Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam
Funder: Natural Environment Research Council; doi: http://dx.doi.org/10.13039/501100000270 Funder: Wolfson College, University of Cambridge (GB) Abstract: A computationally predicted gene regulatory network (GRN), generated from mantle-specific gene expression profiles in the Antarctic clam Laternul...
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ftunivcam:oai:www.repository.cam.ac.uk:1810/322751 2023-07-30T03:59:24+02:00 Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam Ramsøe, Abigail Clark, Melody S. Sleight, Victoria A. 2021-05-20T18:04:42Z application/pdf text/xml application/zip https://doi.org/10.17863/CAM.70207 https://www.repository.cam.ac.uk/handle/1810/322751 en eng Springer Netherlands Cell Stress and Chaperones doi:10.17863/CAM.70207 https://www.repository.cam.ac.uk/handle/1810/322751 Short Communication Heat stress Hypoxia Gene duplication Ribosome Signalling Cytoskeleton Other 2021 ftunivcam https://doi.org/10.17863/CAM.70207 2023-07-10T22:07:03Z Funder: Natural Environment Research Council; doi: http://dx.doi.org/10.13039/501100000270 Funder: Wolfson College, University of Cambridge (GB) Abstract: A computationally predicted gene regulatory network (GRN), generated from mantle-specific gene expression profiles in the Antarctic clam Laternula elliptica, was interrogated to test the regulation and interaction of duplicated inducible hsp70 paralogues. hsp70A and hsp70B were identified in the GRN with each paralogue falling into unique submodules that were linked together by a single shared second neighbour. Annotations associated with the clusters in each submodule suggested that hsp70A primarily shares regulatory relationships with genes encoding ribosomal proteins, where it may have a role in protecting the ribosome under stress. hsp70B, on the other hand, interacted with a suite of genes involved in signalling pathways, including four transcription factors, cellular response to stress and the cytoskeleton. Given the contrasting submodules and associated annotations of the two hsp70 paralogues, the GRN analysis suggests that each gene is carrying out additional separate functions, as well as being involved in the traditional chaperone heat stress response, and therefore supports the hypothesis that subfunctionalization has occurred after gene duplication. The GRN was specifically produced from experiments investigating biomineralization; however, this study shows the utility of such data for investigating multiple questions concerning gene duplications, interactions and putative functions in a non-model species. Other/Unknown Material Antarc* Antarctic Apollo - University of Cambridge Repository Antarctic The Antarctic |
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Apollo - University of Cambridge Repository |
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language |
English |
topic |
Short Communication Heat stress Hypoxia Gene duplication Ribosome Signalling Cytoskeleton |
spellingShingle |
Short Communication Heat stress Hypoxia Gene duplication Ribosome Signalling Cytoskeleton Ramsøe, Abigail Clark, Melody S. Sleight, Victoria A. Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam |
topic_facet |
Short Communication Heat stress Hypoxia Gene duplication Ribosome Signalling Cytoskeleton |
description |
Funder: Natural Environment Research Council; doi: http://dx.doi.org/10.13039/501100000270 Funder: Wolfson College, University of Cambridge (GB) Abstract: A computationally predicted gene regulatory network (GRN), generated from mantle-specific gene expression profiles in the Antarctic clam Laternula elliptica, was interrogated to test the regulation and interaction of duplicated inducible hsp70 paralogues. hsp70A and hsp70B were identified in the GRN with each paralogue falling into unique submodules that were linked together by a single shared second neighbour. Annotations associated with the clusters in each submodule suggested that hsp70A primarily shares regulatory relationships with genes encoding ribosomal proteins, where it may have a role in protecting the ribosome under stress. hsp70B, on the other hand, interacted with a suite of genes involved in signalling pathways, including four transcription factors, cellular response to stress and the cytoskeleton. Given the contrasting submodules and associated annotations of the two hsp70 paralogues, the GRN analysis suggests that each gene is carrying out additional separate functions, as well as being involved in the traditional chaperone heat stress response, and therefore supports the hypothesis that subfunctionalization has occurred after gene duplication. The GRN was specifically produced from experiments investigating biomineralization; however, this study shows the utility of such data for investigating multiple questions concerning gene duplications, interactions and putative functions in a non-model species. |
format |
Other/Unknown Material |
author |
Ramsøe, Abigail Clark, Melody S. Sleight, Victoria A. |
author_facet |
Ramsøe, Abigail Clark, Melody S. Sleight, Victoria A. |
author_sort |
Ramsøe, Abigail |
title |
Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam |
title_short |
Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam |
title_full |
Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam |
title_fullStr |
Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam |
title_full_unstemmed |
Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam |
title_sort |
gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the antarctic clam |
publisher |
Springer Netherlands |
publishDate |
2021 |
url |
https://doi.org/10.17863/CAM.70207 https://www.repository.cam.ac.uk/handle/1810/322751 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
doi:10.17863/CAM.70207 https://www.repository.cam.ac.uk/handle/1810/322751 |
op_doi |
https://doi.org/10.17863/CAM.70207 |
_version_ |
1772810216001241088 |