Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function.
BACKGROUND: Progressive brain volume loss in schizophrenia has been reported in previous studies but its cause and regional distribution remains unclear. We investigated progressive regional brain reductions in schizophrenia and correlations with potential mediators. METHOD: Participants were drawn...
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ftunivcam:oai:www.repository.cam.ac.uk:1810/248937 2024-04-28T08:32:26+00:00 Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function. Guo, Joyce Y Huhtaniska, Sanna Miettunen, Jouko Jääskeläinen, Erika Kiviniemi, Vesa Nikkinen, Juha Moilanen, Jani Haapea, Marianne Mäki, Pirjo Jones, Peter B Veijola, Juha Isohanni, Matti Murray, Graham K 2015-10 application/pdf https://www.repository.cam.ac.uk/handle/1810/248937 English eng eng Elsevier BV http://dx.doi.org/10.1016/j.schres.2015.06.016 Schizophr Res https://www.repository.cam.ac.uk/handle/1810/248937 Creative Commons Attribution 4.0 http://creativecommons.org/licenses/by/4.0/ Antipsychotic medication Longitudinal MRI Schizophrenia Adult Antipsychotic Agents Brain Cohort Studies Female Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Psychiatric Status Rating Scales Schizophrenic Psychology Statistics Nonparametric Article 2015 ftunivcam 2024-04-03T14:15:09Z BACKGROUND: Progressive brain volume loss in schizophrenia has been reported in previous studies but its cause and regional distribution remains unclear. We investigated progressive regional brain reductions in schizophrenia and correlations with potential mediators. METHOD: Participants were drawn from the Northern Finland Birth Cohort 1966. A total of 33 schizophrenia individuals and 71 controls were MRI scanned at baseline (mean age=34.7, SD=0.77) and at follow-up (mean age=43.4, SD=0.44). Regional brain change differences and associations with clinical mediators were examined using FSL voxelwise SIENA. RESULTS: Schizophrenia cases exhibited greater progressive brain reductions than controls, mainly in the frontal and temporal lobes. The degree of periventricular brain volume reductions were predicted by antipsychotic medication exposure at the fourth ventricular edge and by the number of days in hospital between the scans (a proxy measure of relapse duration) at the thalamic ventricular border. Decline in social and occupational functioning was associated with right supramarginal gyrus reduction. CONCLUSION: Our findings are consistent with the possibility that antipsychotic medication exposure and time spent in relapse partially explain progressive brain reductions in schizophrenia. However, residual confounding could also account for the findings and caution must be applied before drawing causal inferences from associations demonstrated in observational studies of modest size. Less progressive brain volume loss in schizophrenia may indicate better preserved social and occupational functions. Academy of Finland, Medical Research Council, Sigrid Jusélius Foundation and the Signe and Ane Gyllenberg Foundation, Finland, Stanley Foundation, Brain & Behavior Research Foundation. The work was partially completed within the University of Cambridge Behavioural and Clinical Neuroscience Institute, supported by a joint award from the Medical Research Council and Wellcome Trust. This is the final version of ... Article in Journal/Newspaper Northern Finland Apollo - University of Cambridge Repository |
institution |
Open Polar |
collection |
Apollo - University of Cambridge Repository |
op_collection_id |
ftunivcam |
language |
English |
topic |
Antipsychotic medication Longitudinal MRI Schizophrenia Adult Antipsychotic Agents Brain Cohort Studies Female Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Psychiatric Status Rating Scales Schizophrenic Psychology Statistics Nonparametric |
spellingShingle |
Antipsychotic medication Longitudinal MRI Schizophrenia Adult Antipsychotic Agents Brain Cohort Studies Female Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Psychiatric Status Rating Scales Schizophrenic Psychology Statistics Nonparametric Guo, Joyce Y Huhtaniska, Sanna Miettunen, Jouko Jääskeläinen, Erika Kiviniemi, Vesa Nikkinen, Juha Moilanen, Jani Haapea, Marianne Mäki, Pirjo Jones, Peter B Veijola, Juha Isohanni, Matti Murray, Graham K Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function. |
topic_facet |
Antipsychotic medication Longitudinal MRI Schizophrenia Adult Antipsychotic Agents Brain Cohort Studies Female Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Psychiatric Status Rating Scales Schizophrenic Psychology Statistics Nonparametric |
description |
BACKGROUND: Progressive brain volume loss in schizophrenia has been reported in previous studies but its cause and regional distribution remains unclear. We investigated progressive regional brain reductions in schizophrenia and correlations with potential mediators. METHOD: Participants were drawn from the Northern Finland Birth Cohort 1966. A total of 33 schizophrenia individuals and 71 controls were MRI scanned at baseline (mean age=34.7, SD=0.77) and at follow-up (mean age=43.4, SD=0.44). Regional brain change differences and associations with clinical mediators were examined using FSL voxelwise SIENA. RESULTS: Schizophrenia cases exhibited greater progressive brain reductions than controls, mainly in the frontal and temporal lobes. The degree of periventricular brain volume reductions were predicted by antipsychotic medication exposure at the fourth ventricular edge and by the number of days in hospital between the scans (a proxy measure of relapse duration) at the thalamic ventricular border. Decline in social and occupational functioning was associated with right supramarginal gyrus reduction. CONCLUSION: Our findings are consistent with the possibility that antipsychotic medication exposure and time spent in relapse partially explain progressive brain reductions in schizophrenia. However, residual confounding could also account for the findings and caution must be applied before drawing causal inferences from associations demonstrated in observational studies of modest size. Less progressive brain volume loss in schizophrenia may indicate better preserved social and occupational functions. Academy of Finland, Medical Research Council, Sigrid Jusélius Foundation and the Signe and Ane Gyllenberg Foundation, Finland, Stanley Foundation, Brain & Behavior Research Foundation. The work was partially completed within the University of Cambridge Behavioural and Clinical Neuroscience Institute, supported by a joint award from the Medical Research Council and Wellcome Trust. This is the final version of ... |
format |
Article in Journal/Newspaper |
author |
Guo, Joyce Y Huhtaniska, Sanna Miettunen, Jouko Jääskeläinen, Erika Kiviniemi, Vesa Nikkinen, Juha Moilanen, Jani Haapea, Marianne Mäki, Pirjo Jones, Peter B Veijola, Juha Isohanni, Matti Murray, Graham K |
author_facet |
Guo, Joyce Y Huhtaniska, Sanna Miettunen, Jouko Jääskeläinen, Erika Kiviniemi, Vesa Nikkinen, Juha Moilanen, Jani Haapea, Marianne Mäki, Pirjo Jones, Peter B Veijola, Juha Isohanni, Matti Murray, Graham K |
author_sort |
Guo, Joyce Y |
title |
Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function. |
title_short |
Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function. |
title_full |
Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function. |
title_fullStr |
Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function. |
title_full_unstemmed |
Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function. |
title_sort |
longitudinal regional brain volume loss in schizophrenia: relationship to antipsychotic medication and change in social function. |
publisher |
Elsevier BV |
publishDate |
2015 |
url |
https://www.repository.cam.ac.uk/handle/1810/248937 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
https://www.repository.cam.ac.uk/handle/1810/248937 |
op_rights |
Creative Commons Attribution 4.0 http://creativecommons.org/licenses/by/4.0/ |
_version_ |
1797589634005336064 |