Bayesian genome wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.)
We performed a genome-wide association study to detect markers associated with growth traits in Atlantic salmon. The analyzed traits included body weight at tagging (BWT) and body weight at 25 months (BW25M). Genotypes of 4662 animals were imputed from the 50K SNP chip to the 200K SNP chip using FIM...
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Online Access: | https://doi.org/10.1111/age.12621 https://repositorio.uchile.cl/handle/2250/148911 |
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ftunivchile:oai:repositorio.uchile.cl:2250/148911 2023-05-15T15:31:03+02:00 Bayesian genome wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.) Yoshida, Grazyella Massako Lhorente, Jean Paul Carvalheiro, Roberto Yáñez López, José 2017 application/pdf https://doi.org/10.1111/age.12621 https://repositorio.uchile.cl/handle/2250/148911 en eng Wiley Animal Genetics Vol. 48 (6): 698-703 doi:10.1111/age.12621 https://repositorio.uchile.cl/handle/2250/148911 Attribution-NonCommercial-NoDerivs 3.0 Chile http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ CC-BY-NC-ND Animal Genetics Bayes C Growth Imputation Myosin Single nucleotide polymorphism Artículo de revista 2017 ftunivchile https://doi.org/10.1111/age.12621 2023-01-29T00:55:35Z We performed a genome-wide association study to detect markers associated with growth traits in Atlantic salmon. The analyzed traits included body weight at tagging (BWT) and body weight at 25 months (BW25M). Genotypes of 4662 animals were imputed from the 50K SNP chip to the 200K SNP chip using FIMPUTE software. The markers were simultaneously modeled using Bayes C to identify genomic regions associated with the traits. We identified windows explaining a maximum of 3.71% and 3.61% of the genetic variance for BWT and BW25M respectively. We found potential candidate genes located within the top ten 1-Mb windows for BWT and BW25M. For instance, the vitronectin (VTN) gene, which has been previously reported to be associated with cell growth, was found within one of the top ten 1-Mb windows for BWT. In addition, the WNT1-inducible-signaling pathway protein 3, melanocortin 2 receptor accessory protein 2, myosin light chain kinase, transforming growth factor beta receptor type 3 and myosin light chain 1 genes, which have been reported to be associated with skeletal growth in humans, growth stimulation during the larval stage in zebrafish, body weight in pigs, feed conversion in chickens and growth rate of sheep skeletal muscle respectively, were found within some of the top ten 1-Mb windows for BW25M. These results indicate that growth traits are most likely controlled by many variants with relatively small effects in Atlantic salmon. The genomic regions associated with the traits studied here may provide further insight into the functional regions underlying growth traits in this species. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) 2014/20626-4 2015/25232-7 CNPq 308636/2014-7 Article in Journal/Newspaper Atlantic salmon Salmo salar Universidad de Chile: Repositorio académico Animal Genetics 48 6 698 703 |
institution |
Open Polar |
collection |
Universidad de Chile: Repositorio académico |
op_collection_id |
ftunivchile |
language |
English |
topic |
Bayes C Growth Imputation Myosin Single nucleotide polymorphism |
spellingShingle |
Bayes C Growth Imputation Myosin Single nucleotide polymorphism Yoshida, Grazyella Massako Lhorente, Jean Paul Carvalheiro, Roberto Yáñez López, José Bayesian genome wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.) |
topic_facet |
Bayes C Growth Imputation Myosin Single nucleotide polymorphism |
description |
We performed a genome-wide association study to detect markers associated with growth traits in Atlantic salmon. The analyzed traits included body weight at tagging (BWT) and body weight at 25 months (BW25M). Genotypes of 4662 animals were imputed from the 50K SNP chip to the 200K SNP chip using FIMPUTE software. The markers were simultaneously modeled using Bayes C to identify genomic regions associated with the traits. We identified windows explaining a maximum of 3.71% and 3.61% of the genetic variance for BWT and BW25M respectively. We found potential candidate genes located within the top ten 1-Mb windows for BWT and BW25M. For instance, the vitronectin (VTN) gene, which has been previously reported to be associated with cell growth, was found within one of the top ten 1-Mb windows for BWT. In addition, the WNT1-inducible-signaling pathway protein 3, melanocortin 2 receptor accessory protein 2, myosin light chain kinase, transforming growth factor beta receptor type 3 and myosin light chain 1 genes, which have been reported to be associated with skeletal growth in humans, growth stimulation during the larval stage in zebrafish, body weight in pigs, feed conversion in chickens and growth rate of sheep skeletal muscle respectively, were found within some of the top ten 1-Mb windows for BW25M. These results indicate that growth traits are most likely controlled by many variants with relatively small effects in Atlantic salmon. The genomic regions associated with the traits studied here may provide further insight into the functional regions underlying growth traits in this species. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) 2014/20626-4 2015/25232-7 CNPq 308636/2014-7 |
format |
Article in Journal/Newspaper |
author |
Yoshida, Grazyella Massako Lhorente, Jean Paul Carvalheiro, Roberto Yáñez López, José |
author_facet |
Yoshida, Grazyella Massako Lhorente, Jean Paul Carvalheiro, Roberto Yáñez López, José |
author_sort |
Yoshida, Grazyella Massako |
title |
Bayesian genome wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.) |
title_short |
Bayesian genome wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.) |
title_full |
Bayesian genome wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.) |
title_fullStr |
Bayesian genome wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.) |
title_full_unstemmed |
Bayesian genome wide association analysis for body weight in farmed Atlantic salmon (Salmo salar L.) |
title_sort |
bayesian genome wide association analysis for body weight in farmed atlantic salmon (salmo salar l.) |
publisher |
Wiley |
publishDate |
2017 |
url |
https://doi.org/10.1111/age.12621 https://repositorio.uchile.cl/handle/2250/148911 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Animal Genetics |
op_relation |
Animal Genetics Vol. 48 (6): 698-703 doi:10.1111/age.12621 https://repositorio.uchile.cl/handle/2250/148911 |
op_rights |
Attribution-NonCommercial-NoDerivs 3.0 Chile http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1111/age.12621 |
container_title |
Animal Genetics |
container_volume |
48 |
container_issue |
6 |
container_start_page |
698 |
op_container_end_page |
703 |
_version_ |
1766361547843567616 |