Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor

• Published in: Natural Product Research
• Main Authors: Salgado, Francisco, Caballero, Julio, Vargas, Reinaldo, Cornejo, Alberto, Areche, Carlos
• Format: Article in Journal/Newspaper
• Language: English
• Published: Taylor & Francis 2020
• Subjects: Alzheimer's disease; Tau protein; Lichens; Antarctic; Inach; The Antarctic; Antarc*; Antarctica
• Online Access: https://doi.org/10.1080/14786419.2018.1492576; https://repositorio.uchile.cl/handle/2250/174423

Alzheimer s disease (AD) is the most common form of dementia involving Ab and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate target, besides tau is also included in other neurodegenerative disorders na...