The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus)
Vitamin D is a steroid that promotes healthy bone structure and muscle function. It is obtained from the diet and synthesized in the skin during UV-B exposure from sunlight. In muscle, it influences calcium transport and promotes growth, with varied responses depending on muscle type. I hypothesized...
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ftunivcalgary:oai:prism.ucalgary.ca:1880/111017 2023-08-27T04:08:08+02:00 The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) Tsao, Natalie Syme, Douglas A. Barclay, Robert M. R. Burton, Jodie M. 2019-09-17 application/pdf http://hdl.handle.net/1880/111017 https://doi.org/10.11575/PRISM/37082 eng eng Science University of Calgary Tsao, N. (2019). The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) (Unpublished master's thesis). University of Calgary, Calgary, AB. http://dx.doi.org/10.11575/PRISM/37082 http://hdl.handle.net/1880/111017 University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Mice Vitamin D Muscle Performance Fast-twitch Muscles Slow-twitch Muscles Ultraviolet B Education--Health Animal Pathology Food Science and Technology Animal Physiology Physiology Veterinary Science Zoology master thesis 2019 ftunivcalgary https://doi.org/10.11575/PRISM/37082 2023-08-06T06:30:02Z Vitamin D is a steroid that promotes healthy bone structure and muscle function. It is obtained from the diet and synthesized in the skin during UV-B exposure from sunlight. In muscle, it influences calcium transport and promotes growth, with varied responses depending on muscle type. I hypothesized that reduced vitamin D in the diet and removal of UVB light, as occurs during hibernation or the Polar winter, will impact circulating levels of vitamin D to the extent that muscle contractile performance is altered. I also hypothesize that fast-twitch muscles will show greater responses of muscle contractile capabilities to treatments compared to slow-twitch muscles. Mice were used as a model, and fed diets with normal or low vitamin D, and exposed to normal or no UV-B doses for 3 months. Neither fast nor slow muscle types showed significant differences between treatment groups in force, power, force-velocity measures, or rates of fatigue. Serum vitamin D levels, measured at the midpoint and endpoint of the treatment, varied substantially among individuals, but not, on average, among treatment groups, indicating mechanisms of compensatory homeostasis in the face of reduced vitamin D supply. These results suggest that intermittent interruptions in dietary vitamin D or light exposure in mammals, such as those that hibernate or live above the Arctic Circle, do not impair muscle contractile function. Master Thesis Arctic PRISM - University of Calgary Digital Repository Arctic |
institution |
Open Polar |
collection |
PRISM - University of Calgary Digital Repository |
op_collection_id |
ftunivcalgary |
language |
English |
topic |
Mice Vitamin D Muscle Performance Fast-twitch Muscles Slow-twitch Muscles Ultraviolet B Education--Health Animal Pathology Food Science and Technology Animal Physiology Physiology Veterinary Science Zoology |
spellingShingle |
Mice Vitamin D Muscle Performance Fast-twitch Muscles Slow-twitch Muscles Ultraviolet B Education--Health Animal Pathology Food Science and Technology Animal Physiology Physiology Veterinary Science Zoology Tsao, Natalie The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) |
topic_facet |
Mice Vitamin D Muscle Performance Fast-twitch Muscles Slow-twitch Muscles Ultraviolet B Education--Health Animal Pathology Food Science and Technology Animal Physiology Physiology Veterinary Science Zoology |
description |
Vitamin D is a steroid that promotes healthy bone structure and muscle function. It is obtained from the diet and synthesized in the skin during UV-B exposure from sunlight. In muscle, it influences calcium transport and promotes growth, with varied responses depending on muscle type. I hypothesized that reduced vitamin D in the diet and removal of UVB light, as occurs during hibernation or the Polar winter, will impact circulating levels of vitamin D to the extent that muscle contractile performance is altered. I also hypothesize that fast-twitch muscles will show greater responses of muscle contractile capabilities to treatments compared to slow-twitch muscles. Mice were used as a model, and fed diets with normal or low vitamin D, and exposed to normal or no UV-B doses for 3 months. Neither fast nor slow muscle types showed significant differences between treatment groups in force, power, force-velocity measures, or rates of fatigue. Serum vitamin D levels, measured at the midpoint and endpoint of the treatment, varied substantially among individuals, but not, on average, among treatment groups, indicating mechanisms of compensatory homeostasis in the face of reduced vitamin D supply. These results suggest that intermittent interruptions in dietary vitamin D or light exposure in mammals, such as those that hibernate or live above the Arctic Circle, do not impair muscle contractile function. |
author2 |
Syme, Douglas A. Barclay, Robert M. R. Burton, Jodie M. |
format |
Master Thesis |
author |
Tsao, Natalie |
author_facet |
Tsao, Natalie |
author_sort |
Tsao, Natalie |
title |
The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) |
title_short |
The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) |
title_full |
The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) |
title_fullStr |
The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) |
title_full_unstemmed |
The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) |
title_sort |
effects of diet and ultra violet b exposure on vitamin d levels and muscle performance in mice (mus musculus) |
publisher |
Science |
publishDate |
2019 |
url |
http://hdl.handle.net/1880/111017 https://doi.org/10.11575/PRISM/37082 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
Tsao, N. (2019). The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) (Unpublished master's thesis). University of Calgary, Calgary, AB. http://dx.doi.org/10.11575/PRISM/37082 http://hdl.handle.net/1880/111017 |
op_rights |
University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. |
op_doi |
https://doi.org/10.11575/PRISM/37082 |
_version_ |
1775348834775334912 |