Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities
Abstract Background Indigenous communities across the circumpolar north have elevated H. pylori (Hp) prevalence and stomach cancer incidence. We aimed to describe the Hp-associated disease burden among western Canadian Arctic participants in community-driven projects that address concerns about heal...
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ftunivcalgary:oai:prism.ucalgary.ca:1880/110499 2024-09-09T19:21:23+00:00 Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities Fagan-Garcia, Katharine Geary, Janis Chang, Hsiu-Ju McAlpine, Laura Walker, Emily Colquhoun, Amy van Zanten, Sander V Girgis, Safwat Archie, Billy Hanley, Brendan Corriveau, Andre Morse, John Munday, Rachel Goodman, Karen J 2019-06-16T00:07:30Z application/pdf http://hdl.handle.net/1880/110499 https://doi.org/10.11575/PRISM/44590 https://doi.org/10.1186/s12889-019-7065-x en eng BMC Public Health. 2019 Jun 11;19(1):730 http://hdl.handle.net/1880/110499 https://doi.org/10.11575/PRISM/44590 https://doi.org/10.1186/s12889-019-7065-x The Author(s). Journal Article 2019 ftunivcalgary https://doi.org/10.11575/PRISM/4459010.1186/s12889-019-7065-x 2024-07-30T23:46:17Z Abstract Background Indigenous communities across the circumpolar north have elevated H. pylori (Hp) prevalence and stomach cancer incidence. We aimed to describe the Hp-associated disease burden among western Canadian Arctic participants in community-driven projects that address concerns about health risks from Hp infection. Methods During 2008–2013, participants underwent Hp screening by urea breath test and gastroscopy with gastric biopsies. We estimated Hp prevalence and prevalence by Hp status of endoscopic and histopathologic diagnoses. Results Among 878 participants with Hp status data, Hp prevalence was: 62% overall; 66% in 740 Indigenous participants; 22% in 77 non-Indigenous participants (61 participants did not disclose ethnicity); 45% at 0–14 years old, 69% at 15–34 years old, and 61% at 35–96 years old. Among 309 participants examined endoscopically, visible mucosal lesions were more frequent in the stomach than the duodenum: the gastric to duodenal ratio was 2 for inflammation, 8 for erosions, and 3 for ulcers. Pathological examination in 308 participants with gastric biopsies revealed normal gastric mucosa in 1 of 224 Hp-positive participants and 77% (65/84) of Hp-negative participants with sharp contrasts in the prevalence of abnormalities between Hp-positive and Hp-negative participants, respectively: moderate-severe active gastritis in 50 and 0%; moderate-severe chronic gastritis in 91 and 1%; atrophic gastritis in 43 and 0%; intestinal metaplasia in 17 and 5%. Conclusions The observed pattern of disease is consistent with increased risk of stomach cancer and reflects substantial inequity in the Hp-associated disease burden in western Arctic Canadian hamlets relative to most North American settings. This research adds to evidence that demonstrates the need for interventions aimed at reducing health risks from Hp infection in Indigenous Arctic communities. Article in Journal/Newspaper Arctic PRISM - University of Calgary Digital Repository Arctic BMC Public Health 19 1 |
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Open Polar |
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PRISM - University of Calgary Digital Repository |
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ftunivcalgary |
language |
English |
description |
Abstract Background Indigenous communities across the circumpolar north have elevated H. pylori (Hp) prevalence and stomach cancer incidence. We aimed to describe the Hp-associated disease burden among western Canadian Arctic participants in community-driven projects that address concerns about health risks from Hp infection. Methods During 2008–2013, participants underwent Hp screening by urea breath test and gastroscopy with gastric biopsies. We estimated Hp prevalence and prevalence by Hp status of endoscopic and histopathologic diagnoses. Results Among 878 participants with Hp status data, Hp prevalence was: 62% overall; 66% in 740 Indigenous participants; 22% in 77 non-Indigenous participants (61 participants did not disclose ethnicity); 45% at 0–14 years old, 69% at 15–34 years old, and 61% at 35–96 years old. Among 309 participants examined endoscopically, visible mucosal lesions were more frequent in the stomach than the duodenum: the gastric to duodenal ratio was 2 for inflammation, 8 for erosions, and 3 for ulcers. Pathological examination in 308 participants with gastric biopsies revealed normal gastric mucosa in 1 of 224 Hp-positive participants and 77% (65/84) of Hp-negative participants with sharp contrasts in the prevalence of abnormalities between Hp-positive and Hp-negative participants, respectively: moderate-severe active gastritis in 50 and 0%; moderate-severe chronic gastritis in 91 and 1%; atrophic gastritis in 43 and 0%; intestinal metaplasia in 17 and 5%. Conclusions The observed pattern of disease is consistent with increased risk of stomach cancer and reflects substantial inequity in the Hp-associated disease burden in western Arctic Canadian hamlets relative to most North American settings. This research adds to evidence that demonstrates the need for interventions aimed at reducing health risks from Hp infection in Indigenous Arctic communities. |
format |
Article in Journal/Newspaper |
author |
Fagan-Garcia, Katharine Geary, Janis Chang, Hsiu-Ju McAlpine, Laura Walker, Emily Colquhoun, Amy van Zanten, Sander V Girgis, Safwat Archie, Billy Hanley, Brendan Corriveau, Andre Morse, John Munday, Rachel Goodman, Karen J |
spellingShingle |
Fagan-Garcia, Katharine Geary, Janis Chang, Hsiu-Ju McAlpine, Laura Walker, Emily Colquhoun, Amy van Zanten, Sander V Girgis, Safwat Archie, Billy Hanley, Brendan Corriveau, Andre Morse, John Munday, Rachel Goodman, Karen J Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities |
author_facet |
Fagan-Garcia, Katharine Geary, Janis Chang, Hsiu-Ju McAlpine, Laura Walker, Emily Colquhoun, Amy van Zanten, Sander V Girgis, Safwat Archie, Billy Hanley, Brendan Corriveau, Andre Morse, John Munday, Rachel Goodman, Karen J |
author_sort |
Fagan-Garcia, Katharine |
title |
Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities |
title_short |
Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities |
title_full |
Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities |
title_fullStr |
Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities |
title_full_unstemmed |
Burden of disease from Helicobacter pylori infection in western Canadian Arctic communities |
title_sort |
burden of disease from helicobacter pylori infection in western canadian arctic communities |
publishDate |
2019 |
url |
http://hdl.handle.net/1880/110499 https://doi.org/10.11575/PRISM/44590 https://doi.org/10.1186/s12889-019-7065-x |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
BMC Public Health. 2019 Jun 11;19(1):730 http://hdl.handle.net/1880/110499 https://doi.org/10.11575/PRISM/44590 https://doi.org/10.1186/s12889-019-7065-x |
op_rights |
The Author(s). |
op_doi |
https://doi.org/10.11575/PRISM/4459010.1186/s12889-019-7065-x |
container_title |
BMC Public Health |
container_volume |
19 |
container_issue |
1 |
_version_ |
1809761583488827392 |