; Instituto Antartico Chileno
• Online Access: https://doi.org/10.3390/molecules26123760; https://repositorio.uchile.cl/handle/2250/182873

Neurodegenerative disorders, including Tauopathies that involve tau protein, base their pathological mechanism on forming proteinaceous aggregates, which has a deleterious effect on cells triggering an inflammatory response. Moreover, tau inhibitors can exert their mechanism of action through noncov...