Enzymatic systems involved in peri-receptor events of olfaction in mammalian: evolutionary perspectives
Keynote in conferencer 4 november. International audience The olfactory epithelium is continuously exposed to exogenous chemicals, including compounds bearing odor activity. Organisms have developed multiple mechanisms for the protection of this epithelium, among which anti-microbial proteins, enzym...
Main Author: | |
---|---|
Other Authors: | , , , |
Format: | Conference Object |
Language: | English |
Published: |
HAL CCSD
2021
|
Subjects: | |
Online Access: | https://hal.science/hal-03428705 |
id |
ftunivbourgogne:oai:HAL:hal-03428705v1 |
---|---|
record_format |
openpolar |
spelling |
ftunivbourgogne:oai:HAL:hal-03428705v1 2023-10-09T21:52:09+02:00 Enzymatic systems involved in peri-receptor events of olfaction in mammalian: evolutionary perspectives Neiers, F. Centre des Sciences du Goût et de l'Alimentation Dijon (CSGA) Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Université Bourgogne Franche-Comté COMUE (UBFC) GDR03 Virtual meeting, France 2021-11-03 https://hal.science/hal-03428705 en eng HAL CCSD hal-03428705 https://hal.science/hal-03428705 CSiV 2021: Chemical Signals in Vertebrates https://hal.science/hal-03428705 CSiV 2021: Chemical Signals in Vertebrates, GDR03, Nov 2021, Virtual meeting, France https://www.gdr-o3.cnrs.fr/2021/01/01/conference-15th-international-conference-on-chemical-signals-in-vertebrates/ olfactory peri receptor events enzyme evolution [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology info:eu-repo/semantics/conferenceObject Conference papers 2021 ftunivbourgogne 2023-09-12T23:18:47Z Keynote in conferencer 4 november. International audience The olfactory epithelium is continuously exposed to exogenous chemicals, including compounds bearing odor activity. Organisms have developed multiple mechanisms for the protection of this epithelium, among which anti-microbial proteins, enzymes fighting the oxidative stress and xenobiotic metabolizing enzymes. Our approach consists in characterizing by immunohistochemistry and mass spectroscopy analysis the proteome of the nasal mucus in different mammals (currently including Harbour porpoise, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus). These analyses reveal core some enzyme families in the different species investigated, including glutathione transferases (GSTs). GSTs represent a large family of enzymes comprising numerous members that appear ubiquitous in terrestrial organisms. GSTs operate in catalyzing the conjugation of glutathione (present in the nasal mucus) with various compounds including odorants, leading to their elimination and thus playing a role in the termination of the olfactory stimulus. Our results support the function of GSTs in the peripheral olfactory process, in terms of modulation of odorant availability for the olfactory receptors. We will explore the expression and function of the GST enzymes in different species of mammals and their redundant functions in the olfactory system. These results on mammalian GSTs will be discussed in an evolutionary perspective in comparison with insect GSTs. Despite insects have evolved a distinct olfactory system from mammals, their GSTs have a similar role in olfaction. Conference Object Harbour porpoise Université de Bourgogne (UB): HAL |
institution |
Open Polar |
collection |
Université de Bourgogne (UB): HAL |
op_collection_id |
ftunivbourgogne |
language |
English |
topic |
olfactory peri receptor events enzyme evolution [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology |
spellingShingle |
olfactory peri receptor events enzyme evolution [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Neiers, F. Enzymatic systems involved in peri-receptor events of olfaction in mammalian: evolutionary perspectives |
topic_facet |
olfactory peri receptor events enzyme evolution [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology |
description |
Keynote in conferencer 4 november. International audience The olfactory epithelium is continuously exposed to exogenous chemicals, including compounds bearing odor activity. Organisms have developed multiple mechanisms for the protection of this epithelium, among which anti-microbial proteins, enzymes fighting the oxidative stress and xenobiotic metabolizing enzymes. Our approach consists in characterizing by immunohistochemistry and mass spectroscopy analysis the proteome of the nasal mucus in different mammals (currently including Harbour porpoise, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus). These analyses reveal core some enzyme families in the different species investigated, including glutathione transferases (GSTs). GSTs represent a large family of enzymes comprising numerous members that appear ubiquitous in terrestrial organisms. GSTs operate in catalyzing the conjugation of glutathione (present in the nasal mucus) with various compounds including odorants, leading to their elimination and thus playing a role in the termination of the olfactory stimulus. Our results support the function of GSTs in the peripheral olfactory process, in terms of modulation of odorant availability for the olfactory receptors. We will explore the expression and function of the GST enzymes in different species of mammals and their redundant functions in the olfactory system. These results on mammalian GSTs will be discussed in an evolutionary perspective in comparison with insect GSTs. Despite insects have evolved a distinct olfactory system from mammals, their GSTs have a similar role in olfaction. |
author2 |
Centre des Sciences du Goût et de l'Alimentation Dijon (CSGA) Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Université Bourgogne Franche-Comté COMUE (UBFC) GDR03 |
format |
Conference Object |
author |
Neiers, F. |
author_facet |
Neiers, F. |
author_sort |
Neiers, F. |
title |
Enzymatic systems involved in peri-receptor events of olfaction in mammalian: evolutionary perspectives |
title_short |
Enzymatic systems involved in peri-receptor events of olfaction in mammalian: evolutionary perspectives |
title_full |
Enzymatic systems involved in peri-receptor events of olfaction in mammalian: evolutionary perspectives |
title_fullStr |
Enzymatic systems involved in peri-receptor events of olfaction in mammalian: evolutionary perspectives |
title_full_unstemmed |
Enzymatic systems involved in peri-receptor events of olfaction in mammalian: evolutionary perspectives |
title_sort |
enzymatic systems involved in peri-receptor events of olfaction in mammalian: evolutionary perspectives |
publisher |
HAL CCSD |
publishDate |
2021 |
url |
https://hal.science/hal-03428705 |
op_coverage |
Virtual meeting, France |
genre |
Harbour porpoise |
genre_facet |
Harbour porpoise |
op_source |
CSiV 2021: Chemical Signals in Vertebrates https://hal.science/hal-03428705 CSiV 2021: Chemical Signals in Vertebrates, GDR03, Nov 2021, Virtual meeting, France https://www.gdr-o3.cnrs.fr/2021/01/01/conference-15th-international-conference-on-chemical-signals-in-vertebrates/ |
op_relation |
hal-03428705 https://hal.science/hal-03428705 |
_version_ |
1779315297591754752 |