Helicobacter pylori's historical journey through Siberia and the Americas.
The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human...
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Proceedings of the National Academy of Sciences
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ftunivcam:oai:www.repository.cam.ac.uk:1810/330521 2024-02-04T09:59:18+01:00 Helicobacter pylori's historical journey through Siberia and the Americas. Moodley, Yoshan Brunelli, Andrea Ghirotto, Silvia Klyubin, Andrey Maady, Ayas S Tyne, William Muñoz-Ramirez, Zilia Y Zhou, Zhemin Manica, Andrea Linz, Bodo Achtman, Mark 2021-06-22 Print application/pdf https://www.repository.cam.ac.uk/handle/1810/330521 https://doi.org/10.17863/CAM.77964 eng eng Proceedings of the National Academy of Sciences http://dx.doi.org/10.1073/pnas.2015523118 Proc Natl Acad Sci U S A https://www.repository.cam.ac.uk/handle/1810/330521 doi:10.17863/CAM.77964 Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ Americas Helicobacter pylori Siberia colonization demographic model Animal Migration Biological Evolution Genome Bacterial Geography Humans Models Biological Multilocus Sequence Typing Article 2021 ftunivcam https://doi.org/10.17863/CAM.77964 2024-01-11T23:19:11Z The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human populations across Siberia to help resolve whether ancient northern Eurasian populations persisted at high latitudes through the last glacial maximum and the relationships between present-day Siberians and Native Americans. A total of 556 strains were cultivated and genotyped by multilocus sequence typing, and 54 representative draft genomes were sequenced. The genetic diversity across Eurasia and the Americas was structured into three populations: hpAsia2, hpEastAsia, and hpNorthAsia. hpNorthAsia is closely related to the subpopulation hspIndigenousAmericas from Native Americans. Siberian bacteria were structured into five other subpopulations, two of which evolved through a divergence from hpAsia2 and hpNorthAsia, while three originated though Holocene admixture. The presence of both anciently diverged and recently admixed strains across Siberia support both Pleistocene persistence and Holocene recolonization. We also show that hspIndigenousAmericas is endemic in human populations across northern Eurasia. The evolutionary history of hspIndigenousAmericas was reconstructed using approximate Bayesian computation, which showed that it colonized the New World in a single migration event associated with a severe demographic bottleneck followed by low levels of recent admixture across the Bering Strait. Article in Journal/Newspaper Bering Strait Siberia Apollo - University of Cambridge Repository Bering Strait |
institution |
Open Polar |
collection |
Apollo - University of Cambridge Repository |
op_collection_id |
ftunivcam |
language |
English |
topic |
Americas Helicobacter pylori Siberia colonization demographic model Animal Migration Biological Evolution Genome Bacterial Geography Humans Models Biological Multilocus Sequence Typing |
spellingShingle |
Americas Helicobacter pylori Siberia colonization demographic model Animal Migration Biological Evolution Genome Bacterial Geography Humans Models Biological Multilocus Sequence Typing Moodley, Yoshan Brunelli, Andrea Ghirotto, Silvia Klyubin, Andrey Maady, Ayas S Tyne, William Muñoz-Ramirez, Zilia Y Zhou, Zhemin Manica, Andrea Linz, Bodo Achtman, Mark Helicobacter pylori's historical journey through Siberia and the Americas. |
topic_facet |
Americas Helicobacter pylori Siberia colonization demographic model Animal Migration Biological Evolution Genome Bacterial Geography Humans Models Biological Multilocus Sequence Typing |
description |
The gastric bacterium Helicobacter pylori shares a coevolutionary history with humans that predates the out-of-Africa diaspora, and the geographical specificities of H. pylori populations reflect multiple well-known human migrations. We extensively sampled H. pylori from 16 ethnically diverse human populations across Siberia to help resolve whether ancient northern Eurasian populations persisted at high latitudes through the last glacial maximum and the relationships between present-day Siberians and Native Americans. A total of 556 strains were cultivated and genotyped by multilocus sequence typing, and 54 representative draft genomes were sequenced. The genetic diversity across Eurasia and the Americas was structured into three populations: hpAsia2, hpEastAsia, and hpNorthAsia. hpNorthAsia is closely related to the subpopulation hspIndigenousAmericas from Native Americans. Siberian bacteria were structured into five other subpopulations, two of which evolved through a divergence from hpAsia2 and hpNorthAsia, while three originated though Holocene admixture. The presence of both anciently diverged and recently admixed strains across Siberia support both Pleistocene persistence and Holocene recolonization. We also show that hspIndigenousAmericas is endemic in human populations across northern Eurasia. The evolutionary history of hspIndigenousAmericas was reconstructed using approximate Bayesian computation, which showed that it colonized the New World in a single migration event associated with a severe demographic bottleneck followed by low levels of recent admixture across the Bering Strait. |
format |
Article in Journal/Newspaper |
author |
Moodley, Yoshan Brunelli, Andrea Ghirotto, Silvia Klyubin, Andrey Maady, Ayas S Tyne, William Muñoz-Ramirez, Zilia Y Zhou, Zhemin Manica, Andrea Linz, Bodo Achtman, Mark |
author_facet |
Moodley, Yoshan Brunelli, Andrea Ghirotto, Silvia Klyubin, Andrey Maady, Ayas S Tyne, William Muñoz-Ramirez, Zilia Y Zhou, Zhemin Manica, Andrea Linz, Bodo Achtman, Mark |
author_sort |
Moodley, Yoshan |
title |
Helicobacter pylori's historical journey through Siberia and the Americas. |
title_short |
Helicobacter pylori's historical journey through Siberia and the Americas. |
title_full |
Helicobacter pylori's historical journey through Siberia and the Americas. |
title_fullStr |
Helicobacter pylori's historical journey through Siberia and the Americas. |
title_full_unstemmed |
Helicobacter pylori's historical journey through Siberia and the Americas. |
title_sort |
helicobacter pylori's historical journey through siberia and the americas. |
publisher |
Proceedings of the National Academy of Sciences |
publishDate |
2021 |
url |
https://www.repository.cam.ac.uk/handle/1810/330521 https://doi.org/10.17863/CAM.77964 |
geographic |
Bering Strait |
geographic_facet |
Bering Strait |
genre |
Bering Strait Siberia |
genre_facet |
Bering Strait Siberia |
op_relation |
https://www.repository.cam.ac.uk/handle/1810/330521 doi:10.17863/CAM.77964 |
op_rights |
Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_doi |
https://doi.org/10.17863/CAM.77964 |
_version_ |
1789964056445059072 |