Free DNA, a reason for severe COVID-19 infection?
The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. Howev...
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Medical Hypotheses
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ftunivbogotajtl:oai:expeditiorepositorio.utadeo.edu.co:20.500.12010/12092 2023-05-15T13:33:03+02:00 Free DNA, a reason for severe COVID-19 infection? Liu, Bin 2020 3 páginas image/jepg image/png application/pdf https://hdl.handle.net/20.500.12010/12092 https://doi.org/10.1016/j.mehy.2020.109812 eng eng Medical Hypotheses 0306-9877 https://doi.org/10.1016/j.mehy.2020.109812 http://hdl.handle.net/20.500.12010/12092 info:eu-repo/semantics/embargoedAccess Acceso restringido reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano COVID-19 DNA Infection Síndrome respiratorio agudo grave SARS-CoV-2 Coronavirus Artículo info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_6501 2020 ftunivbogotajtl https://doi.org/20.500.12010/12092 https://doi.org/10.1016/j.mehy.2020.109812 2022-11-17T07:43:54Z The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. However, the etiology of severe COVID-19 has been largely unknown. Similar as SARS-CoV and MERS-CoV, SARS-CoV-2 is also thought derived from bat coronaviruses. However, it is not pathogenic for bat at all, because free DNA in cytoplasm or blood cannot bring up violent immune response in bat; but it can produce severe inflammations in human. I hypothesized that the damage induced by free DNA is a reason for severe COVID-19, which can explain many symptoms of this disease, such as cytokine storm, acute respiratory distress syndrome (ARDS) and muscus plug, acute injuries of heart, liver and kidney, and some special symptoms of COVID-19. My hypothesis will be helpful for better understand the etiology of severe COVID-19. Article in Journal/Newspaper Antarc* Antarctica Expeditio - Repositorio Institucional Universidad de Bogotá Jorge Tadeo Lozano (UTADEO) |
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Open Polar |
collection |
Expeditio - Repositorio Institucional Universidad de Bogotá Jorge Tadeo Lozano (UTADEO) |
op_collection_id |
ftunivbogotajtl |
language |
English |
topic |
COVID-19 DNA Infection Síndrome respiratorio agudo grave SARS-CoV-2 Coronavirus |
spellingShingle |
COVID-19 DNA Infection Síndrome respiratorio agudo grave SARS-CoV-2 Coronavirus Liu, Bin Free DNA, a reason for severe COVID-19 infection? |
topic_facet |
COVID-19 DNA Infection Síndrome respiratorio agudo grave SARS-CoV-2 Coronavirus |
description |
The fast-growing outbreak of 2019 novel coronaviruses (SARS-CoV-2) reached all continents except the Antarctica in merely three months. Severe SARS-CoV-2 infection (COVID-19) has a bad clinical outcome, and some reports emphasized the role of cytokine storm and dysfunctions of multiple organs. However, the etiology of severe COVID-19 has been largely unknown. Similar as SARS-CoV and MERS-CoV, SARS-CoV-2 is also thought derived from bat coronaviruses. However, it is not pathogenic for bat at all, because free DNA in cytoplasm or blood cannot bring up violent immune response in bat; but it can produce severe inflammations in human. I hypothesized that the damage induced by free DNA is a reason for severe COVID-19, which can explain many symptoms of this disease, such as cytokine storm, acute respiratory distress syndrome (ARDS) and muscus plug, acute injuries of heart, liver and kidney, and some special symptoms of COVID-19. My hypothesis will be helpful for better understand the etiology of severe COVID-19. |
format |
Article in Journal/Newspaper |
author |
Liu, Bin |
author_facet |
Liu, Bin |
author_sort |
Liu, Bin |
title |
Free DNA, a reason for severe COVID-19 infection? |
title_short |
Free DNA, a reason for severe COVID-19 infection? |
title_full |
Free DNA, a reason for severe COVID-19 infection? |
title_fullStr |
Free DNA, a reason for severe COVID-19 infection? |
title_full_unstemmed |
Free DNA, a reason for severe COVID-19 infection? |
title_sort |
free dna, a reason for severe covid-19 infection? |
publisher |
Medical Hypotheses |
publishDate |
2020 |
url |
https://hdl.handle.net/20.500.12010/12092 https://doi.org/10.1016/j.mehy.2020.109812 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
reponame:Expeditio Repositorio Institucional UJTL instname:Universidad de Bogotá Jorge Tadeo Lozano |
op_relation |
0306-9877 https://doi.org/10.1016/j.mehy.2020.109812 http://hdl.handle.net/20.500.12010/12092 |
op_rights |
info:eu-repo/semantics/embargoedAccess Acceso restringido |
op_doi |
https://doi.org/20.500.12010/12092 https://doi.org/10.1016/j.mehy.2020.109812 |
_version_ |
1766038066926977024 |