Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor
Alzheimer s disease (AD) is the most common form of dementia involving Ab and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate target, besides tau is also included in other neurodegenerative disorders na...
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ftunivchile:oai:repositorio.uchile.cl:2250/174423 2023-05-15T13:42:08+02:00 Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor Salgado, Francisco Caballero, Julio Vargas, Reinaldo Cornejo, Alberto Areche, Carlos 2020 application/pdf https://doi.org/10.1080/14786419.2018.1492576 https://repositorio.uchile.cl/handle/2250/174423 en eng Taylor & Francis Natural Product Research 2020, Vol. 34, No. 5, 646–650 doi:10.1080/14786419.2018.1492576 https://repositorio.uchile.cl/handle/2250/174423 Attribution-NonCommercial-NoDerivs 3.0 Chile http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ Natural Product Research Alzheimer's disease Tau protein Lichens Artículo de revista 2020 ftunivchile https://doi.org/10.1080/14786419.2018.1492576 2023-03-12T00:51:01Z Alzheimer s disease (AD) is the most common form of dementia involving Ab and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate target, besides tau is also included in other neurodegenerative disorders named as tauopathies. Here, we have isolated seventeen compounds belonging to six lichens species. Due to scarce of spectroscopic data of the compound 5,7-dihydroxy-6-methylphthalide, we explained their structural elucidation based on NMR data. In this study, we show that only tenuiorin from Umbilicaria antarctica inhibited 50% of tau 4R at 100mM. Then, we shown that molecular interactions of tenuiorin with the steric zipper model of the hexapeptide 306VQIVYK311 were studied by docking calculations and the results suggested that tenuiorin forms both hydrogen bonds with lysine and glutamine side chains and forms several hydrophobic interactions with valine and lysine from 306VQIVYK311 motif. Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1150745 INACH RT 13-13 MT 03-14 Fondo Nacional de Desarrollo Cientifico and Tecnologico Article in Journal/Newspaper Antarc* Antarctic Antarctica Universidad de Chile: Repositorio académico Antarctic Inach ENVELOPE(-60.783,-60.783,-62.467,-62.467) The Antarctic Natural Product Research 34 5 646 650 |
institution |
Open Polar |
collection |
Universidad de Chile: Repositorio académico |
op_collection_id |
ftunivchile |
language |
English |
topic |
Alzheimer's disease Tau protein Lichens |
spellingShingle |
Alzheimer's disease Tau protein Lichens Salgado, Francisco Caballero, Julio Vargas, Reinaldo Cornejo, Alberto Areche, Carlos Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
topic_facet |
Alzheimer's disease Tau protein Lichens |
description |
Alzheimer s disease (AD) is the most common form of dementia involving Ab and tau protein. So far, AD cure remains elusive, but considering that AD progresses throughout tau pathology, which turns tau protein an appropriate target, besides tau is also included in other neurodegenerative disorders named as tauopathies. Here, we have isolated seventeen compounds belonging to six lichens species. Due to scarce of spectroscopic data of the compound 5,7-dihydroxy-6-methylphthalide, we explained their structural elucidation based on NMR data. In this study, we show that only tenuiorin from Umbilicaria antarctica inhibited 50% of tau 4R at 100mM. Then, we shown that molecular interactions of tenuiorin with the steric zipper model of the hexapeptide 306VQIVYK311 were studied by docking calculations and the results suggested that tenuiorin forms both hydrogen bonds with lysine and glutamine side chains and forms several hydrophobic interactions with valine and lysine from 306VQIVYK311 motif. Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1150745 INACH RT 13-13 MT 03-14 Fondo Nacional de Desarrollo Cientifico and Tecnologico |
format |
Article in Journal/Newspaper |
author |
Salgado, Francisco Caballero, Julio Vargas, Reinaldo Cornejo, Alberto Areche, Carlos |
author_facet |
Salgado, Francisco Caballero, Julio Vargas, Reinaldo Cornejo, Alberto Areche, Carlos |
author_sort |
Salgado, Francisco |
title |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_short |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_full |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_fullStr |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_full_unstemmed |
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor |
title_sort |
continental and antarctic lichens: isolation, identification and molecular modeling of the depside tenuiorin from the antarctic lichen umbilicaria antarctica as tau protein inhibitor |
publisher |
Taylor & Francis |
publishDate |
2020 |
url |
https://doi.org/10.1080/14786419.2018.1492576 https://repositorio.uchile.cl/handle/2250/174423 |
long_lat |
ENVELOPE(-60.783,-60.783,-62.467,-62.467) |
geographic |
Antarctic Inach The Antarctic |
geographic_facet |
Antarctic Inach The Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
Natural Product Research |
op_relation |
Natural Product Research 2020, Vol. 34, No. 5, 646–650 doi:10.1080/14786419.2018.1492576 https://repositorio.uchile.cl/handle/2250/174423 |
op_rights |
Attribution-NonCommercial-NoDerivs 3.0 Chile http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ |
op_doi |
https://doi.org/10.1080/14786419.2018.1492576 |
container_title |
Natural Product Research |
container_volume |
34 |
container_issue |
5 |
container_start_page |
646 |
op_container_end_page |
650 |
_version_ |
1766162957443530752 |