Pros and cons of methylation-based enrichment methods for ancient DNA

• Published in: Scientific Reports
• Main Authors: Seguin Orlando, Andaine, Gamba, Cristina, Sarkissian, Clio Der, Ermini, Luca, Louvel, Guillaume, Boulygina, Eugenia, Sokolov, Alexey, Nedoluzhko, Artem, Lorenzen, Eline D., López, Patricio, McDonald, H. Gregory, Scott, Eric, Tikhonov, Alexei, Stafford, Thomas W., Alfarhan, Ahmed H., Alquraishi, Saleh A., Al-Rasheid, Khaled A. S., Shapiro, Beth, Willerslev, Eske, Prokhortchouk, Egor, Orlando, Ludovic
• Format: Article in Journal/Newspaper
• Language: English
• Published: Nature Publishing 2015
• Subjects: Complete mitochondrial genome; Sequencing libraries; CPG islands; Horse; Capture; Reveal; Polar; Amplification; Evolutionary; Neanderthal; Isi; eskimo*; Saqqaq
• Online Access: https://doi.org/10.1038/srep11826; https://repositorio.uchile.cl/handle/2250/133888

Artículo de publicación ISI The recent discovery that DNA methylation survives in fossil material provides an opportunity for novel molecular approaches in palaeogenomics. Here, we apply to ancient DNA extracts the probe-independent Methylated Binding Domains (MBD)-based enrichment method, which tar...