Mitochondrial function and reactive oxygen species : effects of gender and endurance training in Wistar rat and European eel
Mitochondrion is the main site of aerobic energy (ATP) and reactive oxygen species (ROS) productions. Mitochondrial function is closely linked to ROS, which, according their rate, can alter or optimize energy efficiency. Structural and functional plasticity of mitochondria is essential to maintain h...
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Online Access: | https://tel.archives-ouvertes.fr/tel-02012420 https://tel.archives-ouvertes.fr/tel-02012420/document https://tel.archives-ouvertes.fr/tel-02012420/file/These-2015-SICMA-Aspects_moleculaires_et_cellulaires_de_la_biologie-FARHAT_Firas.pdf |
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ftunivbrest:oai:HAL:tel-02012420v1 2023-05-15T13:28:29+02:00 Mitochondrial function and reactive oxygen species : effects of gender and endurance training in Wistar rat and European eel Fonction mitochondriale et espèces réactives dérivées de l'oxygène : effets du genre et de l'entraînement en endurance chez le rat Wistar et l'anguille européenne Farhat, Firas Optimisation des régulations physiologiques (ORPHY (EA 4324)) Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM) Université de Brest (UBO)-Université de Brest (UBO) Université de Bretagne occidentale - Brest Christine Moisan 2015-03-20 https://tel.archives-ouvertes.fr/tel-02012420 https://tel.archives-ouvertes.fr/tel-02012420/document https://tel.archives-ouvertes.fr/tel-02012420/file/These-2015-SICMA-Aspects_moleculaires_et_cellulaires_de_la_biologie-FARHAT_Firas.pdf fr fre HAL CCSD NNT: 2015BRES0018 tel-02012420 https://tel.archives-ouvertes.fr/tel-02012420 https://tel.archives-ouvertes.fr/tel-02012420/document https://tel.archives-ouvertes.fr/tel-02012420/file/These-2015-SICMA-Aspects_moleculaires_et_cellulaires_de_la_biologie-FARHAT_Firas.pdf info:eu-repo/semantics/OpenAccess https://tel.archives-ouvertes.fr/tel-02012420 Biologie cellulaire. Université de Bretagne occidentale - Brest, 2015. Français. ⟨NNT : 2015BRES0018⟩ Wistar rats European eel Gender Fish model Endurance training Mitochondrial function ROS Rat Wistar Anguille européenne Genre Modèle poisson Entrainement de type endurance Fonction mitochondriale [SDV.BC]Life Sciences [q-bio]/Cellular Biology info:eu-repo/semantics/doctoralThesis Theses 2015 ftunivbrest 2022-05-12T20:24:05Z Mitochondrion is the main site of aerobic energy (ATP) and reactive oxygen species (ROS) productions. Mitochondrial function is closely linked to ROS, which, according their rate, can alter or optimize energy efficiency. Structural and functional plasticity of mitochondria is essential to maintain homeostasis in any situation that requires metabolic adjustments as physical exercise. The adaptive mechanisms of mitochondrial function and ROS during training and the impact of gender on these responses are still far from being solved. In this perspective, two animal models (Wistar rat and European eel) were chosen.The effects of endurance training of the same intensity (70% of maximal aerobic speed running or swimming) were studied in Wistar rat and silver European eel. The latter is an enduring species capable of performing a spawning migration of 6000 km and characterized by sexual dimorphism in size. In vitro measurements of oxygen consumption, free radical and ATP productions were carried out simultaneously from heart and skeletal muscle permeabilized fibers. The vulnerability or resistance of the mitochondrial function to a ROS generating system exposure (mimicking oxidative stress) was also studied.Before training, in rat, female has a mitochondrial function energetically more efficient and more resistant to ROS, whereas in eel, this metabolic and radical profile is observed rather in male. After training, whatever the species, the improved physical performance observed is associated with various metabolic and radical changes which depending on gender and species. In rats, the improving of mitochondrial function translates differently according to gender. In male, training induces improvement in energy efficiency through a better coupling between oxidation and phosphorylation and/or better use of electrons at the respiratory chain level. In female, increasing in ATP production may be related to the increase in mitochondrial oxygen consumption. As in rats, training induces globally in eel an improvement in ... Doctoral or Postdoctoral Thesis Anguille européenne European eel Université de Bretagne Occidentale: HAL |
institution |
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Université de Bretagne Occidentale: HAL |
op_collection_id |
ftunivbrest |
language |
French |
topic |
Wistar rats European eel Gender Fish model Endurance training Mitochondrial function ROS Rat Wistar Anguille européenne Genre Modèle poisson Entrainement de type endurance Fonction mitochondriale [SDV.BC]Life Sciences [q-bio]/Cellular Biology |
spellingShingle |
Wistar rats European eel Gender Fish model Endurance training Mitochondrial function ROS Rat Wistar Anguille européenne Genre Modèle poisson Entrainement de type endurance Fonction mitochondriale [SDV.BC]Life Sciences [q-bio]/Cellular Biology Farhat, Firas Mitochondrial function and reactive oxygen species : effects of gender and endurance training in Wistar rat and European eel |
topic_facet |
Wistar rats European eel Gender Fish model Endurance training Mitochondrial function ROS Rat Wistar Anguille européenne Genre Modèle poisson Entrainement de type endurance Fonction mitochondriale [SDV.BC]Life Sciences [q-bio]/Cellular Biology |
description |
Mitochondrion is the main site of aerobic energy (ATP) and reactive oxygen species (ROS) productions. Mitochondrial function is closely linked to ROS, which, according their rate, can alter or optimize energy efficiency. Structural and functional plasticity of mitochondria is essential to maintain homeostasis in any situation that requires metabolic adjustments as physical exercise. The adaptive mechanisms of mitochondrial function and ROS during training and the impact of gender on these responses are still far from being solved. In this perspective, two animal models (Wistar rat and European eel) were chosen.The effects of endurance training of the same intensity (70% of maximal aerobic speed running or swimming) were studied in Wistar rat and silver European eel. The latter is an enduring species capable of performing a spawning migration of 6000 km and characterized by sexual dimorphism in size. In vitro measurements of oxygen consumption, free radical and ATP productions were carried out simultaneously from heart and skeletal muscle permeabilized fibers. The vulnerability or resistance of the mitochondrial function to a ROS generating system exposure (mimicking oxidative stress) was also studied.Before training, in rat, female has a mitochondrial function energetically more efficient and more resistant to ROS, whereas in eel, this metabolic and radical profile is observed rather in male. After training, whatever the species, the improved physical performance observed is associated with various metabolic and radical changes which depending on gender and species. In rats, the improving of mitochondrial function translates differently according to gender. In male, training induces improvement in energy efficiency through a better coupling between oxidation and phosphorylation and/or better use of electrons at the respiratory chain level. In female, increasing in ATP production may be related to the increase in mitochondrial oxygen consumption. As in rats, training induces globally in eel an improvement in ... |
author2 |
Optimisation des régulations physiologiques (ORPHY (EA 4324)) Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM) Université de Brest (UBO)-Université de Brest (UBO) Université de Bretagne occidentale - Brest Christine Moisan |
format |
Doctoral or Postdoctoral Thesis |
author |
Farhat, Firas |
author_facet |
Farhat, Firas |
author_sort |
Farhat, Firas |
title |
Mitochondrial function and reactive oxygen species : effects of gender and endurance training in Wistar rat and European eel |
title_short |
Mitochondrial function and reactive oxygen species : effects of gender and endurance training in Wistar rat and European eel |
title_full |
Mitochondrial function and reactive oxygen species : effects of gender and endurance training in Wistar rat and European eel |
title_fullStr |
Mitochondrial function and reactive oxygen species : effects of gender and endurance training in Wistar rat and European eel |
title_full_unstemmed |
Mitochondrial function and reactive oxygen species : effects of gender and endurance training in Wistar rat and European eel |
title_sort |
mitochondrial function and reactive oxygen species : effects of gender and endurance training in wistar rat and european eel |
publisher |
HAL CCSD |
publishDate |
2015 |
url |
https://tel.archives-ouvertes.fr/tel-02012420 https://tel.archives-ouvertes.fr/tel-02012420/document https://tel.archives-ouvertes.fr/tel-02012420/file/These-2015-SICMA-Aspects_moleculaires_et_cellulaires_de_la_biologie-FARHAT_Firas.pdf |
genre |
Anguille européenne European eel |
genre_facet |
Anguille européenne European eel |
op_source |
https://tel.archives-ouvertes.fr/tel-02012420 Biologie cellulaire. Université de Bretagne occidentale - Brest, 2015. Français. ⟨NNT : 2015BRES0018⟩ |
op_relation |
NNT: 2015BRES0018 tel-02012420 https://tel.archives-ouvertes.fr/tel-02012420 https://tel.archives-ouvertes.fr/tel-02012420/document https://tel.archives-ouvertes.fr/tel-02012420/file/These-2015-SICMA-Aspects_moleculaires_et_cellulaires_de_la_biologie-FARHAT_Firas.pdf |
op_rights |
info:eu-repo/semantics/OpenAccess |
_version_ |
1766404379955429376 |