Localisation of a susceptibility locus for schizophrenia on chromosome 5
"A considerable proportion of the variance in the liability to develop schizophrenia may be genetic, but segregation analysis, to establish a mode of transmission, has not produced a consistent result. One of these studies was carried out in Iceland and made use of the large family size and ext...
Published in: | British Journal of Psychiatry |
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Royal College of Psychiatrists
1990
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Online Access: | https://orca.cardiff.ac.uk/id/eprint/81091/ https://doi.org/10.1192/bjp.157.1.123 |
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ftunivcardiff:oai:https://orca.cardiff.ac.uk:81091 2023-05-15T16:49:23+02:00 Localisation of a susceptibility locus for schizophrenia on chromosome 5 Owen, Michael John Craufurd, D. St Clair, D. 1990-07 https://orca.cardiff.ac.uk/id/eprint/81091/ https://doi.org/10.1192/bjp.157.1.123 unknown Royal College of Psychiatrists Owen, Michael John https://orca.cardiff.ac.uk/view/cardiffauthors/A069868J.html orcid:0000-0003-4798-0862 orcid:0000-0003-4798-0862, Craufurd, D. and St Clair, D. 1990. Localisation of a susceptibility locus for schizophrenia on chromosome 5. British Journal of Psychiatry 157 (1) , pp. 123-127. 10.1192/bjp.157.1.123 https://doi.org/10.1192/bjp.157.1.123 doi:10.1192/bjp.157.1.123 R Medicine (General) Article PeerReviewed 1990 ftunivcardiff https://doi.org/10.1192/bjp.157.1.123 2022-11-03T23:35:35Z "A considerable proportion of the variance in the liability to develop schizophrenia may be genetic, but segregation analysis, to establish a mode of transmission, has not produced a consistent result. One of these studies was carried out in Iceland and made use of the large family size and extensive genealogical information present in that country. Here we demonstrate genetic linkage of two DNA polymorphisms on the long arm of human chromosome 5 to schizophrenia in seven British and Icelandic families with multiple affected members. The results indicate the existence of a gene locus with a dominant schizophrenia-susceptibility allele. Inheritance of the allele in the families studied suggests that it may also predispose to psychiatric conditions such as schizophrenia spectrum disorders and a variety of other disorders. This report provides the first strong evidence for the involvement of a single gene in the causation of schizophrenia." Article in Journal/Newspaper Iceland Cardiff University: ORCA (Online Research @ Cardiff) Long Arm ENVELOPE(-55.648,-55.648,49.517,49.517) British Journal of Psychiatry 157 1 123 127 |
institution |
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Cardiff University: ORCA (Online Research @ Cardiff) |
op_collection_id |
ftunivcardiff |
language |
unknown |
topic |
R Medicine (General) |
spellingShingle |
R Medicine (General) Owen, Michael John Craufurd, D. St Clair, D. Localisation of a susceptibility locus for schizophrenia on chromosome 5 |
topic_facet |
R Medicine (General) |
description |
"A considerable proportion of the variance in the liability to develop schizophrenia may be genetic, but segregation analysis, to establish a mode of transmission, has not produced a consistent result. One of these studies was carried out in Iceland and made use of the large family size and extensive genealogical information present in that country. Here we demonstrate genetic linkage of two DNA polymorphisms on the long arm of human chromosome 5 to schizophrenia in seven British and Icelandic families with multiple affected members. The results indicate the existence of a gene locus with a dominant schizophrenia-susceptibility allele. Inheritance of the allele in the families studied suggests that it may also predispose to psychiatric conditions such as schizophrenia spectrum disorders and a variety of other disorders. This report provides the first strong evidence for the involvement of a single gene in the causation of schizophrenia." |
format |
Article in Journal/Newspaper |
author |
Owen, Michael John Craufurd, D. St Clair, D. |
author_facet |
Owen, Michael John Craufurd, D. St Clair, D. |
author_sort |
Owen, Michael John |
title |
Localisation of a susceptibility locus for schizophrenia on chromosome 5 |
title_short |
Localisation of a susceptibility locus for schizophrenia on chromosome 5 |
title_full |
Localisation of a susceptibility locus for schizophrenia on chromosome 5 |
title_fullStr |
Localisation of a susceptibility locus for schizophrenia on chromosome 5 |
title_full_unstemmed |
Localisation of a susceptibility locus for schizophrenia on chromosome 5 |
title_sort |
localisation of a susceptibility locus for schizophrenia on chromosome 5 |
publisher |
Royal College of Psychiatrists |
publishDate |
1990 |
url |
https://orca.cardiff.ac.uk/id/eprint/81091/ https://doi.org/10.1192/bjp.157.1.123 |
long_lat |
ENVELOPE(-55.648,-55.648,49.517,49.517) |
geographic |
Long Arm |
geographic_facet |
Long Arm |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Owen, Michael John https://orca.cardiff.ac.uk/view/cardiffauthors/A069868J.html orcid:0000-0003-4798-0862 orcid:0000-0003-4798-0862, Craufurd, D. and St Clair, D. 1990. Localisation of a susceptibility locus for schizophrenia on chromosome 5. British Journal of Psychiatry 157 (1) , pp. 123-127. 10.1192/bjp.157.1.123 https://doi.org/10.1192/bjp.157.1.123 doi:10.1192/bjp.157.1.123 |
op_doi |
https://doi.org/10.1192/bjp.157.1.123 |
container_title |
British Journal of Psychiatry |
container_volume |
157 |
container_issue |
1 |
container_start_page |
123 |
op_container_end_page |
127 |
_version_ |
1766039535232221184 |