Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes.
International audience Regulatory volume decrease (RVD) constitutes a fundamental process that turbot (Scophthalmus maximus) hepatocytes are able to perform when exposed to hypo-osmotic stress. RVD is an integrative mechanism that involves various elements of the cellular machinery. Among others, AT...
Published in: | Biochemistry and Cell Biology |
---|---|
Main Authors: | , , , , , |
Other Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2009
|
Subjects: | |
Online Access: | https://hal.univ-brest.fr/hal-00753921 https://doi.org/10.1139/o09-009 |
id |
ftunivbrest:oai:HAL:hal-00753921v1 |
---|---|
record_format |
openpolar |
spelling |
ftunivbrest:oai:HAL:hal-00753921v1 2024-01-07T09:46:36+01:00 Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes. Fouchs, Audrey Ollivier, Hélène Theron, Michael Roy, Stella Calvès, Patrick Pichavant-Rafini, Karine Optimisation des régulations physiologiques (ORPHY (EA 4324)) Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM) Université de Brest (UBO)-Université de Brest (UBO) 2009-06 https://hal.univ-brest.fr/hal-00753921 https://doi.org/10.1139/o09-009 en eng HAL CCSD NRC Research Press info:eu-repo/semantics/altIdentifier/doi/10.1139/o09-009 info:eu-repo/semantics/altIdentifier/pmid/19448743 hal-00753921 https://hal.univ-brest.fr/hal-00753921 doi:10.1139/o09-009 PUBMED: 19448743 ISSN: 0829-8211 EISSN: 1208-6002 Biochemistry and Cell Biology https://hal.univ-brest.fr/hal-00753921 Biochemistry and Cell Biology, 2009, 87 (3), pp.499-504. ⟨10.1139/o09-009⟩ MESH: Adenosine Triphosphate MESH: Animals MESH: Cell Size MESH: Electron Transport MESH: Exocytosis MESH: Flatfishes MESH: Hepatocytes MESH: Oxygen Consumption [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] info:eu-repo/semantics/article Journal articles 2009 ftunivbrest https://doi.org/10.1139/o09-009 2023-12-12T23:35:57Z International audience Regulatory volume decrease (RVD) constitutes a fundamental process that turbot (Scophthalmus maximus) hepatocytes are able to perform when exposed to hypo-osmotic stress. RVD is an integrative mechanism that involves various elements of the cellular machinery. Among others, ATP is an essential protagonist: released following hypo-osmotic shock, it acts as an auto/paracrine factor to trigger other signalling events. The origin of this ATP remains unclear and, to the best of our knowledge, no information exists about the role of mitochondrial respiration in RVD. Therefore, we propose to analyse the potential link between RVD and the respiratory chain, with a focus on ATP release and exocytosis. Using inhibitors of mitochondrial respiration, RVD was shown to be dependent on respiratory chain activity. However, we demonstrated an indirect role of mitochondrial respiration: ATP could be synthesized and then stored in intracellular vesicles until the moment cells release it to face hypo-osmotic swelling. However, the involvement of exocytosis in this process needs to be further investigated. Article in Journal/Newspaper Scophthalmus maximus Turbot Université de Bretagne Occidentale: HAL Biochemistry and Cell Biology 87 3 499 504 |
institution |
Open Polar |
collection |
Université de Bretagne Occidentale: HAL |
op_collection_id |
ftunivbrest |
language |
English |
topic |
MESH: Adenosine Triphosphate MESH: Animals MESH: Cell Size MESH: Electron Transport MESH: Exocytosis MESH: Flatfishes MESH: Hepatocytes MESH: Oxygen Consumption [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] |
spellingShingle |
MESH: Adenosine Triphosphate MESH: Animals MESH: Cell Size MESH: Electron Transport MESH: Exocytosis MESH: Flatfishes MESH: Hepatocytes MESH: Oxygen Consumption [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Fouchs, Audrey Ollivier, Hélène Theron, Michael Roy, Stella Calvès, Patrick Pichavant-Rafini, Karine Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes. |
topic_facet |
MESH: Adenosine Triphosphate MESH: Animals MESH: Cell Size MESH: Electron Transport MESH: Exocytosis MESH: Flatfishes MESH: Hepatocytes MESH: Oxygen Consumption [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] |
description |
International audience Regulatory volume decrease (RVD) constitutes a fundamental process that turbot (Scophthalmus maximus) hepatocytes are able to perform when exposed to hypo-osmotic stress. RVD is an integrative mechanism that involves various elements of the cellular machinery. Among others, ATP is an essential protagonist: released following hypo-osmotic shock, it acts as an auto/paracrine factor to trigger other signalling events. The origin of this ATP remains unclear and, to the best of our knowledge, no information exists about the role of mitochondrial respiration in RVD. Therefore, we propose to analyse the potential link between RVD and the respiratory chain, with a focus on ATP release and exocytosis. Using inhibitors of mitochondrial respiration, RVD was shown to be dependent on respiratory chain activity. However, we demonstrated an indirect role of mitochondrial respiration: ATP could be synthesized and then stored in intracellular vesicles until the moment cells release it to face hypo-osmotic swelling. However, the involvement of exocytosis in this process needs to be further investigated. |
author2 |
Optimisation des régulations physiologiques (ORPHY (EA 4324)) Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM) Université de Brest (UBO)-Université de Brest (UBO) |
format |
Article in Journal/Newspaper |
author |
Fouchs, Audrey Ollivier, Hélène Theron, Michael Roy, Stella Calvès, Patrick Pichavant-Rafini, Karine |
author_facet |
Fouchs, Audrey Ollivier, Hélène Theron, Michael Roy, Stella Calvès, Patrick Pichavant-Rafini, Karine |
author_sort |
Fouchs, Audrey |
title |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes. |
title_short |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes. |
title_full |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes. |
title_fullStr |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes. |
title_full_unstemmed |
Involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes. |
title_sort |
involvement of respiratory chain in the regulatory volume decrease process in turbot hepatocytes. |
publisher |
HAL CCSD |
publishDate |
2009 |
url |
https://hal.univ-brest.fr/hal-00753921 https://doi.org/10.1139/o09-009 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
ISSN: 0829-8211 EISSN: 1208-6002 Biochemistry and Cell Biology https://hal.univ-brest.fr/hal-00753921 Biochemistry and Cell Biology, 2009, 87 (3), pp.499-504. ⟨10.1139/o09-009⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1139/o09-009 info:eu-repo/semantics/altIdentifier/pmid/19448743 hal-00753921 https://hal.univ-brest.fr/hal-00753921 doi:10.1139/o09-009 PUBMED: 19448743 |
op_doi |
https://doi.org/10.1139/o09-009 |
container_title |
Biochemistry and Cell Biology |
container_volume |
87 |
container_issue |
3 |
container_start_page |
499 |
op_container_end_page |
504 |
_version_ |
1787428448508051456 |