Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder.
BACKGROUND: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed mothers, taking account parental severe mental disorders. METHODS: In the gene...
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ftunivcam:oai:www.repository.cam.ac.uk:1810/289662 2024-02-04T10:03:14+01:00 Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder. Taka-Eilola Nèe Riekki, Tiina Veijola, Juha Murray, Graham K Koskela, Jari Mäki, Pirjo 2019-04-15 Print-Electronic application/vnd.openxmlformats-officedocument.wordprocessingml.document https://www.repository.cam.ac.uk/handle/1810/289662 https://doi.org/10.17863/CAM.36910 eng eng Elsevier BV http://dx.doi.org/10.1016/j.jad.2019.02.011 J Affect Disord https://www.repository.cam.ac.uk/handle/1810/289662 doi:10.17863/CAM.36910 Antenatal Bipolar disorder Depression Mood disorders Parental mental disorder Schizophrenia Adolescent Adult Adult Children Child Child of Impaired Parents Cohort Studies Depressive Disorder Female Finland Follow-Up Studies Humans Mother-Child Relations Mothers Pregnancy Pregnancy Complications Prenatal Diagnosis Schizophrenic Psychology Young Adult Article 2019 ftunivcam https://doi.org/10.17863/CAM.36910 2024-01-11T23:22:06Z BACKGROUND: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed mothers, taking account parental severe mental disorders. METHODS: In the general population-based Northern Finland 1966 Birth Cohort with 12,058 children, 13.9% of the mothers reported themselves depressed at mid-gestation. The offspring were followed 43 years. Severe mood disorders and schizophrenia in the offspring and severe mental disorders in the parents were detected using the Care Register for Healthcare. Maternal smoking during pregnancy, perinatal complications, fathers´ social class, family type at birth, and grand multiparity were considered as confounding variables. RESULTS: The offspring of antenatally depressed mothers had an elevated risk for depression (adjusted OR 1.5; 95% CI 1.03-2.2), compared to cohort members without maternal antenatal depressed mood. The offspring with maternal antenatal depressed mood and parental severe mental disorder had markedly elevated risks for depression (3.3; 1.8-6.2), and schizophrenia (3.9; 2.0-7.5), compared to the offspring without one or both of these risk factors. LIMITATIONS: Maternal antenatal depressed mood was determined by one question and did not necessarily signify a clinical condition. Data on maternal postnatal mood was not available. CONCLUSION: The offspring with maternal antenatal depressed mood and parental severe mental disorder had high risk for depression and schizophrenia. Early interventions in parental severe mental disorder might present an opportunity for decreasing the risk for mood disorders and schizophrenia in the offspring. Article in Journal/Newspaper Northern Finland Apollo - University of Cambridge Repository |
institution |
Open Polar |
collection |
Apollo - University of Cambridge Repository |
op_collection_id |
ftunivcam |
language |
English |
topic |
Antenatal Bipolar disorder Depression Mood disorders Parental mental disorder Schizophrenia Adolescent Adult Adult Children Child Child of Impaired Parents Cohort Studies Depressive Disorder Female Finland Follow-Up Studies Humans Mother-Child Relations Mothers Pregnancy Pregnancy Complications Prenatal Diagnosis Schizophrenic Psychology Young Adult |
spellingShingle |
Antenatal Bipolar disorder Depression Mood disorders Parental mental disorder Schizophrenia Adolescent Adult Adult Children Child Child of Impaired Parents Cohort Studies Depressive Disorder Female Finland Follow-Up Studies Humans Mother-Child Relations Mothers Pregnancy Pregnancy Complications Prenatal Diagnosis Schizophrenic Psychology Young Adult Taka-Eilola Nèe Riekki, Tiina Veijola, Juha Murray, Graham K Koskela, Jari Mäki, Pirjo Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder. |
topic_facet |
Antenatal Bipolar disorder Depression Mood disorders Parental mental disorder Schizophrenia Adolescent Adult Adult Children Child Child of Impaired Parents Cohort Studies Depressive Disorder Female Finland Follow-Up Studies Humans Mother-Child Relations Mothers Pregnancy Pregnancy Complications Prenatal Diagnosis Schizophrenic Psychology Young Adult |
description |
BACKGROUND: Maternal antenatal depression may alter offspring neurodevelopment, but long follow-up studies are lacking. We studied the risks for mood disorders and schizophrenia in adult offspring of antenatally depressed mothers, taking account parental severe mental disorders. METHODS: In the general population-based Northern Finland 1966 Birth Cohort with 12,058 children, 13.9% of the mothers reported themselves depressed at mid-gestation. The offspring were followed 43 years. Severe mood disorders and schizophrenia in the offspring and severe mental disorders in the parents were detected using the Care Register for Healthcare. Maternal smoking during pregnancy, perinatal complications, fathers´ social class, family type at birth, and grand multiparity were considered as confounding variables. RESULTS: The offspring of antenatally depressed mothers had an elevated risk for depression (adjusted OR 1.5; 95% CI 1.03-2.2), compared to cohort members without maternal antenatal depressed mood. The offspring with maternal antenatal depressed mood and parental severe mental disorder had markedly elevated risks for depression (3.3; 1.8-6.2), and schizophrenia (3.9; 2.0-7.5), compared to the offspring without one or both of these risk factors. LIMITATIONS: Maternal antenatal depressed mood was determined by one question and did not necessarily signify a clinical condition. Data on maternal postnatal mood was not available. CONCLUSION: The offspring with maternal antenatal depressed mood and parental severe mental disorder had high risk for depression and schizophrenia. Early interventions in parental severe mental disorder might present an opportunity for decreasing the risk for mood disorders and schizophrenia in the offspring. |
format |
Article in Journal/Newspaper |
author |
Taka-Eilola Nèe Riekki, Tiina Veijola, Juha Murray, Graham K Koskela, Jari Mäki, Pirjo |
author_facet |
Taka-Eilola Nèe Riekki, Tiina Veijola, Juha Murray, Graham K Koskela, Jari Mäki, Pirjo |
author_sort |
Taka-Eilola Nèe Riekki, Tiina |
title |
Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder. |
title_short |
Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder. |
title_full |
Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder. |
title_fullStr |
Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder. |
title_full_unstemmed |
Severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the Northern Finland 1966 Birth Cohort: Relationship to parental severe mental disorder. |
title_sort |
severe mood disorders and schizophrenia in the adult offspring of antenatally depressed mothers in the northern finland 1966 birth cohort: relationship to parental severe mental disorder. |
publisher |
Elsevier BV |
publishDate |
2019 |
url |
https://www.repository.cam.ac.uk/handle/1810/289662 https://doi.org/10.17863/CAM.36910 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
https://www.repository.cam.ac.uk/handle/1810/289662 doi:10.17863/CAM.36910 |
op_doi |
https://doi.org/10.17863/CAM.36910 |
_version_ |
1789970497832747008 |