Antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study.
The aim of this paper was to investigate differences in brain structure volumes between schizophrenia and affective psychoses, and whether cumulative lifetime antipsychotic or benzodiazepine doses relate to brain morphology in these groups. We conducted two systematic reviews on the topic and invest...
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ftunivcam:oai:www.repository.cam.ac.uk:1810/285787 2024-02-04T10:03:14+01:00 Antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study. Huhtaniska, Sanna Korkala, Iikka Heikka, Tuomas Björnholm, Lassi Lehtiniemi, Heli Hulkko, Anja P Moilanen, Jani Tohka, Jussi Manjón, José Coupé, Pierrick Kiviniemi, Vesa Isohanni, Matti Koponen, Hannu Murray, Graham K Miettunen, Jouko Jääskeläinen, Erika 2018-11-30 Print-Electronic application/vnd.openxmlformats-officedocument.wordprocessingml.document https://www.repository.cam.ac.uk/handle/1810/285787 https://doi.org/10.17863/CAM.33131 eng eng Elsevier BV http://dx.doi.org/10.1016/j.pscychresns.2018.08.015 Psychiatry Res Neuroimaging https://www.repository.cam.ac.uk/handle/1810/285787 doi:10.17863/CAM.33131 Affective psychoses Brain MRI Psychopharmacology Schizophrenia Adult Affective Disorders Psychotic Antipsychotic Agents Benzodiazepines Cohort Studies Female Finland Humans Linear Models Magnetic Resonance Imaging Male Organ Size Article 2018 ftunivcam https://doi.org/10.17863/CAM.33131 2024-01-11T23:27:08Z The aim of this paper was to investigate differences in brain structure volumes between schizophrenia and affective psychoses, and whether cumulative lifetime antipsychotic or benzodiazepine doses relate to brain morphology in these groups. We conducted two systematic reviews on the topic and investigated 44 schizophrenia cases and 19 with affective psychoses from the Northern Finland Birth Cohort 1966. The association between lifetime antipsychotic and benzodiazepine dose and brain MRI scans at the age of 43 was investigated using linear regression. Intracranial volume, sex, illness severity, and antipsychotic/benzodiazepine doses were used as covariates. There were no differences between the groups in brain structure volumes. In schizophrenia, after adjusting for benzodiazepine dose and symptoms, a negative association between lifetime antipsychotic dose and the nucleus accumbens volume remained. In affective psychoses, higher lifetime benzodiazepine dose associated with larger volumes of total gray matter and hippocampal volume after controlling for antipsychotic use and symptoms. It seems that in addition to antipsychotics, the severity of symptoms and benzodiazepine dose are also associated with brain structure volumes. These results suggest, that benzodiazepine effects should also be investigated also independently and not only as a confounder. Article in Journal/Newspaper Northern Finland Apollo - University of Cambridge Repository |
institution |
Open Polar |
collection |
Apollo - University of Cambridge Repository |
op_collection_id |
ftunivcam |
language |
English |
topic |
Affective psychoses Brain MRI Psychopharmacology Schizophrenia Adult Affective Disorders Psychotic Antipsychotic Agents Benzodiazepines Cohort Studies Female Finland Humans Linear Models Magnetic Resonance Imaging Male Organ Size |
spellingShingle |
Affective psychoses Brain MRI Psychopharmacology Schizophrenia Adult Affective Disorders Psychotic Antipsychotic Agents Benzodiazepines Cohort Studies Female Finland Humans Linear Models Magnetic Resonance Imaging Male Organ Size Huhtaniska, Sanna Korkala, Iikka Heikka, Tuomas Björnholm, Lassi Lehtiniemi, Heli Hulkko, Anja P Moilanen, Jani Tohka, Jussi Manjón, José Coupé, Pierrick Kiviniemi, Vesa Isohanni, Matti Koponen, Hannu Murray, Graham K Miettunen, Jouko Jääskeläinen, Erika Antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study. |
topic_facet |
Affective psychoses Brain MRI Psychopharmacology Schizophrenia Adult Affective Disorders Psychotic Antipsychotic Agents Benzodiazepines Cohort Studies Female Finland Humans Linear Models Magnetic Resonance Imaging Male Organ Size |
description |
The aim of this paper was to investigate differences in brain structure volumes between schizophrenia and affective psychoses, and whether cumulative lifetime antipsychotic or benzodiazepine doses relate to brain morphology in these groups. We conducted two systematic reviews on the topic and investigated 44 schizophrenia cases and 19 with affective psychoses from the Northern Finland Birth Cohort 1966. The association between lifetime antipsychotic and benzodiazepine dose and brain MRI scans at the age of 43 was investigated using linear regression. Intracranial volume, sex, illness severity, and antipsychotic/benzodiazepine doses were used as covariates. There were no differences between the groups in brain structure volumes. In schizophrenia, after adjusting for benzodiazepine dose and symptoms, a negative association between lifetime antipsychotic dose and the nucleus accumbens volume remained. In affective psychoses, higher lifetime benzodiazepine dose associated with larger volumes of total gray matter and hippocampal volume after controlling for antipsychotic use and symptoms. It seems that in addition to antipsychotics, the severity of symptoms and benzodiazepine dose are also associated with brain structure volumes. These results suggest, that benzodiazepine effects should also be investigated also independently and not only as a confounder. |
format |
Article in Journal/Newspaper |
author |
Huhtaniska, Sanna Korkala, Iikka Heikka, Tuomas Björnholm, Lassi Lehtiniemi, Heli Hulkko, Anja P Moilanen, Jani Tohka, Jussi Manjón, José Coupé, Pierrick Kiviniemi, Vesa Isohanni, Matti Koponen, Hannu Murray, Graham K Miettunen, Jouko Jääskeläinen, Erika |
author_facet |
Huhtaniska, Sanna Korkala, Iikka Heikka, Tuomas Björnholm, Lassi Lehtiniemi, Heli Hulkko, Anja P Moilanen, Jani Tohka, Jussi Manjón, José Coupé, Pierrick Kiviniemi, Vesa Isohanni, Matti Koponen, Hannu Murray, Graham K Miettunen, Jouko Jääskeläinen, Erika |
author_sort |
Huhtaniska, Sanna |
title |
Antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study. |
title_short |
Antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study. |
title_full |
Antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study. |
title_fullStr |
Antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study. |
title_full_unstemmed |
Antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study. |
title_sort |
antipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - systematic reviews and birth cohort study. |
publisher |
Elsevier BV |
publishDate |
2018 |
url |
https://www.repository.cam.ac.uk/handle/1810/285787 https://doi.org/10.17863/CAM.33131 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
https://www.repository.cam.ac.uk/handle/1810/285787 doi:10.17863/CAM.33131 |
op_doi |
https://doi.org/10.17863/CAM.33131 |
_version_ |
1789970506212966400 |