A Case Study: Was Private William Braine of the 1845 Franklin Expedition a Victim of Tuberculosis? + Supplementary Appendix 1 (See Article Tools)

The Franklin expedition set sail in 1845 in search of the Northwest Passage through the Canadian Arctic. During the first winter in the Arctic, three crewmen died of unknown causes. In the 1980s, Dr. Owen Beattie and his colleagues conducted autopsies, which indicated that all three may have suffere...

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Published in:ARCTIC
Main Authors: Forst, Jannine, Brown, Terence A.
Format: Article in Journal/Newspaper
Language:English
Published: The Arctic Institute of North America 2017
Subjects:
Online Access:https://journalhosting.ucalgary.ca/index.php/arctic/article/view/67721
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author Forst, Jannine
Brown, Terence A.
author_facet Forst, Jannine
Brown, Terence A.
author_sort Forst, Jannine
collection Unknown
container_issue 4
container_title ARCTIC
container_volume 70
description The Franklin expedition set sail in 1845 in search of the Northwest Passage through the Canadian Arctic. During the first winter in the Arctic, three crewmen died of unknown causes. In the 1980s, Dr. Owen Beattie and his colleagues conducted autopsies, which indicated that all three may have suffered from tuberculosis at the time of death. In the present study, a bone sample from one of these individuals, Private William Braine, was analyzed for ancient DNA belonging to Mycobacterium tuberculosis. Tests based on both the polymerase chain reaction and next-generation sequencing were carried out. The results show that it is unlikely that tuberculosis contributed directly to his death. L’expédition de Franklin a dressé les voiles en 1845, à la recherche du passage du Nord-Ouest, dans l’Arctique canadien. Pendant leur premier hiver dans l’Arctique, trois membres de l’équipe sont morts de causes inconnues. Dans les années 1980, le Dr Owen Beattie et ses collègues ont réalisé des autopsies, et celles-ci ont permis de constater que les trois hommes en question souffraient peut-être de tuberculose au moment de leur mort. Dans la présente étude, un échantillon d’os de l’un de ces hommes, soit le soldat William Braine, a été analysé afin d’en prélever l’ADN ancien appartenant au Mycobacterium tuberculosis. Des tests basés sur la réaction en chaîne de la polymérase et le séquençage de nouvelle génération ont été effectués. Selon les résultats, il est peu probable que la tuberculose ait entraîné directement la mort de ce soldat.
format Article in Journal/Newspaper
genre Arctic
Arctic
Northwest passage
Passage du Nord-Ouest
genre_facet Arctic
Arctic
Northwest passage
Passage du Nord-Ouest
geographic Arctic
Northwest Passage
Soldat
geographic_facet Arctic
Northwest Passage
Soldat
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language English
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op_rights Copyright (c) 2017 ARCTIC
op_source ARCTIC; Vol. 70 No. 4 (2017): December: 343–445; 381–388
1923-1245
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publisher The Arctic Institute of North America
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spelling ftunivcalgaryojs:oai:journalhosting.ucalgary.ca:article/67721 2025-06-15T14:14:02+00:00 A Case Study: Was Private William Braine of the 1845 Franklin Expedition a Victim of Tuberculosis? + Supplementary Appendix 1 (See Article Tools) Forst, Jannine Brown, Terence A. 2017-12-03 application/pdf https://journalhosting.ucalgary.ca/index.php/arctic/article/view/67721 eng eng The Arctic Institute of North America https://journalhosting.ucalgary.ca/index.php/arctic/article/view/67721/51617 https://journalhosting.ucalgary.ca/index.php/arctic/article/view/67721/53115 https://journalhosting.ucalgary.ca/index.php/arctic/article/view/67721 Copyright (c) 2017 ARCTIC ARCTIC; Vol. 70 No. 4 (2017): December: 343–445; 381–388 1923-1245 0004-0843 archaeology DNA Franklin expedition Northwest Passage paleogenetics tuberculosis William Braine archéologie ADN expédition de Franklin passage du Nord-Ouest paléogénétique tuberculose info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion research-article 2017 ftunivcalgaryojs 2025-05-27T03:29:43Z The Franklin expedition set sail in 1845 in search of the Northwest Passage through the Canadian Arctic. During the first winter in the Arctic, three crewmen died of unknown causes. In the 1980s, Dr. Owen Beattie and his colleagues conducted autopsies, which indicated that all three may have suffered from tuberculosis at the time of death. In the present study, a bone sample from one of these individuals, Private William Braine, was analyzed for ancient DNA belonging to Mycobacterium tuberculosis. Tests based on both the polymerase chain reaction and next-generation sequencing were carried out. The results show that it is unlikely that tuberculosis contributed directly to his death. L’expédition de Franklin a dressé les voiles en 1845, à la recherche du passage du Nord-Ouest, dans l’Arctique canadien. Pendant leur premier hiver dans l’Arctique, trois membres de l’équipe sont morts de causes inconnues. Dans les années 1980, le Dr Owen Beattie et ses collègues ont réalisé des autopsies, et celles-ci ont permis de constater que les trois hommes en question souffraient peut-être de tuberculose au moment de leur mort. Dans la présente étude, un échantillon d’os de l’un de ces hommes, soit le soldat William Braine, a été analysé afin d’en prélever l’ADN ancien appartenant au Mycobacterium tuberculosis. Des tests basés sur la réaction en chaîne de la polymérase et le séquençage de nouvelle génération ont été effectués. Selon les résultats, il est peu probable que la tuberculose ait entraîné directement la mort de ce soldat. Article in Journal/Newspaper Arctic Arctic Northwest passage Passage du Nord-Ouest Unknown Arctic Northwest Passage Soldat ENVELOPE(153.979,153.979,69.397,69.397) ARCTIC 70 4
spellingShingle archaeology
DNA
Franklin expedition
Northwest Passage
paleogenetics
tuberculosis
William Braine
archéologie
ADN
expédition de Franklin
passage du Nord-Ouest
paléogénétique
tuberculose
Forst, Jannine
Brown, Terence A.
A Case Study: Was Private William Braine of the 1845 Franklin Expedition a Victim of Tuberculosis? + Supplementary Appendix 1 (See Article Tools)
title A Case Study: Was Private William Braine of the 1845 Franklin Expedition a Victim of Tuberculosis? + Supplementary Appendix 1 (See Article Tools)
title_full A Case Study: Was Private William Braine of the 1845 Franklin Expedition a Victim of Tuberculosis? + Supplementary Appendix 1 (See Article Tools)
title_fullStr A Case Study: Was Private William Braine of the 1845 Franklin Expedition a Victim of Tuberculosis? + Supplementary Appendix 1 (See Article Tools)
title_full_unstemmed A Case Study: Was Private William Braine of the 1845 Franklin Expedition a Victim of Tuberculosis? + Supplementary Appendix 1 (See Article Tools)
title_short A Case Study: Was Private William Braine of the 1845 Franklin Expedition a Victim of Tuberculosis? + Supplementary Appendix 1 (See Article Tools)
title_sort case study: was private william braine of the 1845 franklin expedition a victim of tuberculosis? + supplementary appendix 1 (see article tools)
topic archaeology
DNA
Franklin expedition
Northwest Passage
paleogenetics
tuberculosis
William Braine
archéologie
ADN
expédition de Franklin
passage du Nord-Ouest
paléogénétique
tuberculose
topic_facet archaeology
DNA
Franklin expedition
Northwest Passage
paleogenetics
tuberculosis
William Braine
archéologie
ADN
expédition de Franklin
passage du Nord-Ouest
paléogénétique
tuberculose
url https://journalhosting.ucalgary.ca/index.php/arctic/article/view/67721