Laterality defect of the heart in non-teleost fish
Dextrocardia is a rare congenital malformation in humans in which most of the heart mass is positioned in the right hemithorax rather than on the left. The heart itself may be normal and dextrocardia is sometimes diagnosed during non-related explorations. A few reports have documented atypical posit...
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ftunivcantabria:oai:repositorio.unican.es:10902/30415 2023-11-12T04:28:22+01:00 Laterality defect of the heart in non-teleost fish Huijskes, Myrte M. Icardo de la Escalera, José Manuel Coolen, Bram F. Jensen, Bjarke Universidad de Cantabria 2023 https://hdl.handle.net/10902/30415 https://doi.org/10.1111/joa.13933 eng eng John Wiley & Sons https://doi.org/10.1111/joa.13933 0021-8782 1469-7580 https://hdl.handle.net/10902/30415 doi:10.1111/joa.13933 Attribution-NonCommercial 4.0 International © 2023 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society http://creativecommons.org/licenses/by-nc/4.0/ openAccess Journal of Anatomy, 2023, 00, 1-7 Atrioventricular canal MRI Shark Sturgeon info:eu-repo/semantics/article publishedVersion 2023 ftunivcantabria https://doi.org/10.1111/joa.13933 2023-11-01T00:18:14Z Dextrocardia is a rare congenital malformation in humans in which most of the heart mass is positioned in the right hemithorax rather than on the left. The heart itself may be normal and dextrocardia is sometimes diagnosed during non-related explorations. A few reports have documented atypical positions of the cardiac chambers in farmed teleost fish. Here, we report the casual finding of a left-right mirrored heart in an 85 cm long wild-caught spiny dogfish (Squalus acanthias) with several organ malformations. Macroscopic observations showed an outflow tract originating from the left side of the ventricular mass, rather than from the right. Internal inspection revealed the expected structures and a looped cavity. The inner curvature of the loop comprised a large trabeculation, the bulboventricular fold, as expected. The junction between the sinus venosus and the atrium appeared normal, only mirrored. MRI data acquired at 0.7 mm isotropic resolution and subsequent 3D-modeling revealed the atrioventricular canal was to the right of the bulboventricular fold, rather than on the left. Spurred by the finding of dextrocardia in the shark, we revisit our previously published material on farmed Adriatic sturgeon (Acipenser naccarii), a non-teleost bony fish. We found several alevins with inverted (left-loop) hearts, amounting to an approximate incidence of 1%-2%. Additionally, an adult sturgeon measuring 90 cm in length showed abnormal topology of the cardiac chambers, but normal position of the abdominal organs. In conclusion, left-right mirrored hearts, a setting that resembles human dextrocardia, can occur in both farmed and wild non-teleost fish. ACKNOWLEDGMENTS. The authors wish to thank A. Domezain, from the Sierra Nevada Fishery at Riofrío, Granada, Spain, for generous access to the sturgeon material. Jaco Hagoort's help in generating the 3D model is much appreciated Article in Journal/Newspaper spiny dogfish Squalus acanthias Universidad de Cantabria: UCrea |
institution |
Open Polar |
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Universidad de Cantabria: UCrea |
op_collection_id |
ftunivcantabria |
language |
English |
topic |
Atrioventricular canal MRI Shark Sturgeon |
spellingShingle |
Atrioventricular canal MRI Shark Sturgeon Huijskes, Myrte M. Icardo de la Escalera, José Manuel Coolen, Bram F. Jensen, Bjarke Laterality defect of the heart in non-teleost fish |
topic_facet |
Atrioventricular canal MRI Shark Sturgeon |
description |
Dextrocardia is a rare congenital malformation in humans in which most of the heart mass is positioned in the right hemithorax rather than on the left. The heart itself may be normal and dextrocardia is sometimes diagnosed during non-related explorations. A few reports have documented atypical positions of the cardiac chambers in farmed teleost fish. Here, we report the casual finding of a left-right mirrored heart in an 85 cm long wild-caught spiny dogfish (Squalus acanthias) with several organ malformations. Macroscopic observations showed an outflow tract originating from the left side of the ventricular mass, rather than from the right. Internal inspection revealed the expected structures and a looped cavity. The inner curvature of the loop comprised a large trabeculation, the bulboventricular fold, as expected. The junction between the sinus venosus and the atrium appeared normal, only mirrored. MRI data acquired at 0.7 mm isotropic resolution and subsequent 3D-modeling revealed the atrioventricular canal was to the right of the bulboventricular fold, rather than on the left. Spurred by the finding of dextrocardia in the shark, we revisit our previously published material on farmed Adriatic sturgeon (Acipenser naccarii), a non-teleost bony fish. We found several alevins with inverted (left-loop) hearts, amounting to an approximate incidence of 1%-2%. Additionally, an adult sturgeon measuring 90 cm in length showed abnormal topology of the cardiac chambers, but normal position of the abdominal organs. In conclusion, left-right mirrored hearts, a setting that resembles human dextrocardia, can occur in both farmed and wild non-teleost fish. ACKNOWLEDGMENTS. The authors wish to thank A. Domezain, from the Sierra Nevada Fishery at Riofrío, Granada, Spain, for generous access to the sturgeon material. Jaco Hagoort's help in generating the 3D model is much appreciated |
author2 |
Universidad de Cantabria |
format |
Article in Journal/Newspaper |
author |
Huijskes, Myrte M. Icardo de la Escalera, José Manuel Coolen, Bram F. Jensen, Bjarke |
author_facet |
Huijskes, Myrte M. Icardo de la Escalera, José Manuel Coolen, Bram F. Jensen, Bjarke |
author_sort |
Huijskes, Myrte M. |
title |
Laterality defect of the heart in non-teleost fish |
title_short |
Laterality defect of the heart in non-teleost fish |
title_full |
Laterality defect of the heart in non-teleost fish |
title_fullStr |
Laterality defect of the heart in non-teleost fish |
title_full_unstemmed |
Laterality defect of the heart in non-teleost fish |
title_sort |
laterality defect of the heart in non-teleost fish |
publisher |
John Wiley & Sons |
publishDate |
2023 |
url |
https://hdl.handle.net/10902/30415 https://doi.org/10.1111/joa.13933 |
genre |
spiny dogfish Squalus acanthias |
genre_facet |
spiny dogfish Squalus acanthias |
op_source |
Journal of Anatomy, 2023, 00, 1-7 |
op_relation |
https://doi.org/10.1111/joa.13933 0021-8782 1469-7580 https://hdl.handle.net/10902/30415 doi:10.1111/joa.13933 |
op_rights |
Attribution-NonCommercial 4.0 International © 2023 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society http://creativecommons.org/licenses/by-nc/4.0/ openAccess |
op_doi |
https://doi.org/10.1111/joa.13933 |
_version_ |
1782341575673643008 |